日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pharmacokinetic-pharmacodynamic-efficacy modeling of the MDM2 inhibitor brigimadlin in glioblastoma patient-derived xenografts

MDM2抑制剂brigimadlin在胶质母细胞瘤患者来源异种移植模型中的药代动力学-药效学-疗效模型

Vaubel, Rachael A; Zhang, Wenjuan; Karbhari, Nishika; Oh, Ju-Hee; Waller, Katie L; Mladek, Ann; Jain, Sonia; Burgenske, Danielle M; Decker, Paul A; Kosel, Matt L; Hu, Zeng; Ott, Lauren L; Carlson, Brett L; Bakken, Katrina K; Pasa, Tugce; Sarkaria, Nicole R; Talele, Surabhi; Eckel-Passow, Jeanette E; Sini, Patrizia; Elmquist, William F; Sarkaria, Jann N

The impact of therapeutic radiation on drug distribution across the blood-brain barrier in normal mouse brain and orthotopic glioblastoma tumors

治疗性辐射对正常小鼠脑组织和原位胶质母细胞瘤中药物通过血脑屏障分布的影响

Zhang, Wenjuan; Grams, Michael P; Oberoi, Rajneet K; Oh, Ju-Hee; Decker, Paul A; Sio, Terence T; Talele, Surabhi; Wilson, Zachary C; Connors, Margaret A; Bakken, Katrina K; Carlson, Brett L; Ott, Lauren L; Burgenske, Danielle M; Tryggestad, Erik J; Eckel Passow, Jeanette E; Elmquist, William F; Sarkaria, Jann N

The novel brain penetrant ataxia-telangiectasia mutated inhibitor WSD0628 provides robust radiosensitization of brain tumor patient-derived xenografts

新型脑穿透性共济失调毛细血管扩张症突变抑制剂WSD0628可显著增强脑肿瘤患者来源异种移植瘤的放射敏感性。

Xue, Zhiyi; Mladek, Ann C; Rathi, Sneha; Jain, Sonia; Vaubel, Rachael A; Odukoya, Lateef A; Garcia, Darwin A; Liu, Lily; Bakken, Katrina K; Carlson, Brett L; Ott, Lauren L; Burgenske, Danielle M; Hu, Zeng; Dragojevic, Sonja; Decker, Paul A; Kosel, Matthew L; Breen, William G; Gupta, Shiv K; Eckel-Passow, Jeanette E; Elmquist, William F; Zhong, Wei; Sarkaria, Jann N

Preclinical Modeling of Navtemadlin Pharmacokinetics, Pharmacodynamics, and Efficacy in IDH-Wild-type Glioblastoma.

Navtemadlin 在 IDH 野生型胶质母细胞瘤中的药代动力学、药效学和疗效的临床前模型

Vaubel Rachael A, Zhang Wenjuan, Oh Ju-Hee, Mladek Ann C, Pasa Tugce I, Gantchev Jennifer K, Waller Katie L, Baquer Gerard, Stopka Sylwia A, Regan Michael S, Hossain Md Amin, Decker Paul A, Kosel Matthew L, Gupta Shiv K, Jain Sonia, Sarkaria Paige P, Hu Zeng, Ott Lauren L, Carlson Brett L, Bakken Katie K, Talele Surabhi, Zhang Wenqiu, Ligon Keith L, Lee Eudocia Q, Eckel Passow Jeanette E, Burgenske Danielle M, Agar Nathalie Y R, Elmquist William F, Sarkaria Jann N

Modeling the Acute Mucosal Toxicity of Fractionated Radiotherapy Combined with the ATM Inhibitor WSD0628

分次放射治疗联合 ATM 抑制剂 WSD0628 的急性黏膜毒性模型

Garcia, Darwin A; Rathi, Sneha; Connors, Margaret A; Grams, Michael; Vaubel, Rachael A; Bakken, Katrina K; Ott, Lauren L; Carlson, Brett L; Hu, Zeng; Decker, Paul A; Eckel-Passow, Jeanette E; Burgenske, Danielle M; Zhong, Wei; Trzasko, Joshua D; Herman, Michael G; Elmquist, William F; Remmes, Nicholas B; Sarkaria, Jann N

DNA-PK Inhibition Shows Differential Radiosensitization in Orthotopic GBM PDX Models Based on DDR Pathway Deficits.

