日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Atrophin-1 antisense oligonucleotide provides robust protection from pathology in a fully humanized DRPLA model.

Atrophin-1 反义寡核苷酸在完全人源化的 DRPLA 模型中提供了强大的病理保护作用。

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.1
doi:10.1016/j.omtn.2025.102815
Smith Velvet L, Gidi Bereket Z, Bragg Robert M, Cantle Jeffrey P, Ben-Varon Aliza, Noble Briana, Prades Silvia, Compton Andrea, Greenfield Julie, Korecka Joanna A, Gemos Anya, Yu Timothy, Khurana Vikram, Kordasiewicz Holly B, Zhao Hien T, Barker-Haliski Melissa, Child Daniel D, Carroll Jeffrey B
Human
ATR
发表日期：2026
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Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.

通过转录抑制和直接 CAG 重复序列结合抑制亨廷顿病体细胞不稳定性。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-64936-4
Mathews Ella W, Coffey Sydney R, Gärtner Annette, Belgrad Jillian, Bragg Robert M, O'Reilly Daniel, Cantle Jeffrey P, McHugh Cassandra, Summers Ashley, Fentz Joachim, Schwagarus Tom, Cornelius Antje, Lingos Ioannis, Burch Zoe, Kovalenko Marina, Andrew Marissa A, Bennett C Frank, Kordasiewicz Holly B, Marchionini Deanna M, Wilkinson Hilary, Vogt Thomas F, Beuzer Paolo, Pinto Ricardo M, Khvorova Anastasia, Howland David, Wheeler Vanessa C, Carroll Jeffrey B
细胞生物学
发表日期：2025
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Altered huntingtin-chromatin interactions predict transcriptional and epigenetic changes in Huntington's disease.

亨廷顿蛋白-染色质相互作用的改变可预测亨廷顿病中的转录和表观遗传变化

期刊:Disease Models & Mechanisms
影响因子:3.3
doi:10.1242/dmm.052282
Pearl Jocelynn R, Shetty Amol C, Cantle Jeffrey P, Bergey Dani E, Bragg Robert M, Coffey Sydney R, Kordasiewicz Holly B, Hood Leroy E, Price Nathan D, Ament Seth A, Carroll Jeffrey B
表观遗传
发表日期：2025
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Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations

单核RNA测序揭示亨廷顿病突变导致纹状体细胞身份失调

期刊:Journal of Neuroscience
影响因子:4
doi:10.1523/JNEUROSCI.2074-20.2021
Malaiya, Sonia; Cortes-Gutierrez, Marcia; Herb, Brian R; Coffey, Sydney R; Legg, Samuel R W; Cantle, Jeffrey P; Colantuoni, Carlo; Carroll, Jeffrey B; Ament, Seth A
细胞生物学
发表日期：2021
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Corrigendum: Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt(Q111/+) model of Huntington's disease

更正：在亨廷顿病B6.Htt(Q111/+)模型中，动机、蛋白质稳态和转录缺陷先于突触丢失、胶质增生和神经退行性变发生。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/srep44960
Bragg, Robert M; Coffey, Sydney R; Weston, Rory M; Ament, Seth A; Cantle, Jeffrey P; Minnig, Shawn; Funk, Cory C; Shuttleworth, Dominic D; Woods, Emily L; Sullivan, Bonnie R; Jones, Lindsey; Glickenhaus, Anne; Anderson, John S; Anderson, Michael D; Dunnett, Stephen B; Wheeler, Vanessa C; MacDonald, Marcy E; Brooks, Simon P; Price, Nathan D; Carroll, Jeffrey B
蛋白质稳态
神经科学
发表日期：2017
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Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington's disease

在亨廷顿病B6.HttQ111/+小鼠模型中，外周亨廷顿蛋白沉默并不能改善中枢疾病症状。

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0175968
Coffey, Sydney R; Bragg, Robert M; Minnig, Shawn; Ament, Seth A; Cantle, Jeffrey P; Glickenhaus, Anne; Shelnut, Daniel; Carrillo, José M; Shuttleworth, Dominic D; Rodier, Julie-Anne; Noguchi, Kimihiro; Bennett, C Frank; Price, Nathan D; Kordasiewicz, Holly B; Carroll, Jeffrey B
发表日期：2017
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Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease

在亨廷顿病小鼠模型中，通过靶向神经元来降低突变亨廷顿蛋白的表达，从而改善疾病症状。

期刊:Nature Medicine
影响因子:50
doi:10.1038/nm.3514
Wang, Nan; Gray, Michelle; Lu, Xiao-Hong; Cantle, Jeffrey P; Holley, Sandra M; Greiner, Erin; Gu, Xiaofeng; Shirasaki, Dyna; Cepeda, Carlos; Li, Yuqing; Dong, Hongwei; Levine, Michael S; Yang, X William
神经科学
发表日期：2014
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Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis

对小鼠突变亨廷顿蛋白进行基因操作：对亨廷顿病发病机制的新见解

期刊:
影响因子:
doi:10.1111/febs.12418
Lee, C Y Daniel; Cantle, Jeffrey P; Yang, X William
发表日期：2013
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Stressin1-A, a potent corticotropin releasing factor receptor 1 (CRF1)-selective peptide agonist

Stressin1-A，一种强效的促肾上腺皮质激素释放因子受体1 (CRF1) 选择性肽激动剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/jm0613875
Rivier, Jean; Gulyas, Jozsef; Kunitake, Koichi; DiGruccio, Michael; Cantle, Jeffrey P; Perrin, Marilyn H; Donaldson, Cindy; Vaughan, Joan; Million, Mulugeta; Gourcerol, Guillaume; Adelson, David W; Rivier, Catherine; Taché, Yvette; Vale, Wylie
信号转导
免疫/内分泌
发表日期：2007
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