日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Two Structurally Distinct Classes of Inhibitors Targeting the Nuclease MUS81 and Enhancing Efficacy of Chemotherapy in Cancer Cells

发现两类结构不同的MUS81核酸酶抑制剂,可增强化疗对癌细胞的疗效

Prochazkova, Jana; Carbain, Benoit; Marini, Victoria; Nikulenkov, Fedor; Havel, Stepan; Akavaram, Naresh; Khirsariya, Prashant; Sisakova, Alexandra; Cibulka, Jakub; Boudova, Michala; Zacpalova, Magdalena; Kalovska, Magdalena; Rodrigues, Joana; Daniel, Lukas; Brezovsky, Jan; Bartunek, Petr; Azzalin, Claus; Paruch, Kamil; Krejci, Lumir

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines

细胞周期蛋白依赖性激酶 (CDK) 抑制剂:结构-活性关系以及对 6-取代 2-芳氨基嘌呤的 CDK-2 选择性的见解

Christopher R Coxon, Elizabeth Anscombe, Suzannah J Harnor, Mathew P Martin, Benoit Carbain, Bernard T Golding, Ian R Hardcastle, Lisa K Harlow, Svitlana Korolchuk, Christopher J Matheson, David R Newell, Martin E M Noble, Mangaleswaran Sivaprakasam, Susan J Tudhope, David M Turner, Lan Z Wang, Step

Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles

Nek2 不可逆抑制的模型系统:硫醇加成到乙炔嘌呤和相关的取代杂环上

Honorine Lebraud, Christopher R Coxon, Victoria S Archard, Carlo M Bawn, Benoit Carbain, Christopher J Matheson, David M Turner, Celine Cano, Roger J Griffin, Ian R Hardcastle, Ulrich Baisch, Ross W Harrington, Bernard T Golding