日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders

绵羊感染如何揭示阿尔茨海默病和其他神经退行性疾病中的朊病毒机制

Carlson, George A; Prusiner, Stanley B

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints

降低朊病毒蛋白水平是一种能够改善朊病毒疾病各个阶段、毒株和终点的疾病治疗手段。

Minikel, Eric Vallabh; Zhao, Hien T; Le, Jason; O'Moore, Jill; Pitstick, Rose; Graffam, Samantha; Carlson, George A; Kavanaugh, Michael P; Kriz, Jasna; Kim, Jae Beom; Ma, Jiyan; Wille, Holger; Aiken, Judd; McKenzie, Deborah; Doh-Ura, Katsumi; Beck, Matthew; O'Keefe, Rhonda; Stathopoulos, Jacquelyn; Caron, Tyler; Schreiber, Stuart L; Carroll, Jeffrey B; Kordasiewicz, Holly B; Cabin, Deborah E; Vallabh, Sonia M

Core transcriptional regulatory circuits in prion diseases

朊病毒疾病中的核心转录调控回路

Kim, Taek-Kyun; Lee, Inyoul; Cho, Ji-Hoon; Canine, Brenda; Keller, Andrew; Price, Nathan D; Hwang, Daehee; Carlson, George; Hood, Leroy

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo

在β-淀粉样蛋白存在的情况下,tau蛋白的减少可以预防体内tau蛋白病理和神经元死亡。

DeVos, Sarah L; Corjuc, Bianca T; Commins, Caitlin; Dujardin, Simon; Bannon, Riley N; Corjuc, Diana; Moore, Benjamin D; Bennett, Rachel E; Jorfi, Mehdi; Gonzales, Jose A; Dooley, Patrick M; Roe, Allyson D; Pitstick, Rose; Irimia, Daniel; Frosch, Matthew P; Carlson, George A; Hyman, Bradley T

Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides

脑血管周围巨噬细胞启动阿尔茨海默病Aβ肽引起的神经血管功能障碍

Park, Laibaik; Uekawa, Ken; Garcia-Bonilla, Lidia; Koizumi, Kenzo; Murphy, Michelle; Pistik, Rose; Younkin, Linda; Younkin, Steven; Zhou, Ping; Carlson, George; Anrather, Josef; Iadecola, Costantino

Neurodegenerative Disease Transmission and Transgenesis in Mice

小鼠神经退行性疾病的遗传和转基因

Dugger, Brittany N; Perl, Daniel P; Carlson, George A

High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds

在多种遗传背景下,对亨廷顿病CAG敲入小鼠的早期转录组、分子和细胞表型进行高分辨率时间序列映射

Ament, Seth A; Pearl, Jocelynn R; Grindeland, Andrea; St Claire, Jason; Earls, John C; Kovalenko, Marina; Gillis, Tammy; Mysore, Jayalakshmi; Gusella, James F; Lee, Jong-Min; Kwak, Seung; Howland, David; Lee, Min Young; Baxter, David; Scherler, Kelsey; Wang, Kai; Geman, Donald; Carroll, Jeffrey B; MacDonald, Marcy E; Carlson, George; Wheeler, Vanessa C; Price, Nathan D; Hood, Leroy E

Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis

在肾痨模型中,通过药物或基因手段抑制 CDK5 来缩短纤毛长度可减轻多囊肾病。

Husson, Hervé; Moreno, Sarah; Smith, Laurie A; Smith, Mandy M; Russo, Ryan J; Pitstick, Rose; Sergeev, Mikhail; Ledbetter, Steven R; Bukanov, Nikolay O; Lane, Monica; Zhang, Kate; Billot, Katy; Carlson, George; Shah, Jagesh; Meijer, Laurent; Beier, David R; Ibraghimov-Beskrovnaya, Oxana

Improvement of ENU Mutagenesis Efficiency Using Serial Injection and Mismatch Repair Deficiency Mice

利用连续注射和错配修复缺陷小鼠提高ENU诱变效率

Gallego-Llamas, Jabier; Timms, Andrew E; Pitstick, Rose; Peters, Janet; Carlson, George A; Beier, David R

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

去除内源性tau蛋白并不能阻止tau蛋白的增殖,但可以降低其神经毒性。

Wegmann, Susanne; Maury, Eduardo A; Kirk, Molly J; Saqran, Lubna; Roe, Allyson; DeVos, Sarah L; Nicholls, Samantha; Fan, Zhanyun; Takeda, Shuko; Cagsal-Getkin, Ozge; William, Christopher M; Spires-Jones, Tara L; Pitstick, Rose; Carlson, George A; Pooler, Amy M; Hyman, Bradley T