日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GTP release-selective agonists prolong opioid analgesic efficacy

GTP释放选择性激动剂可延长阿片类镇痛药的疗效。

Stahl, Edward L; Swanson, Matthew A; Dang, Vuong Q; Cameron, Michael D; Kennedy, Nicole M; Bannister, Thomas D; Bohn, Laura M

A cryptic pocket in CB1 drives peripheral and functional selectivity

CB1 中的一个隐蔽口袋驱动外周和功能选择性

Rangari, Vipin Ashok; O'Brien, Evan S; Powers, Alexander S; Slivicki, Richard A; Bertels, Zachariah; Appourchaux, Kevin; Aydin, Deniz; Ramos-Gonzalez, Nokomis; Mwirigi, Juliet; Lin, Li; Mangutov, Elizaveta; Sobecks, Briana L; Awad-Agbaria, Yaseen; Uphade, Manoj B; Aguilar, Jhoan; Peddada, Teja Nikhil; Shiimura, Yuki; Huang, Xi-Ping; Folarin-Hines, Jakayla; Payne, Maria; Kalathil, Anirudh; Varga, Balazs R; Kobilka, Brian K; Pradhan, Amynah A; Cameron, Michael D; Kumar, Kaavya Krishna; Dror, Ron O; Gereau, Robert W 4th; Majumdar, Susruta

Development of clinically viable non-muscle myosin II small molecule inhibitors.

开发具有临床应用价值的非肌肉肌球蛋白 II 小分子抑制剂

Radnai Laszlo, Young Erica J, Kikuti Carlos, Toth Katalin, Zhou Minghai, Hafenbreidel Madalyn, Stremel Rebecca F, Lin Li, Pasetto Paolo, Jin Xiaomin, Patel Aagam, Conlon Michael, Briggs Sherri B, Heidsieck Leïla, Sweeney H Lee, Sellers James, Krieger-Burke Teresa, Martin William H, Sisco Jay, Young Steven, Pearson Paul, Rumbaugh Gavin, Araldi Gian Luca, Duddy Steven K, Cameron Michael D, Surman Matthew, Houdusse Anne, Griffin Patrick R, Kamenecka Theodore M, Miller Courtney A

Structural determinants of non-covalent PPARγ inverse agonism and their therapeutic implications.

非共价 PPARγ 反向激动作用的结构决定因素及其治疗意义。

Kuo Kuang-Ting, Bdiri Bilel, He Yuanjun, Garcia-Ordonez Ruben D, McDougal Daniel P, Ruiz Claudia, Chang Mi Ra, Cameron Michael D, Bruning John B, Kamenecka Theodore M, Griffin Patrick R

A triple-action PROTAC for wild-type p53 cancer therapy

用于野生型p53癌症治疗的三重作用PROTAC

Bird, Gregory H; Adhikary, Utsarga; Schmidt, Michael J; Godes, Marina; Tesar, Bethany; Camara, Christina M; Paulo, Joao A; Vidlak, Julia F; DeAngelo, Thomas M; Marquez, Marilyn; Gokhale, Prafulla; Li, Ruitong; Ho Sui, Shannan J; Cameron, Michael D; Gygi, Steven P; Walensky, Loren D

Linker Optimization Enhances the Potency of Ribonuclease-Targeting Chimeras in Cancer Models.

连接子优化增强了核糖核酸酶靶向嵌合体在癌症模型中的效力

Meyer Samantha M, Kovachka Sandra, Wang Tenghui, Cameron Michael D, Childs-Disney Jessica L, Disney Matthew D

Development of a Novel Compound Effective Against Juvenile, Adult, and Drug-Resistant Schistosoma Species

开发一种对幼年、成年和耐药血吸虫均有效的新型化合物

Alwan, Sevan N; Taylor, Alexander B; McHardy, Stanton F; Cameron, Michael D; LoVerde, Philip T

Zika virus-induced fetal demise is triggered by strain- and dose-specific RLR-driven activation of the interferon response in the decidua, placenta, and fetus in Ifnar1(-/-) mice

在Ifnar1(-/-)小鼠中,寨卡病毒引起的胎儿死亡是由病毒株和剂量特异性的RLR驱动的干扰素反应激活所触发的,该激活发生在蜕膜、胎盘和胎儿中。

Bohm, Ellie K; Castañeda, David; Lu, Qun; Cameron, Michael D; Aliota, Matthew T

Design of an Orally Bioavailable Small Molecule That Modulates the Microtubule-Associated Protein Tau's Pre-mRNA Splicing

设计一种口服生物利用度高的小分子,用于调节微管相关蛋白Tau的前体mRNA剪接

Zhang, Peiyuan; Taghavi, Amirhossein; Abe, Masahito; Aikawa, Haruo; Akahori, Yoshihiro; Chen, Jonathan L; Tong, Yuquan; Baisden, Jared T; Cameron, Michael D; Childs-Disney, Jessica L; Disney, Matthew D

Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice

三唑187是一种偏向性κ阿片受体激动剂,可在不引起镇静的情况下抑制瘙痒,并诱导小鼠产生类似抗焦虑的行为。

Volf, Allison; Brust, Tarsis F; Kobylski, Robin R; Czekner, Kerri M; Stahl, Edward L; Cameron, Michael D; Trojniak, Ashley E; Aubé, Jeffrey; Bohn, Laura M