Small molecule modulation of p75(NTR) engages the autophagy-lysosomal pathway and reduces huntingtin aggregates in cellular and mouse models of Huntington's disease.

小分子调节 p75(NTR) 可激活自噬-溶酶体途径，并减少亨廷顿病细胞和小鼠模型中的亨廷顿蛋白聚集体