日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease

通过单次核转录组学表征阿尔茨海默病中血管生成受损和血脑屏障功能障碍的机制

Stergios Tsartsalis # ,Hannah Sleven # ,Nurun Fancy # ,Frank Wessely ,Amy M Smith ,Nanet Willumsen ,To Ka Dorcas Cheung ,Michal J Rokicki ,Vicky Chau ,Eseoghene Ifie ,Combiz Khozoie ,Olaf Ansorge ,Xin Yang ,Marion H Jenkyns ,Karen Davey ,Aisling McGarry ,Robert C J Muirhead ,Stephanie Debette ,Johanna S Jackson ,Axel Montagne ,David R Owen ,J Scott Miners ,Seth Love ,Caleb Webber ,M Zameel Cader ,Paul M Matthews

Single-Cell Transcriptomics and In Vitro Lineage Tracing Reveals Differential Susceptibility of Human iPSC-Derived Midbrain Dopaminergic Neurons in a Cellular Model of Parkinson's Disease

单细胞转录组学和体外谱系追踪揭示帕金森病细胞模型中人类 iPSC 衍生的中脑多巴胺能神经元的差异易感性

Lucia F Cardo, Jimena Monzón-Sandoval, Zongze Li, Caleb Webber, Meng Li

Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer's disease mouse models

脂多糖明显改变人类小胶质细胞转录组,使其类似于阿尔茨海默病小鼠模型中的小胶质细胞

Jimena Monzón-Sandoval, Elena Burlacu, Devika Agarwal, Adam E Handel, Liting Wei, John Davis, Sally A Cowley, M Zameel Cader, Caleb Webber

Combining multiomics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy

结合多组学和药物扰动谱来确定脊髓性肌萎缩症的肌肉特异性治疗方法

Katharina E Meijboom, Viola Volpato, Jimena Monzón-Sandoval, Joseph M Hoolachan, Suzan M Hammond, Frank Abendroth, Olivier G de Jong, Gareth Hazell, Nina Ahlskog, Matthew Ja Wood, Caleb Webber, Melissa Bowerman

Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories

转录因子的靶向单细胞 RNA 测序增强了细胞类型和轨迹的识别

Alexandra Pokhilko, Adam E Handel, Fabiola Curion, Viola Volpato, Emma S Whiteley, Sunniva Bøstrand, Sarah E Newey, Colin J Akerman, Caleb Webber, Michael B Clark, Rory Bowden, M Zameel Cader

Human-Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons

中脑腹侧和背部多巴胺神经元的人类特异性转录组

Jimena Monzón-Sandoval, Ilaria Poggiolini, Tobias Ilmer, Richard Wade-Martins, Caleb Webber, Laura Parkkinen

TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages

TREM2 阿尔茨海默病变体 R47H 会导致与基因敲除类似的转录失调,但在人类 iPSC 衍生的巨噬细胞中仅表现出轻微的功能表型。

Hazel Hall-Roberts ,Devika Agarwal ,Juliane Obst ,Thomas B Smith ,Jimena Monzón-Sandoval ,Elena Di Daniel ,Caleb Webber ,William S James ,Emma Mead ,John B Davis ,Sally A Cowley

Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson's disease

外周组织的深度表型分析有助于散发性帕金森病的机械疾病分层

Phillippa J Carling, Heather Mortiboys, Claire Green, Simeon Mihaylov, Cynthia Sandor, Aurelie Schwartzentruber, Rosie Taylor, Wenbin Wei, Chris Hastings, Siew Wong, Christine Lo, Samuel Evetts, Hannah Clemmens, Matthew Wyles, Sam Willcox, Thomas Payne, Rachel Hughes, Laura Ferraiuolo, Caleb Webber,

Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons

人类 iPSC 衍生的皮质星形胶质细胞对 iPSC 衍生的皮质神经元的促成熟作用

Anne Hedegaard, Jimena Monzón-Sandoval, Sarah E Newey, Emma S Whiteley, Caleb Webber, Colin J Akerman

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes

对iPSC-多巴胺神经元进行单细胞测序,重建疾病进展并鉴定出HDAC4是帕金森细胞表型的调节因子

Charmaine Lang ,Kieran R Campbell ,Brent J Ryan ,Phillippa Carling ,Moustafa Attar ,Jane Vowles ,Olga V Perestenko ,Rory Bowden ,Fahd Baig ,Meike Kasten ,Michele T Hu ,Sally A Cowley ,Caleb Webber ,Richard Wade-Martins