日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Colorectal carcinogenesis in the Lynch syndromes and familial adenomatous polyposis: trigger events and downstream consequences

林奇综合征和家族性腺瘤性息肉病中的结直肠癌发生:触发事件和后续后果

Møller, Pål; Ahadova, Aysel; Kloor, Matthias; Seppälä, Toni T; Burn, John; Haupt, Saskia; Macrae, Finlay; Dominguez-Valentin, Mev; Möslein, Gabriela; Lindblom, Annika; Sunde, Lone; Winship, Ingrid; Capella, Gabriel; Monahan, Kevin; Buchanan, Daniel D; Evans, D Gareth; Hovig, Eivind; Sampson, Julian R

Phenotype Correlations With Pathogenic DNA Variants in the MUTYH Gene: A Review of Over 2000 Cases

MUTYH基因致病性DNA变异与表型的相关性:2000多例病例回顾

Thet, Monica; Plazzer, John-Paul; Capella, Gabriel; Latchford, Andrew; Nadeau, Emily A W; Greenblatt, Marc S; Macrae, Finlay

Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated "Big Bang" pathway to CRC in three of the four Lynch syndromes

结肠镜监测下结直肠腺瘤和癌症的发生率表明,在四种林奇综合征中的三种中,结直肠癌的发生发展存在加速的“大爆炸”途径。

Møller, Pål; Haupt, Saskia; Ahadova, Aysel; Kloor, Matthias; Sampson, Julian R; Sunde, Lone; Seppälä, Toni; Burn, John; Bernstein, Inge; Capella, Gabriel; Evans, D Gareth; Lindblom, Annika; Winship, Ingrid; Macrae, Finlay; Katz, Lior; Laish, Ido; Vainer, Elez; Monahan, Kevin; Half, Elizabeth; Horisberger, Karoline; da Silva, Leandro Apolinário; Heuveline, Vincent; Therkildsen, Christina; Lautrup, Charlotte; Klarskov, Louise L; Cavestro, Giulia Martina; Möslein, Gabriela; Hovig, Eivind; Dominguez-Valentin, Mev

Phenotype correlations with pathogenic DNA variants in the MUTYH gene

MUTYH基因致病性DNA变异与表型的相关性

Thet, Monica; Plazzer, John Paul; Capella, Gabriel; Latchford, Andrew; Nadeau, Emily Aw; Greenblatt, Marc S; Macrae, Finlay

Constitutional MLH1 Methylation Is a Major Contributor to Mismatch Repair-Deficient, MLH1-Methylated Colorectal Cancer in Patients Aged 55 Years and Younger

MLH1 基因甲基化是 55 岁及以下患者发生错配修复缺陷型 MLH1 甲基化结直肠癌的主要因素。

Hitchins, Megan P; Dámaso, Estela; Alvarez, Rocio; Zhou, Lisa; Hu, Yajing; Diniz, Marcio A; Pineda, Marta; Capella, Gabriel; Pearlman, Rachel; Hampel, Heather

Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database

携带致病性错配修复基因变异并接受早期癌症诊断和治疗监测的患者的年龄、基因和性别死亡率:来自前瞻性林奇综合征数据库的报告

Dominguez-Valentin, Mev; Haupt, Saskia; Seppälä, Toni T; Sampson, Julian R; Sunde, Lone; Bernstein, Inge; Jenkins, Mark A; Engel, Christoph; Aretz, Stefan; Nielsen, Maartje; Capella, Gabriel; Balaguer, Francesc; Evans, Dafydd Gareth; Burn, John; Holinski-Feder, Elke; Bertario, Lucio; Bonanni, Bernardo; Lindblom, Annika; Levi, Zohar; Macrae, Finlay; Winship, Ingrid; Plazzer, John-Paul; Sijmons, Rolf; Laghi, Luigi; Della Valle, Adriana; Heinimann, Karl; Dębniak, Tadeusz; Fruscio, Robert; Lopez-Koestner, Francisco; Alvarez-Valenzuela, Karin; Katz, Lior H; Laish, Ido; Vainer, Elez; Vaccaro, Carlos; Carraro, Dirce Maria; Monahan, Kevin; Half, Elizabeth; Stakelum, Aine; Winter, Des; Kennelly, Rory; Gluck, Nathan; Sheth, Harsh; Abu-Freha, Naim; Greenblatt, Marc; Rossi, Benedito Mauro; Bohorquez, Mabel; Cavestro, Giulia Martina; Lino-Silva, Leonardo S; Horisberger, Karoline; Tibiletti, Maria Grazia; Nascimento, Ivana do; Thomas, Huw; Rossi, Norma Teresa; Apolinário da Silva, Leandro; Zaránd, Attila; Ruiz-Bañobre, Juan; Heuveline, Vincent; Mecklin, Jukka-Pekka; Pylvänäinen, Kirsi; Renkonen-Sinisalo, Laura; Lepistö, Anna; Peltomäki, Päivi; Therkildsen, Christina; Madsen, Mia Gebauer; Burgdorf, Stefan Kobbelgaard; Hopper, John L; Win, Aung Ko; Haile, Robert W; Lindor, Noralane; Gallinger, Steven; Le Marchand, Loïc; Newcomb, Polly A; Figueiredo, Jane; Buchanan, Daniel D; Thibodeau, Stephen N; von Knebel Doeberitz, Magnus; Loeffler, Markus; Rahner, Nils; Schröck, Evelin; Steinke-Lange, Verena; Schmiegel, Wolff; Vangala, Deepak; Perne, Claudia; Hüneburg, Robert; Redler, Silke; Büttner, Reinhard; Weitz, Jürgen; Pineda, Marta; Duenas, Nuria; Vidal, Joan Brunet; Moreira, Leticia; Sánchez, Ariadna; Hovig, Eivind; Nakken, Sigve; Green, Kate; Lalloo, Fiona; Hill, James; Crosbie, Emma; Mints, Miriam; Goldberg, Yael; Tjandra, Douglas; Ten Broeke, Sanne W; Kariv, Revital; Rosner, Guy; Advani, Suresh H; Thomas, Lidiya; Shah, Pankaj; Shah, Mithun; Neffa, Florencia; Esperon, Patricia; Pavicic, Walter; Torrezan, Giovana Tardin; Bassaneze, Thiago; Martin, Claudia Alejandra; Moslein, Gabriela; Moller, Pål

MLH1-methylated endometrial cancer under 60 years of age as the "sentinel" cancer in female carriers of high-risk constitutional MLH1 epimutation

MLH1甲基化子宫内膜癌(60岁以下)是高危体质性MLH1表观突变女性携带者的“哨兵”癌症

Hitchins, Megan P; Alvarez, Rocio; Zhou, Lisa; Aguirre, Francesca; Dámaso, Estela; Pineda, Marta; Capella, Gabriel; Wong, Justin J-L; Yuan, Xiaopu; Ryan, Shawnia R; Sathe, Devika S; Baxter, Melanie D; Cannon, Timothy; Biswas, Rakesh; DeMarco, Tiffani; Grzelak, Doreen; Hampel, Heather; Pearlman, Rachel

Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence

多基因背景、罕见致病性种系变异和家族史对结直肠癌发病率的临床相关联合影响

Hassanin, Emadeldin; Spier, Isabel; Bobbili, Dheeraj R; Aldisi, Rana; Klinkhammer, Hannah; David, Friederike; Dueñas, Nuria; Hüneburg, Robert; Perne, Claudia; Brunet, Joan; Capella, Gabriel; Nöthen, Markus M; Forstner, Andreas J; Mayr, Andreas; Krawitz, Peter; May, Patrick; Aretz, Stefan; Maj, Carlo

Phase I, multicenter, open-label study of intravenous VCN-01 oncolytic adenovirus with or without nab-paclitaxel plus gemcitabine in patients with advanced solid tumors

一项 I 期、多中心、开放标签研究,评估静脉注射 VCN-01 溶瘤腺病毒联合或不联合 nab-紫杉醇加吉西他滨治疗晚期实体瘤患者的疗效。

Garcia-Carbonero, Rocio; Bazan-Peregrino, Miriam; Gil-Martín, Marta; Álvarez, Rafael; Macarulla, Teresa; Riesco-Martinez, Maria C; Verdaguer, Helena; Guillén-Ponce, Carmen; Farrera-Sal, Martí; Moreno, Rafael; Mato-Berciano, Ana; Maliandi, Maria Victoria; Torres-Manjon, Silvia; Costa, Marcel; Del Pozo, Natalia; Martínez de Villarreal, Jaime; Real, Francisco X; Vidal, Noemí; Capella, Gabriel; Alemany, Ramon; Blasi, Emma; Blasco, Carmen; Cascalló, Manel; Salazar, Ramon

