Caldecott Keith W相关文献与解析，生知库

Semenova, Svetlana A; Nammi, Deepthi; Garrett, Grace B; Margolin, Gennady; Sinclair, Jennifer L; Maroofian, Reza; Caldecott, Keith W; Burgess, Harold A

神经科学

发表日期：2025

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Deazaflavin Inhibitors of TDP2 with Cellular Activity Can Affect Etoposide Influx and/or Efflux

具有细胞活性的TDP2去氮黄素抑制剂可影响依托泊苷的流入和/或流出

期刊:ACS Chemical Biology

影响因子:3.8

doi:10.1021/acschembio.9b00144

Komulainen, Emilia; Pennicott, Lewis; Le Grand, Darren; Caldecott, Keith W

细胞生物学

发表日期：2019

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Homozygous pathogenic variant in BRAT1 associated with nonprogressive cerebellar ataxia

BRAT1基因纯合致病变异与非进行性小脑共济失调相关

期刊:Neurology-Genetics

影响因子:3.7

doi:10.1212/NXG.0000000000000359

Mahjoub, Areej; Cihlarova, Zuzana; Tétreault, Martine; MacNeil, Lauren; Sondheimer, Neal; Caldecott, Keith W; Hanzlikova, Hana; Yoon, Grace

神经科学

发表日期：2019

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Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin.

PARP1 和 PARP2 在将内源性 XRCC1 和 PNKP 募集到氧化染色质中的作用重叠

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkw1246

Hanzlikova Hana, Gittens William, Krejcikova Katerina, Zeng Zhihong, Caldecott Keith W

The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair

支架蛋白XRCC1中的Rev1相互作用区（RIR）基序在DNA单链断裂修复过程中介导与多核苷酸激酶/磷酸酶（PNKP）的低亲和力相互作用。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1074/jbc.M117.806638

Breslin, Claire; Mani, Rajam S; Fanta, Mesfin; Hoch, Nicolas; Weinfeld, Michael; Caldecott, Keith W

Identification and Functional Characterizations of N-Terminal α-N-Methylation and Phosphorylation of Serine 461 in Human Poly(ADP-ribose) Polymerase 3

人聚（ADP-核糖）聚合酶3中N端α-N-甲基化和丝氨酸461磷酸化的鉴定和功能表征

期刊:Journal of Proteome Research

影响因子:3.6

doi:10.1021/acs.jproteome.5b00126

Dai, Xiaoxia; Rulten, Stuart L; You, Changjun; Caldecott, Keith W; Wang, Yinsheng

3rd International Genome Dynamics in Neuroscience Conference: "DNA repair and neurological disease"

第三届神经科学基因组动力学国际会议：“DNA修复与神经系统疾病”

期刊:Mechanisms of Ageing and Development

影响因子:5.1

doi:10.1016/j.mad.2011.07.006

Caldecott, Keith W; Bohr, Vilhelm A; McKinnon, Peter J

Neuroscience

发表日期：2011

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TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage

TDP2/TTRAP是脊椎动物细胞中主要的5'-酪氨酰DNA磷酸二酯酶，对细胞抵抗拓扑异构酶II诱导的DNA损伤至关重要。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1074/jbc.M110.181016

Zeng, Zhihong; Cortés-Ledesma, Felipe; El Khamisy, Sherif F; Caldecott, Keith W

Mutations in PNKP cause microcephaly, seizures and defects in DNA repair

PNKP基因突变会导致小头畸形、癫痫和DNA修复缺陷。

期刊:Nature Genetics

影响因子:29

doi:10.1038/ng.526

Shen, Jun; Gilmore, Edward C; Marshall, Christine A; Haddadin, Mary; Reynolds, John J; Eyaid, Wafaa; Bodell, Adria; Barry, Brenda; Gleason, Danielle; Allen, Kathryn; Ganesh, Vijay S; Chang, Bernard S; Grix, Arthur; Hill, R Sean; Topcu, Meral; Caldecott, Keith W; Barkovich, A James; Walsh, Christopher A

FEN1 is critical for rapid single-strand break repair in G1 phase.

FEN1 在 G1 期快速修复单链断裂中起着至关重要的作用

Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish

Parp1基因缺失可挽救xrcc1突变斑马鱼的小脑萎缩。

Deazaflavin Inhibitors of TDP2 with Cellular Activity Can Affect Etoposide Influx and/or Efflux

具有细胞活性的TDP2去氮黄素抑制剂可影响依托泊苷的流入和/或流出

Homozygous pathogenic variant in BRAT1 associated with nonprogressive cerebellar ataxia

BRAT1基因纯合致病变异与非进行性小脑共济失调相关

Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin.

PARP1 和 PARP2 在将内源性 XRCC1 和 PNKP 募集到氧化染色质中的作用重叠

The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair

支架蛋白XRCC1中的Rev1相互作用区（RIR）基序在DNA单链断裂修复过程中介导与多核苷酸激酶/磷酸酶（PNKP）的低亲和力相互作用。

Identification and Functional Characterizations of N-Terminal α-N-Methylation and Phosphorylation of Serine 461 in Human Poly(ADP-ribose) Polymerase 3

人聚（ADP-核糖）聚合酶3中N端α-N-甲基化和丝氨酸461磷酸化的鉴定和功能表征

3rd International Genome Dynamics in Neuroscience Conference: "DNA repair and neurological disease"

第三届神经科学基因组动力学国际会议：“DNA修复与神经系统疾病”

TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage

TDP2/TTRAP是脊椎动物细胞中主要的5'-酪氨酰DNA磷酸二酯酶，对细胞抵抗拓扑异构酶II诱导的DNA损伤至关重要。

Mutations in PNKP cause microcephaly, seizures and defects in DNA repair

PNKP基因突变会导致小头畸形、癫痫和DNA修复缺陷。