Cryo-EM structures of GPR75 reveal an occluded orthosteric pocket challenging conventional drug discovery paradigms for an anti-obesity target
GPR75的冷冻电镜结构揭示了一个封闭的正构口袋，这挑战了传统的抗肥胖靶点药物发现模式。
期刊:Acta Pharmacologica Sinica
影响因子:8.4
doi:10.1038/s41401-025-01720-6
Zhu, Zi-Ning; You, Chong-Zhao; Yuan, Qing-Ning; Xu, Jiu-Yin; Gu, Zong-Yue; Huang, Zheng; Liu, Miao; Shan, Bei; Wang, James Jiqi; Hu, Wen; Wang, Kai; Yin, Wan-Chao; Xu, You-Wei; Xu, H Eric; Wu, Can-Rong
