Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life.
急性靶向 N 端 tau 蛋白在 Tg2576 APP/Aβ 小鼠模型中具有持久的有益效果，可减少晚年的认知障碍、脑 Aβ 淀粉样变性、突触重塑和小胶质细胞增生
期刊:Acta Neuropathologica Communications
影响因子:5.7
doi:10.1186/s40478-025-02022-y
Latina Valentina, De Introna Margherita, Malerba Francesca, Florio Rita, Balzamino Bijorn Omar, Di Natale Giuseppe, Sciacca Michele Francesco Maria, Pappalardo Giuseppe, Micera Alessandra, Pignataro Annabella, Calissano Pietro, Amadoro Giuseppina
