日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues

异位肝脏GLP-1R激动作用可增强GLP-1类似物的减肥效果。

Douros, Jonathan D; Capozzi, Megan; Novikoff, Aaron; Mokrosinski, Jacek; DuBois, Barent; Stock, Joseph; Rohlfs, Rebecca; Anderson, Mikayla; Jedrzejcyk, Dominika J; Poulsen, Svend; Blenke, Erik Oude; Dago, Tomas; Huus, Kasper; Nørby, Peder L; Kobberup, Sune; Rivir, Marita; Sorrell, Joyce; Mowery, Stephanie A; Drucker, Daniel J; D'Alessio, David A; Campbell, Jonathan E; Müller, Timo D; Perez-Tilve, Diego; Finan, Brian; Knerr, Patrick J

Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication.

局部 GLP1 受体预内化引导胰岛 α 细胞与 β 细胞之间的通讯

Tong Jason C L, Frazer-Morris Charlotte, Shilleh Ali H, Viloria Katrina, de Bray Anne, Nair Adithya Muraleedaran, Johnson Paul R V, Spiers Rebecca, Kobiita Ahmad, Olaniru Oladapo E, Persaud Shanta J, Hauffe Robert, Kleinridders André, Schultz Carsten, Bruce Verchere C, Cui Canqi, Campbell Jonathan E, Cyranka Malgorzata, Epanchintsev Alexey, Ämmälä Carina, Broichhagen Johannes, Hodson David J

β Cell Gαs signaling is critical for physiological and pharmacological enhancement of insulin secretion

β细胞Gαs信号传导对于生理和药理学上增强胰岛素分泌至关重要。

Capozzi, Megan E; Bouslov, David; Sargsyan, Ashot; Chan, Michelle Y; Chen, Alex; Gray, Sarah M; Viloria, Katrina; Bareja, Akshay; Douros, Jonathan D; Lewandowski, Sophie L; Tong, Jason Cl; Hasib, Annie; Cuozzo, Federica; Ross, Elizabeth C; Foster, Matthew W; Weinstein, Lee S; Hussain, Mehboob A; Merrins, Matthew J; Willard, Francis S; Huising, Mark O; Sloop, Kyle W; Hodson, David J; D'Alessio, David A; Campbell, Jonathan E

α cells use both PC1/3 and PC2 to process proglucagon peptides and control insulin secretion

α细胞利用PC1/3和PC2来加工胰高血糖素原肽并控制胰岛素分泌。

Cui, Canqi; Leander, Danielle C; Gray, Sarah M; El, Kimberley; Chen, Alex; Grimsrud, Paul A; Becker, Jessica O; Taylor, Austin; Zhang, Guo-Fang; Sloop, Kyle W; Verchere, C Bruce; Hoofnagle, Andrew N; D'Alessio, David A; Campbell, Jonathan E

Therapeutic Targeting of the GIP Receptor-Revisiting the Controversies

GIP受体靶向治疗——重新审视争议

Campbell, Jonathan E; Drucker, Daniel J

Glucose-dependent insulinotropic polypeptide (GIP)

葡萄糖依赖性促胰岛素多肽(GIP)

Müller, Timo D; Adriaenssens, Alice; Ahrén, Bo; Blüher, Matthias; Birkenfeld, Andreas L; Campbell, Jonathan E; Coghlan, Matthew P; D'Alessio, David; Deacon, Carolyn F; DelPrato, Stefano; Douros, Jonathan D; Drucker, Daniel J; Figueredo Burgos, Natalie S; Flatt, Peter R; Finan, Brian; Gimeno, Ruth E; Gribble, Fiona M; Hayes, Matthew R; Hölscher, Christian; Holst, Jens J; Knerr, Patrick J; Knop, Filip K; Kusminski, Christine M; Liskiewicz, Arkadiusz; Mabilleau, Guillaume; Mowery, Stephanie A; Nauck, Michael A; Novikoff, Aaron; Reimann, Frank; Roberts, Anna G; Rosenkilde, Mette M; Samms, Ricardo J; Scherer, Philip E; Seeley, Randy J; Sloop, Kyle W; Wolfrum, Christian; Wootten, Denise; DiMarchi, Richard D; Tschöp, Matthias H

Acute exogenous acyl-GIP treatment enhances lipid handling and fatty acid oxidation by involving brown fat.

急性外源性酰基-GIP治疗通过棕色脂肪参与增强脂质处理和脂肪酸氧化。

Lyons Sulayman A, Lea Micah B S, Parikh Mihir, Guo Zhengzhang, Kagdi Samrin, Bisnauth Abigail R, Pitino Jonathan R, Ziai Sabrina, Mir Negar, Tyrrell Aidan D, Fu Yan, Chen Chuck T, Metherel Adam H, Bazinet Richard P, Yang Bin, Knerr Patrick J, Douros Jonathan D, Campbell Jonathan E, Beaudry Jacqueline L

Development of a succinyl CoA:3-ketoacid CoA transferase inhibitor selective for peripheral tissues that improves glycemia in obesity.

开发一种对周围组织具有选择性的琥珀酰辅酶A:3-酮酸辅酶A转移酶抑制剂,可改善肥胖症患者的血糖水平

Tabatabaei Dakhili Seyed Amirhossein, Yang Kunyan, Al Nebaihi Hamdah, Greenwell Amanda A, Wuest Melinda, Woodfield Jenilee, Farraj Rabih Abou, Saed Christina T, Chan Jordan S F, Bhat Rakesh K, Mangra-Bala Indiresh A, Shafaati Tanin, Gopal Keshav, Eaton Farah, Ferrari Sally R, Wagg Cory S, Capozzi Megan E, Campbell Jonathan E, Overduin Michael, Velazquez-Martinez Carlos A, Glover J N Mark, Wuest Frank, Brocks Dion R, Ussher John R

Author Correction: Intra-islet α-cell Gs signaling promotes glucagon release

作者更正:胰岛内α细胞Gs信号传导促进胰高血糖素释放

Liu, Liu; Ei, Kimberley; Dattaroy, Diptadip; Barella, Luiz F; Cui, Yinghong; Gray, Sarah M; Guedikian, Carla; Chen, Min; Weinstein, Lee S; Knuth, Emily; Jin, Erli; Merrins, Matthew J; Roman, Jeffrey; Kaestner, Klaus H; Doliba, Nicolai; Campbell, Jonathan E; Wess, Jürgen

Activation of Gs signaling in mouse enteroendocrine K cells greatly improves obesity- and diabetes-related metabolic deficits

激活小鼠肠内分泌K细胞中的Gs信号通路可显著改善肥胖和糖尿病相关的代谢缺陷

Oteng, Antwi-Boasiako; Liu, Liu; Cui, Yinghong; Gavrilova, Oksana; Lu, Huiyan; Chen, Min; Weinstein, Lee S; Campbell, Jonathan E; Lewis, Jo E; Gribble, Fiona M; Reimann, Frank; Wess, Jürgen