SOS1 inhibitor BI-3406 shows in vivo antitumor activity akin to genetic ablation and synergizes with a KRAS(G12D) inhibitor in KRAS LUAD.
SOS1 抑制剂 BI-3406 在体内显示出类似于基因消融的抗肿瘤活性，并且与 KRAS(G12D) 抑制剂在 KRAS LUAD 中具有协同作用
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2422943122
Baltanás Fernando C, Kramer-Drauberg Maximilian, GarcÃa-Navas Rósula, Patrucco Enrico, Petrini Ettore, Arnhof Heribert, Olarte-San Juan Andrea, RodrÃguez-Ramos Pablo, Borrajo Javier, Calzada Nuria, Castellano Esther, Mair Barbara, Kostyrko Kaja, Hofmann Marco H, Ambrogio Chiara, Santos Eugenio
