日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13

CDK12 缺失驱动前列腺癌进展、转录-复制冲突以及与旁系同源基因 CDK13 的合成致死性

Jean Ching-Yi Tien ,Jie Luo ,Yu Chang ,Yuping Zhang ,Yunhui Cheng ,Xiaoju Wang ,Jianzhang Yang ,Rahul Mannan ,Somnath Mahapatra ,Palak Shah ,Xiao-Ming Wang ,Abigail J Todd ,Sanjana Eyunni ,Caleb Cheng ,Ryan J Rebernick ,Lanbo Xiao ,Yi Bao ,James Neiswender ,Rachel Brough ,Stephen J Pettitt ,Xuhong Cao ,Stephanie J Miner ,Licheng Zhou ,Yi-Mi Wu ,Estefania Labanca ,Yuzhuo Wang ,Abhijit Parolia ,Marcin Cieslik ,Dan R Robinson ,Zhen Wang ,Felix Y Feng ,Jonathan Chou ,Christopher J Lord ,Ke Ding ,Arul M Chinnaiyan

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

以 PIKfyve 驱动的脂质稳态作为胰腺癌代谢脆弱性的目标

Caleb Cheng, Jing Hu, Rahul Mannan, Rupam Bhattacharyya, Nicholas J Rossiter, Brian Magnuson, Jasmine P Wisniewski, Yang Zheng, Lanbo Xiao, Chungen Li, Dominik Awad, Tongchen He, Yi Bao, Yuping Zhang, Xuhong Cao, Zhen Wang, Rohit Mehra, Pietro Morlacchi, Vaibhav Sahai, Marina Pasca di Magliano, Yatr

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

CDK12 缺失会促进前列腺癌的发展,同时暴露出基于旁系同源物的合成致死性的弱点

Jean Ching-Yi Tien, Yu Chang, Yuping Zhang, Jonathan Chou, Yunhui Cheng, Xiaoju Wang, Jianzhang Yang, Rahul Mannan, Palak Shah, Xiao-Ming Wang, Abigail J Todd, Sanjana Eyunni, Caleb Cheng, Ryan J Rebernick, Lanbo Xiao, Yi Bao, James Neiswender, Rachel Brough, Stephen J Pettitt, Xuhong Cao, Stephanie

Discovery of a First-in-Class Degrader for the Lipid Kinase PIKfyve

发现首创的脂质激酶 PIKfyve 降解剂

Chungen Li, Yuanyuan Qiao, Xia Jiang, Lianchao Liu, Yang Zheng, Yudi Qiu, Caleb Cheng, Fengtao Zhou, Yang Zhou, Weixue Huang, Xiaomei Ren, Yuzhuo Wang, Zhen Wang, Arul M Chinnaiyan, Ke Ding

Targeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy

靶向脂质激酶 PIKfyve 可上调 MHC I 类的表面表达,从而增强癌症免疫疗法

Yi Bao, Yuanyuan Qiao, Jae Eun Choi, Yuping Zhang, Rahul Mannan, Caleb Cheng, Tongchen He, Yang Zheng, Jiali Yu, Mahnoor Gondal, Gabriel Cruz, Sara Grove, Xuhong Cao, Fengyun Su, Rui Wang, Yu Chang, Ilona Kryczek, Marcin Cieslik, Michael D Green, Weiping Zou, Arul M Chinnaiyan

Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions

出生后敲除Spns2基因可预防神经炎症,且不损害血管功能。

Hasan, Zafrul; Nguyen, Toan Q; Lam, Brenda Wan Shing; Wong, Jovi Hui Xin; Wong, Caleb Cheng Yi; Tan, Clarissa Kai Hui; Yu, Jiabo; Thiam, Chung Hwee; Zhang, Yongliang; Angeli, Veronique; Nguyen, Long N