Calum Sutherland相关文献与解析，生知库 | 链接生命科学的每一步

Andreas Holmqvist #，Nur Mehpare Kocaturk #，Christina Duncan，Jennifer Riley，Steven Baginski，Graham Marsh，Joel Cresser-Brown，Hannah Maple，Kristiina Juvonen，Gajanan Sathe，Nicola Morrice，Calum Sutherland，Kevin D Read，William Farnaby

神经科学

GSK3

发表日期：2025

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Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells

抑制糖原合酶激酶 3 可增强胰腺 β 细胞中 NRF2 蛋白的稳定性、核定位和靶基因转录

期刊:Redox Biology

影响因子:10.7

doi:10.1016/j.redox.2024.103117

Chinmai Patibandla, Lidy van Aalten, Albena T Dinkova-Kostova, Tadashi Honda, Antonio Cuadrado, Raquel Fernández-Ginés, Alison D McNeilly, John D Hayes, James Cantley, Calum Sutherland

Elraglusib Induces Cytotoxicity via Direct Microtubule Destabilization Independently of GSK3 Inhibition

Elraglusib 通过直接微管不稳定诱导细胞毒性，而不依赖于 GSK3 抑制

期刊:Cancer Research Communications

影响因子:2

doi:10.1158/2767-9764.CRC-24-0408

Josh T Coats, Shuyu Li, Tomoyuki U Tanaka, Sudhir Tauro, Calum Sutherland, Adrian T Saurin

Elraglusib (formerly 9-ING-41) possesses potent anti-lymphoma properties which cannot be attributed to GSK3 inhibition

Elraglusib（以前称为 9-ING-41）具有强大的抗淋巴瘤特性，这不能归因于 GSK3 抑制

期刊:Cell Communication and Signaling

影响因子:8.2

doi:10.1186/s12964-023-01147-8

Josh T Coats, Sudhir Tauro, Calum Sutherland

Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes

Syntaxin-16 的 N 端磷酸化控制与脂肪细胞中 mVps45 和 GLUT4 运输的相互作用

期刊:PeerJ

影响因子:2.3

doi:10.7717/peerj.15630

Shaun K Bremner, Rebecca Berends, Alexandra Kaupisch, Jennifer Roccisana, Calum Sutherland, Nia J Bryant, Gwyn W Gould

Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes

通过基因编辑在培养的脂肪细胞中鉴定出 Syntaxin16 的多效性作用

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.6

doi:10.3389/fcell.2022.1033501

Shaun K Bremner, Woroud S Al Shammari, Roderick S Milligan, Brian D Hudson, Calum Sutherland, Nia J Bryant, Gwyn W Gould

The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection

转录因子 NPAT 与二甲双胍血糖反应的遗传关联涉及燃料选择的调节

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0253533

Changwei Chen, Jennifer R Gallagher, Jamie Tarlton, Lidy van Aalten, Susan E Bray, Michael L J Ashford, Rory J McCrimmon, Ewan R Pearson, Alison D McNeilly, Calum Sutherland

信号转导

发表日期：2021

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Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

CRMP2 O-GlcNAc 糖基化缺失导致小鼠新物体识别能力下降

期刊:Open Biology

影响因子:4.5

doi:10.1098/rsob.190192

Villo Muha, Ritchie Williamson, Rachel Hills, Alison D McNeilly, Thomas G McWilliams, Jana Alonso, Marianne Schimpl, Aneika C Leney, Albert J R Heck, Calum Sutherland, Kevin D Read, Rory J McCrimmon, Simon P Brooks, Daan M F van Aalten

信号转导

发表日期：2019

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Recruitment, Retainment, and Biomarkers of Response; A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment

招募、保留和反应生物标志物；对轻度认知障碍患者进行锂的试点试验

期刊:Frontiers in Molecular Neuroscience

影响因子:3.5

doi:10.3389/fnmol.2019.00163

Ashleigh Duthie, Lidy van Aalten, Cara MacDonald, Alison McNeilly, Jennifer Gallagher, John Geddes, Simon Lovestone, Calum Sutherland

Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3)

Rab-GTPase 结合效应蛋白 2 (RABEP2) 是糖原合酶激酶 3 (GSK3) 的底物

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-017-17087-6

Lisa Logie, Lidy Van Aalten, Axel Knebel, Thomas Force, C James Hastie, Hilary MacLauchlan, David G Campbell, Robert Gourlay, Alan Prescott, Jane Davidson, Will Fuller, Calum Sutherland

信号转导

发表日期：2017

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Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening

利用正交反应连接子筛选发现一种具有中枢神经系统活性的GSK3降解剂

Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells

抑制糖原合酶激酶 3 可增强胰腺 β 细胞中 NRF2 蛋白的稳定性、核定位和靶基因转录

Elraglusib Induces Cytotoxicity via Direct Microtubule Destabilization Independently of GSK3 Inhibition

Elraglusib 通过直接微管不稳定诱导细胞毒性，而不依赖于 GSK3 抑制

Elraglusib (formerly 9-ING-41) possesses potent anti-lymphoma properties which cannot be attributed to GSK3 inhibition

Elraglusib（以前称为 9-ING-41）具有强大的抗淋巴瘤特性，这不能归因于 GSK3 抑制

Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes

Syntaxin-16 的 N 端磷酸化控制与脂肪细胞中 mVps45 和 GLUT4 运输的相互作用

Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes

通过基因编辑在培养的脂肪细胞中鉴定出 Syntaxin16 的多效性作用

The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection

转录因子 NPAT 与二甲双胍血糖反应的遗传关联涉及燃料选择的调节

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

CRMP2 O-GlcNAc 糖基化缺失导致小鼠新物体识别能力下降

Recruitment, Retainment, and Biomarkers of Response; A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment

招募、保留和反应生物标志物；对轻度认知障碍患者进行锂的试点试验

Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3)

Rab-GTPase 结合效应蛋白 2 (RABEP2) 是糖原合酶激酶 3 (GSK3) 的底物