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Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes

抗PD-1疗法可触发Tfh细胞依赖性IL-4释放，从而增强肿瘤引流淋巴结中的CD8 T细胞反应。

doi:10.1084/jem.20232104

Ruggiu, Mathilde; Guérin, Marion V; Corre, Béatrice; Bardou, Margot; Alonso, Ruby; Russo, Erica; Garcia, Zacarias; Feldmann, Lea; Lemaître, Fabrice; Dusseaux, Mathilde; Grandjean, Capucine L; Bousso, Philippe

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity

肿瘤对 IFN-γ 促凋亡作用的内在敏感性是 CD4+ CAR T 细胞抗肿瘤活性的主要决定因素

期刊:Nature Cancer

影响因子:23.5

doi:10.1038/s43018-023-00570-7

Morgane Boulch, Marine Cazaux, Alexis Cuffel, Marion V Guerin, Zacarias Garcia, Ruby Alonso, Fabrice Lemaître, Alexander Beer, Béatrice Corre, Laurie Menger, Capucine L Grandjean, Florence Morin, Catherine Thieblemont, Sophie Caillat-Zucman, Philippe Bousso

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity

CAR-T 细胞亚群与肿瘤微环境之间的相互作用对于持续的细胞毒活性至关重要

期刊:Science Immunology

影响因子:17.6

doi:10.1126/sciimmunol.abd4344

Morgane Boulch, Marine Cazaux, Yann Loe-Mie, Ronan Thibaut, Béatrice Corre, Fabrice Lemaître, Capucine L Grandjean, Zacarias Garcia, Philippe Bousso

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis

对抗 CD20 治疗机制的体内成像揭示了抗体依赖性吞噬作用的时空瓶颈

期刊:Science Advances

影响因子:11.7

doi:10.1126/sciadv.abd6167

Capucine L Grandjean, Zacarias Garcia, Fabrice Lemaître, Béatrice Bréart, Philippe Bousso

信号转导

发表日期：2021

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Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity

CAR-T 细胞体内活性的单细胞成像揭示了广泛的功能和解剖异质性

期刊:Journal of Experimental Medicine

影响因子:12.6

doi:10.1084/jem.20182375

Marine Cazaux, Capucine L Grandjean, Fabrice Lemaître, Zacarias Garcia, Richard J Beck, Idan Milo, Jérémy Postat, Joost B Beltman, Eleanor J Cheadle, Philippe Bousso

Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells

强烈的TCRγδ信号抑制胸腺中分泌IL-17A的γδ T细胞的发育

期刊:Cell Reports

影响因子:6.9

doi:10.1016/j.celrep.2017.05.071

Sumaria, Nital; Grandjean, Capucine L; Silva-Santos, Bruno; Pennington, Daniel J

Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies

活体成像显示，糖基工程改造的抗CD20抗体的作用机制之一是增强库普弗细胞介导的吞噬作用。

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/srep34382

Grandjean, Capucine L; Montalvao, Fabricio; Celli, Susanna; Michonneau, David; Breart, Beatrice; Garcia, Zacarias; Perro, Mario; Freytag, Olivier; Gerdes, Christian A; Bousso, Philippe

Heterogeneous yet stable Vδ2(+) T-cell profiles define distinct cytotoxic effector potentials in healthy human individuals

异质但稳定的 Vδ2(+) T 细胞谱决定了健康人类个体中不同的细胞毒效应潜能

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:

doi:10.1073/pnas.1611098113

Paul L Ryan, Nital Sumaria, Christopher J Holland, Claire M Bradford, Natalia Izotova, Capucine L Grandjean, Ali S Jawad, Lesley A Bergmeier, Daniel J Pennington

Reprogramming RIPK3-induced cell death in malignant B cells promotes immune-mediated tumor control

RIPK3诱导的恶性B细胞死亡的重编程可促进免疫介导的肿瘤控制

Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes

抗PD-1疗法可触发Tfh细胞依赖性IL-4释放，从而增强肿瘤引流淋巴结中的CD8 T细胞反应。

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity

肿瘤对 IFN-γ 促凋亡作用的内在敏感性是 CD4+ CAR T 细胞抗肿瘤活性的主要决定因素

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity

CAR-T 细胞亚群与肿瘤微环境之间的相互作用对于持续的细胞毒活性至关重要

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis

对抗 CD20 治疗机制的体内成像揭示了抗体依赖性吞噬作用的时空瓶颈

Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity

CAR-T 细胞体内活性的单细胞成像揭示了广泛的功能和解剖异质性

Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells

强烈的TCRγδ信号抑制胸腺中分泌IL-17A的γδ T细胞的发育

Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies

活体成像显示，糖基工程改造的抗CD20抗体的作用机制之一是增强库普弗细胞介导的吞噬作用。

Heterogeneous yet stable Vδ2(+) T-cell profiles define distinct cytotoxic effector potentials in healthy human individuals

异质但稳定的 Vδ2(+) T 细胞谱决定了健康人类个体中不同的细胞毒效应潜能