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

林奇综合征患者结直肠癌发病率:前瞻性林奇综合征数据库与国际错配修复联盟结果的比较

Møller, Pål; Seppälä, Toni; Dowty, James G; Haupt, Saskia; Dominguez-Valentin, Mev; Sunde, Lone; Bernstein, Inge; Engel, Christoph; Aretz, Stefan; Nielsen, Maartje; Capella, Gabriel; Evans, Dafydd Gareth; Burn, John; Holinski-Feder, Elke; Bertario, Lucio; Bonanni, Bernardo; Lindblom, Annika; Levi, Zohar; Macrae, Finlay; Winship, Ingrid; Plazzer, John-Paul; Sijmons, Rolf; Laghi, Luigi; Valle, Adriana Della; Heinimann, Karl; Half, Elizabeth; Lopez-Koestner, Francisco; Alvarez-Valenzuela, Karin; Scott, Rodney J; Katz, Lior; Laish, Ido; Vainer, Elez; Vaccaro, Carlos Alberto; Carraro, Dirce Maria; Gluck, Nathan; Abu-Freha, Naim; Stakelum, Aine; Kennelly, Rory; Winter, Des; Rossi, Benedito Mauro; Greenblatt, Marc; Bohorquez, Mabel; Sheth, Harsh; Tibiletti, Maria Grazia; Lino-Silva, Leonardo S; Horisberger, Karoline; Portenkirchner, Carmen; Nascimento, Ivana; Rossi, Norma Teresa; da Silva, Leandro Apolinário; Thomas, Huw; Zaránd, Attila; Mecklin, Jukka-Pekka; Pylvänäinen, Kirsi; Renkonen-Sinisalo, Laura; Lepisto, Anna; Peltomäki, Päivi; Therkildsen, Christina; Lindberg, Lars Joachim; Thorlacius-Ussing, Ole; von Knebel Doeberitz, Magnus; Loeffler, Markus; Rahner, Nils; Steinke-Lange, Verena; Schmiegel, Wolff; Vangala, Deepak; Perne, Claudia; Hüneburg, Robert; de Vargas, Aída Falcón; Latchford, Andrew; Gerdes, Anne-Marie; Backman, Ann-Sofie; Guillén-Ponce, Carmen; Snyder, Carrie; Lautrup, Charlotte K; Amor, David; Palmero, Edenir; Stoffel, Elena; Duijkers, Floor; Hall, Michael J; Hampel, Heather; Williams, Heinric; Okkels, Henrik; Lubiński, Jan; Reece, Jeanette; Ngeow, Joanne; Guillem, Jose G; Arnold, Julie; Wadt, Karin; Monahan, Kevin; Senter, Leigha; Rasmussen, Lene J; van Hest, Liselotte P; Ricciardiello, Luigi; Kohonen-Corish, Maija R J; Ligtenberg, Marjolijn J L; Southey, Melissa; Aronson, Melyssa; Zahary, Mohd N; Samadder, N Jewel; Poplawski, Nicola; Hoogerbrugge, Nicoline; Morrison, Patrick J; James, Paul; Lee, Grant; Chen-Shtoyerman, Rakefet; Ankathil, Ravindran; Pai, Rish; Ward, Robyn; Parry, Susan; Dębniak, Tadeusz; John, Thomas; van Overeem Hansen, Thomas; Caldés, Trinidad; Yamaguchi, Tatsuro; Barca-Tierno, Verónica; Garre, Pilar; Cavestro, Giulia Martina; Weitz, Jürgen; Redler, Silke; Büttner, Reinhard; Heuveline, Vincent; Hopper, John L; Win, Aung Ko; Lindor, Noralane; Gallinger, Steven; Le Marchand, Loïc; Newcomb, Polly A; Figueiredo, Jane; Buchanan, Daniel D; Thibodeau, Stephen N; Ten Broeke, Sanne W; Hovig, Eivind; Nakken, Sigve; Pineda, Marta; Dueñas, Nuria; Brunet, Joan; Green, Kate; Lalloo, Fiona; Newton, Katie; Crosbie, Emma J; Mints, Miriam; Tjandra, Douglas; Neffa, Florencia; Esperon, Patricia; Kariv, Revital; Rosner, Guy; Pavicic, Walter Hernán; Kalfayan, Pablo; Torrezan, Giovana Tardin; Bassaneze, Thiago; Martin, Claudia; Moslein, Gabriela; Ahadova, Aysel; Kloor, Matthias; Sampson, Julian R; Jenkins, Mark A