Caiazzi Jillian相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

An Aptamer-Based EXACT Anticoagulant as a Sustainable, Animal-Free Alternative to Unfractionated Heparin

一种基于适配体的EXACT抗凝剂，可作为普通肝素的可持续、无动物成分替代品。

期刊:Advanced Science

影响因子:14.1

doi:10.1002/advs.202509867

Yu, Haixiang; Pitoc, George; Zhang, Manqi; Clancy, Jeffrey; Frederiksen, James; Yan, Amy; Francis, Samuel; Sullenger, Rebecca; Rempel, Rachel; Gammell, Susannah; Caiazzi, Jillian; Sullenger, Bruce A

发表日期：2026

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An siRNA targeting S6k1 identifies photoreceptor phospholipid metabolism as a contributor to lipid buildup in age-related macular degeneration.

针对 S6k1 的 siRNA 发现光感受器磷脂代谢是导致年龄相关性黄斑变性中脂质积累的因素之一。

期刊:Molecular Therapy-Nucleic Acids

影响因子:6.1

doi:10.1016/j.omtn.2026.102878

Cheng Shun-Yun, Giguere Delaney, Kim San, Seddon Johanna M, Caiazzi Jillian, Gross Katherine, McHugh Nicholas, Echeverria Dimas, Alterman Julia F, Gray-Edwards Heather, Benatti Hector Ribeiro, Renner Lauren, Woolard Hannah, Stoddard Jonathan, McGill Trevor J, Neuringer Martha, Brush Richard S, Agbaga Martin-Paul, Khvorova Anastasia, Punzo Claudio

发表日期：2026

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Organyl 5'-Phosphates in siRNA Guide Strands: Structure-Function Relationships Governing Anchoring in Argonaute 2 and Metabolic Stability

siRNA引导链中的有机5'-磷酸酯：调控Argonaute 2锚定和代谢稳定性的结构-功能关系

doi:10.64898/2026.02.13.705631

Carrigan-Broda, Theodore; Gebert, Luca F R; Hildebrand, Samuel; Yamada, Nozomi; Luu, Eric; Caiazzi, Jillian; McHugh, Nicholas; Echeverria, Dimas; Wagh, Atish; Watts, Jonathan K; Khvorova, Anastasia; MacRae, Ian J; Yamada, Ken

发表日期：2026

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Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs

利用化学成分明确的亲脂性siRNA在心脏和肌肉中实现高效持久的基因调控

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkaf1374

Fakih, Hassan H; Lochmann, Clemens; Gagnon, Rosemary; Summers, Ashley; Caiazzi, Jillian; Buchwald, Julianna E; Tang, Qi; Maru, Bruktawit; Hildebrand, Samuel R; Abideen, Mohammad Zain U I; Furgal, Raymond C; Gross, Katherine Y; Yang, Yeon-Suk; Cooper, David; Monopoli, Kathryn R; Echeverria, Dimas; Shim, Jae-Hyuck; Yamada, Ken; Alterman, Julia F; Khvorova, Anastasia

发表日期：2025

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Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model

单次注射靶向 MECP2 的治疗性二价 siRNA 可使 MECP2 重复小鼠模型免于死亡一年。

doi:10.1101/2025.03.26.645328

Hariharan, Vignesh N; Summers, Ashley; Clipperton-Allen, Amy E; Caiazzi, Jillian; Hildebrand, Samuel R; O'Reilly, Daniel; Tang, Qi; Kennedy, Zachary; Echeverria, Dimas; McHugh, Nicholas; Cooper, David; Souza, Jacqueline; Ferguson, Chantal; Bogdanik, Laurent; Coenraads, Monica; Khvorova, Anastasia

发表日期：2025

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Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA

磷脂酰胆碱头部基团的化学性质会改变脂质偶联siRNA在肝外的积累。

期刊:Molecular Therapy-Nucleic Acids

影响因子:6.1

doi:10.1016/j.omtn.2024.102230

Hariharan, Vignesh N; Nakamura, Takahiro; Shin, Minwook; Tang, Qi; Sontakke, Vyankat; Caiazzi, Jillian; Hildebrand, Samuel; Khvorova, Anastasia; Yamada, Ken

发表日期：2024

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Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles.

将二十二碳酸与 siRNA 结合，可实现功能性且安全的递送至骨骼肌和心肌

期刊:Molecular Therapy

影响因子:12

doi:10.1016/j.ymthe.2020.12.023

Biscans Annabelle, Caiazzi Jillian, McHugh Nicholas, Hariharan Vignesh, Muhuri Manish, Khvorova Anastasia

发表日期：2021

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Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep

利用治疗性siRNA进行的给药途径比较研究表明，多塞特绵羊体内存在广泛的基因调控。

期刊:JCI Insight

影响因子:6.1

doi:10.1172/jci.insight.152203

Ferguson, Chantal M; Godinho, Bruno Mdc; Alterman, Julia F; Coles, Andrew H; Hassler, Matthew; Echeverria, Dimas; Gilbert, James W; Knox, Emily G; Caiazzi, Jillian; Haraszti, Reka A; King, Robert M; Taghian, Toloo; Puri, Ajit; Moser, Richard P; Gounis, Matthew J; Aronin, Neil; Gray-Edwards, Heather; Khvorova, Anastasia

发表日期：2021

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The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy.

疏水修饰的siRNA的化学结构和硫代磷酸酯含量会影响肝外分布和疗效

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkaa595

Biscans Annabelle, Caiazzi Jillian, Davis Sarah, McHugh Nicholas, Sousa Jacquelyn, Khvorova Anastasia

发表日期：2020

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