日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Haplotype editing with CRISPR-Cas9 as a therapeutic approach for dominant-negative missense mutations in NEFL

利用 CRISPR-Cas9 进行单倍型编辑作为治疗 NEFL 中显性负性错义突变的治疗方法

Dua, Poorvi H; Simon, Bazilco M J; Marley, Chiara B E; Feliciano, Carissa M; Watry, Hannah L; Cowan, Quinn T; Steury, Dylan; Abraham, Abin; Gilbertson, Erin N; Ramey, Grace D; Capra, John A; Conklin, Bruce R; Judge, Luke M

Use of Paracervical Blocks for Patients Who Undergo Intrauterine Device Insertion

对接受宫内节育器放置术的患者使用宫颈旁阻滞麻醉

Roger, Jacquelyn M; Costello, Jean; Young, Halle; Malave-Mendez, Thaybeth I; Miao, Brenda Y; Brindis, Claire D; Meckstroth, Karen; Hernandez, Ryan D; Whetstone, Sara; Raymond-Flesch, Marissa; Capra, John A; Glymour, M Maria; Torgerson, Dara

AncientProxy: A catalog of ancient proxies for modern genetic variants

AncientProxy:现代基因变异的古代替代基因目录

Brand, Colin M; Capra, John A

Comparing Neanderthal Introgression Maps Reveals Core Agreement But Substantial Heterogeneity

比较尼安德特人基因渗入图谱揭示了核心共识,但也存在显著异质性

Chen, Yaen; Velazquez-Arcelay, Keila; Capra, John A

Social and Cardiovascular Risk Factors as Predictors of the Progression from Mild Cognitive Impairment to Dementia in a Large EHR Database

在大型电子健康记录数据库中,社会和心血管风险因素作为轻度认知障碍进展为痴呆的预测因子

Miramontes, Silvia; Ferguson, Erin L; Zimmerman, Scott; Phelps, Evan; Oskotsky, Boris; Oskotsky, Tomiko T; Capra, John A; Tsoy, Elena; Sirota, Marina; Glymour, M Maria

Leveraging human genetic variation to therapeutically target hundreds of genes with dominant & dispensable disease alleles

利用人类遗传变异,以治疗为目标,靶向数百个具有显性和非显性致病等位基因的基因。

Ramey, Grace D; Cowan, Quinn T; Saxena, Akshita G; Macklin, Bria L; Watry, Hannah L; Mei, Xiaoyue; Dierks, Philip; Judge, Luke M; Conklin, Bruce R; Capra, John A

Comparing chromatin contact maps at scale: methods and insights

大规模比较染色质接触图谱:方法与见解

Gjoni, Ketrin; Gunsalus, Laura M; Kuang, Shuzhen; McArthur, Evonne; Pittman, Maureen; Capra, John A; Pollard, Katherine S

Exposure to autoimmune disorders is associated with increased Alzheimer's disease risk in a multi-site electronic health record analysis

一项多中心电子健康记录分析显示,自身免疫性疾病的暴露与阿尔茨海默病风险增加相关。

Ramey, Grace D; Tang, Alice; Phongpreecha, Thanaphong; Yang, Monica M; Woldemariam, Sarah R; Oskotsky, Tomiko T; Montine, Thomas J; Allen, Isabel; Miller, Zachary A; Aghaeepour, Nima; Capra, John A; Sirota, Marina

Identifying deleterious noncoding variation through gain and loss of CTCF binding activity

通过CTCF结合活性的获得和丧失来识别有害的非编码变异

Tubbs, Colby; Benton, Mary Lauren; McArthur, Evonne; Capra, John A; Ruderfer, Douglas M

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning.

通过深度突变扫描绘制MET受体酪氨酸激酶的激酶结构域抗性机制图谱

Estevam Gabriella O, Linossi Edmond, Rao Jingyou, Macdonald Christian B, Ravikumar Ashraya, Chrispens Karson M, Capra John A, Coyote-Maestas Willow, Pimentel Harold, Collisson Eric A, Jura Natalia, Fraser James S