日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Design of sensitive monospecific and bispecific synthetic chimeric T cell receptors for cancer therapy

设计用于癌症治疗的敏感单特异性和双特异性合成嵌合T细胞受体

Sylvain Simon # ,Grace Bugos # ,Rachel Prins ,Anusha Rajan ,Arulmozhi Palani ,Kersten Heyer ,Andrew Stevens ,Longhui Zeng ,Kirsten A Thompson ,Pinar A Atilla ,Jason P Price ,Mitchell G Kluesner ,Carla A Jaeger-Ruckstuhl ,Tamer B Shabaneh ,James M Olson ,Xiaolei Su ,Stanley R Riddell

Phase I Study of ROR1-Specific CAR-T Cells in Advanced Hematopoietic and Epithelial Malignancies

ROR1特异性CAR-T细胞治疗晚期造血系统和上皮恶性肿瘤的I期研究

Carla A Jaeger-Ruckstuhl # ,Jennifer M Specht # ,Jenna M Voutsinas ,Hugh R MacMillan ,Qian Vicky Wu ,Vishaka Muhunthan ,Carolina Berger ,Shalini Pullarkat ,Jocelyn H Wright ,Cecilia C S Yeung ,Teresa S Hyun ,Brandon Seaton ,Lauri D Aicher ,Xiaoling Song ,Robert H Pierce ,Yun Lo ,Gabriel O Cole ,Sylvia M Lee ,Evan W Newell ,David G Maloney # ,Stanley R Riddell #

IL-33/ST2 signaling in ILC2s drives exhaustion and myeloid skewing of HSCs in response to hematopoietic stress and aging

IL-33/ST2信号通路在ILC2细胞中驱动造血干细胞耗竭和髓系分化,以应对造血应激和衰老。

Pascal Naef ,Carla A Jaeger-Ruckstuhl ,Noah Schnüriger ,Stefan Forster ,Inês Monteiro ,Daniel Brigger ,Alexander Eggel ,Kai Kessenbrock ,Carsten Riether ,Adrian F Ochsenbein

Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks

初始T细胞活化过程中,CD27-TRAF2-SHP-1轴信号通路促进记忆相关基因调控网络的形成。

Carla A Jaeger-Ruckstuhl ,Yun Lo ,Elena Fulton ,Olivia G Waltner ,Tamer B Shabaneh ,Sylvain Simon ,Pranav V Muthuraman ,Colin E Correnti ,Oliver J Newsom ,Ian A Engstrom ,Sami B Kanaan ,Shruti S Bhise ,Jobelle M C Peralta ,Raymond Ruff ,Jason P Price ,Sylvia M Stull ,Andrew R Stevens ,Grace Bugos ,Mitchell G Kluesner ,Valentin Voillet ,Vishaka Muhunthan ,Fionnuala Morrish ,James M Olson ,Raphaël Gottardo ,Jay F Sarthy ,Steven Henikoff ,Lucas B Sullivan ,Scott N Furlan ,Stanley R Riddell

Systemically administered low-affinity HER2 CAR T cells mediate antitumor efficacy without toxicity

系统性给药低亲和力 HER2 CAR-T 细胞可介导抗肿瘤功效且无毒性

Tamer Basel Shabaneh, Andrew R Stevens, Sylvia M Stull, Kristen R Shimp, Brandon W Seaton, Ekram A Gad, Carla A Jaeger-Ruckstuhl, Sylvain Simon, Amanda L Koehne, Jason P Price, James M Olson, Benjamin G Hoffstrom, David Jellyman, Stanley R Riddell

qPCR assay for detection of Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Elements from CAR-T and TCR-T cells in fresh and formalin-fixed tissue

qPCR 检测新鲜和福尔马林固定组织中的 CAR-T 和 TCR-T 细胞中的土拨鼠肝炎病毒转录后调控元件

Shalini Pullarkat, Graeme Black, Marie Bleakley, Denise Buenrostro, Aude G Chapuis, Alexandre V Hirayama, Carla A Jaeger-Ruckstuhl, Erik L Kimble, Bo M Lee, David G Maloney, Jerald Radich, Brandon W Seaton, Jennifer M Specht, Cameron J Turtle, David W Woolston, Jocelyn H Wright, Cecilia C S Yeung

IL-33-ST2 signaling promotes stemness in subtypes of myeloid leukemia cells through the Wnt and Notch pathways

IL-33-ST2 信号通过 Wnt 和 Notch 通路促进髓系白血病细胞亚型的干细胞性

Pascal Naef, Ramin Radpour, Carla A Jaeger-Ruckstuhl, Nils Bodmer, Gabriela M Baerlocher, Hartmut Doehner, Konstanze Doehner, Carsten Riether, Adrian F Ochsenbein

Therapeutic targeting of tumor spheroids in a 3D microphysiological renal cell carcinoma-on-a-chip system

3D 微生理肾细胞癌芯片系统中肿瘤球体的治疗靶向

Chris P Miller, Megan Fung, Carla A Jaeger-Ruckstuhl, Yuexin Xu, Edus H Warren, Shreeram Akilesh, Scott S Tykodi

Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade

免疫原性化疗可增强 CAR-T 细胞向肺肿瘤的募集,并与免疫检查点阻断疗法联合使用时提高抗肿瘤疗效。

Shivani Srivastava ,Scott N Furlan ,Carla A Jaeger-Ruckstuhl ,Megha Sarvothama ,Carolina Berger ,Kimberly S Smythe ,Sarah M Garrison ,Jennifer M Specht ,Sylvia M Lee ,Robert A Amezquita ,Valentin Voillet ,Vishaka Muhunthan ,Sushma Yechan-Gunja ,Smitha P S Pillai ,Christoph Rader ,A McGarry Houghton ,Robert H Pierce ,Raphael Gottardo ,David G Maloney ,Stanley R Riddell

TNIK signaling imprints CD8+ T cell memory formation early after priming

TNIK信号通路在启动后早期就对CD8+ T细胞记忆的形成产生影响

Carla A Jaeger-Ruckstuhl #,Magdalena Hinterbrandner #,Sabine Höpner,Colin E Correnti,Ursina Lüthi,Olivier Friedli,Stefan Freigang,Mohamad F Al Sayed,Elias D Bührer,Michael A Amrein,Christian M Schürch,Ramin Radpour,Carsten Riether,Adrian F Ochsenbein