日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Functional inactivation of MDR3 caused by a homozygous ABCB4 missense variant leading to liver failure

由ABCB4纯合错义变异引起的MDR3功能失活导致肝功能衰竭

Heinrich, Sophia; Behrendt, Annika; Sgodda, Malte; Gohlke, Holger; Auber, Bernd; Stalke, Amelie; Hartleben, Björn; Wedemeyer, Heiner; Cantz, Tobias; Taubert, Richard

PAM-interacting domain turn-helix 51 motifs can improve Cas9-SpRY activity.

PAM 相互作用域转角螺旋 51 基序可以提高 Cas9-SpRY 的活性

Eggenschwiler Reto, Hoffmann Thomas, Dmytrenko Oleg, Opitz Mika, Ackel-Zakour Marlene, Wang Pascal, McCallan Shannon A, Fráguas-Eggenschwiler Mariane, Niemann Heiner, Patronov Atanas, Beisel Chase L, Cantz Tobias

iPSC-based hepatic organoids reveal a heterozygous MYO5B variant as driver of intrahepatic cholestasis

基于iPSC的肝脏类器官揭示了杂合MYO5B变异是肝内胆汁淤积的驱动因素

Sgodda, Malte; Gebel, Evelyn; Dignas, Lennart; Alfken, Susanne; Eggenschwiler, Reto; Stalke, Amelie; Dröge, Carola; Pfister, Evo-Doreen; Baumann, Ulrich; Luedde, Tom; Esposito, Irene; Keitel, Verena; Cantz, Tobias

A farnesoid X receptor T296I variant disrupts ligand-induced FXR activation and thus bile acid transport in progressive familial intrahepatic cholestasis.

法尼醇 X 受体 T296I 变体破坏配体诱导的 FXR 激活,从而破坏进行性家族性肝内胆汁淤积症中的胆汁酸转运。

Behrendt Annika, Bastianelli Alex, Stindt Jan, Pfister Eva-Doreen, Sgodda Malte, Cantz Tobias, Hook Sebastian, Gopalswamy Mohanraj, Grau Kathrin, Brands Stefanie, Dröge Carola, Stalke Amelie, Bonus Michele, Franke Sabine, Baumann Ulrich, Keitel Verena, Gohlke Holger

"Snip, snip, cure"? Philosophical, legal and biomedical perspectives on novel somatic genomic therapies

“一刀两断,治愈”?从哲学、法律和生物医学角度探讨新型体细胞基因组疗法

Risse, Johanna; Pietrek, Lothar; Cantz, Tobias; Krzemien, Merlin; Schnalke, Jan; Eggenschwiler, Reto; Heinemann, Thomas; Dederer, Hans-Georg

Electrophysiological Properties of Tetraploid Cardiomyocytes Derived from Murine Pluripotent Stem Cells Generated by Fusion of Adult Somatic Cells with Embryonic Stem Cells

由成体体细胞与胚胎干细胞融合产生的鼠多能干细胞衍生的四倍体心肌细胞的电生理特性

Xu, Guoxing; Fatima, Azra; Breitbach, Martin; Kuzmenkin, Alexey; Fügemann, Christopher J; Ivanyuk, Dina; Kim, Kee Pyo; Cantz, Tobias; Pfannkuche, Kurt; Schöler, Hans R; Fleischmann, Bernd K; Hescheler, Jürgen; Šarić, Tomo

MicroRNA-125b-5p Regulates Hepatocyte Proliferation During the Termination Phase of Liver Regeneration

MicroRNA-125b-5p在肝脏再生终止期调控肝细胞增殖

Yang, Dakai; Dai, Zhen; Yang, Taihua; Balakrishnan, Asha; Yuan, Qinggong; Vondran, Florian W R; Manns, Michael P; Ott, Michael; Cantz, Tobias; Sharma, Amar Deep

Human germline editing in the era of CRISPR-Cas: risk and uncertainty, inter-generational responsibility, therapeutic legitimacy

CRISPR-Cas时代人类生殖细胞编辑:风险与不确定性、代际责任、治疗合法性

Schleidgen, Sebastian; Dederer, Hans-Georg; Sgodda, Susan; Cravcisin, Stefan; Lüneburg, Luca; Cantz, Tobias; Heinemann, Thomas

The Role of microRNAs in Embryonic and Induced Pluripotency

微RNA在胚胎和诱导多能性中的作用

Beh-Pajooh, Abbas; Cantz, Tobias

Framing the ethical and legal issues of human artificial gametes in research, therapy, and assisted reproduction: A German perspective

从德国视角探讨研究、治疗和辅助生殖中人造配子的伦理和法律问题

Advena-Regnery, Barbara; Dederer, Hans-Georg; Enghofer, Franziska; Cantz, Tobias; Heinemann, Thomas