基于 DDR 通路缺陷的原位 GBM PDX 模型中 DNA-PK 抑制剂表现出不同的放射增敏作用

Dragojevic Sonja, Smith Emily J, Regan Michael S, Stopka Sylwia A, Baquer Gerard, Xue Zhiyi, Zhang Wenjuan, Connors Margaret A, Kloeber Jake A, Hu Zeng, Bakken Katrina K, Ott Lauren L, Carlson Brett L, Burgenske Danielle M, Decker Paul A, Tian Shulan, Gupta Shiv K, Laverty Daniel J, Eckel-Passow Jeanette E, Elmquist William F, Agar Nathalie Y R, Nagel Zachary D, Sarkaria Jann N, Callaghan Cameron M

Optimizing procedures for ocular radiation injury studies in the tree shrew

优化树鼩眼部放射损伤研究程序

Dalvin, Lauren A; Anderson, Kjersten J; Rinkoski, Tommy A; Miley, David R; Ong, Hien; Schechinger, Angela M; Fjeld, Cassandra A; Leblond, Catherine R; Keown, Mackenzie K; Palmer, Sierra D; Burgenske, Danielle M; Carlson, Brett L; Ott, Lauren L; Samuels, Brian C; Romero, Michael F; Sarkaria, Jann N; Boynton, Felicia Duke; Roddy, Gavin W

Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization

异常的ATM信号传导和同源定向DNA修复是p53突变型GBM对AZD1390介导的放射增敏作用的脆弱性

Chen, Jiajia; Laverty, Daniel J; Talele, Surabhi; Bale, Ashwin; Carlson, Brett L; Porath, Kendra A; Bakken, Katrina K; Burgenske, Danielle M; Decker, Paul A; Vaubel, Rachael A; Eckel-Passow, Jeanette E; Bhargava, Rohit; Lou, Zhenkun; Hamerlik, Petra; Harley, Brendan; Elmquist, William F; Nagel, Zachary D; Gupta, Shiv K; Sarkaria, Jann N

Differential Distribution of the DNA-PKcs Inhibitor Peposertib Selectively Radiosensitizes Patient-derived Melanoma Brain Metastasis Xenografts

DNA-PKcs抑制剂Peposertib的差异性分布选择性地增强患者来源的黑色素瘤脑转移异种移植瘤的放射敏感性

Ji, Jianxiong; Dragojevic, Sonja; Callaghan, Cameron M; Smith, Emily J; Talele, Surabhi; Zhang, Wenjuan; Connors, Margaret A; Mladek, Ann C; Hu, Zeng; Bakken, Katrina K; Sarkaria, Paige P; Carlson, Brett L; Burgenske, Danielle M; Decker, Paul A; Rashid, Mohammad Abdur; Jang, Mi-Hyeon; Gupta, Shiv K; Eckel-Passow, Jeanette E; Elmquist, William F; Sarkaria, Jann N

Factors Influencing the Central Nervous System (CNS) Distribution of the Ataxia Telangiectasia Mutated and Rad3-Related Inhibitor Elimusertib (BAY1895344): Implications for the Treatment of CNS Tumors

影响共济失调毛细血管扩张症突变及Rad3相关抑制剂Elimusertib (BAY1895344)在中枢神经系统(CNS)分布的因素:对中枢神经系统肿瘤治疗的启示

Rathi, Sneha; Mladek, Ann C; Oh, Ju-Hee; Dragojevic, Sonja; Burgenske, Danielle M; Zhang, Wenjuan; Talele, Surabhi; Zhang, Wenqiu; Bakken, Katrina K; Carlson, Brett L; Connors, Margaret A; He, Lihong; Hu, Zeng; Sarkaria, Jann N; Elmquist, William F