日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Upregulation of a CFTR mRNA isoform has therapeutic potential for the treatment of 3' CFTR PTC variants

CFTR mRNA亚型的上调具有治疗3' CFTR PTC变异体的治疗潜力。

Allaire, Normand E; Armstrong, Matthew S; Yoon, Jae Seok; Walker, Mercy C; Bhatt, Priyanka; Harrington, Jan M; Cheng, Yi; Wong, Eric I; Mahoney, John E; Valley, Hillary C; Macadino, Caitlin M; Bihler, Hermann J; Sivachenko, Andrey Y; Cotton, Calvin U; Carulli, John P; Mense, Martin

Early developmental phenotypes in the cystic fibrosis sheep model

囊性纤维化绵羊模型中的早期发育表型

Van Wettere, Arnaud J; Leir, Shih-Hsing; Cotton, Calvin U; Regouski, Misha; Viotti Perisse, Iuri; Kerschner, Jenny L; Paranjapye, Alekh; Fan, Zhiqiang; Liu, Ying; Schacht, Makayla; White, Kenneth L; Polejaeva, Irina A; Harris, Ann

Synergy between Readthrough and Nonsense Mediated Decay Inhibition in a Murine Model of Cystic Fibrosis Nonsense Mutations

囊性纤维化无义突变小鼠模型中通读和无义介导衰变抑制之间的协同作用

Daniel R McHugh, Calvin U Cotton, Craig A Hodges

Evaluation of both exonic and intronic variants for effects on RNA splicing allows for accurate assessment of the effectiveness of precision therapies

评估外显子和内含子变异对 RNA 剪接的影响,可以准确评估精准治疗的有效性

Anya T Joynt, Taylor A Evans, Matthew J Pellicore, Emily F Davis-Marcisak, Melis A Aksit, Alice C Eastman, Shivani U Patel, Kathleen C Paul, Derek L Osorio, Alyssa D Bowling, Calvin U Cotton, Karen S Raraigh, Natalie E West, Christian A Merlo, Garry R Cutting, Neeraj Sharma

CFTR modulator theratyping: Current status, gaps and future directions

CFTR调节因子治疗分型:现状、差距和未来方向

Clancy, John Paul; Cotton, Calvin U; Donaldson, Scott H; Solomon, George M; VanDevanter, Donald R; Boyle, Michael P; Gentzsch, Martina; Nick, Jerry A; Illek, Beate; Wallenburg, John C; Sorscher, Eric J; Amaral, Margarida D; Beekman, Jeffrey M; Naren, Anjaparavanda P; Bridges, Robert J; Thomas, Philip J; Cutting, Garry; Rowe, Steven; Durmowicz, Anthony G; Mense, Martin; Boeck, Kris D; Skach, William; Penland, Christopher; Joseloff, Elizabeth; Bihler, Hermann; Mahoney, John; Borowitz, Drucy; Tuggle, Katherine L

Electrochemical measurement of membrane cholesterol correlates with CFTR function and is HDAC6-dependent

膜胆固醇的电化学测量与CFTR功能相关,并且依赖于HDAC6。

Lu, Binyu; Li, Li; Schneider, Molly; Hodges, Craig A; Cotton, Calvin U; Burgess, James D; Kelley, Thomas J

A BAC Transgene Expressing Human CFTR under Control of Its Regulatory Elements Rescues Cftr Knockout Mice

在其调节元件的控制下表达人类 CFTR 的 BAC 转基因挽救了 Cftr 基因敲除小鼠

Lara R Gawenis, Craig A Hodges, Daniel R McHugh, Dana M Valerio, Alexander Miron, Calvin U Cotton, Jinghua Liu, Nancy M Walker, Ashlee M Strubberg, Austin E Gillen, Michael J Mutolo, George Kotzamanis, Jürgen Bosch, Ann Harris, Mitchell L Drumm, Lane L Clarke

Acetyl-CoA carboxylase inhibition regulates microtubule dynamics and intracellular transport in cystic fibrosis epithelial cells

乙酰辅酶 A 羧化酶抑制调节囊性纤维化上皮细胞中的微管动力学和细胞内运输

Sharon M Rymut, Binyu Lu, Aura Perez, Deborah A Corey, Kata Lamb, Calvin U Cotton, Thomas J Kelley

A sheep model of cystic fibrosis generated by CRISPR/Cas9 disruption of the CFTR gene

利用 CRISPR/Cas9 技术破坏 CFTR 基因构建的囊性纤维化绵羊模型

Fan, Zhiqiang; Perisse, Iuri Viotti; Cotton, Calvin U; Regouski, Misha; Meng, Qinggang; Domb, Chaim; Van Wettere, Arnaud J; Wang, Zhongde; Harris, Ann; White, Kenneth L; Polejaeva, Irina A

Molecular characterization of gene regulatory networks in primary human tracheal and bronchial epithelial cells

人类原代气管和支气管上皮细胞基因调控网络的分子表征

Austin E Gillen, Rui Yang, Calvin U Cotton, Aura Perez, Scott H Randell, Shih-Hsing Leir, Ann Harris