日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders

绵羊感染如何揭示阿尔茨海默病和其他神经退行性疾病中的朊病毒机制

Carlson, George A; Prusiner, Stanley B

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints

降低朊病毒蛋白水平是一种能够改善朊病毒疾病各个阶段、毒株和终点的疾病治疗手段。

Minikel, Eric Vallabh; Zhao, Hien T; Le, Jason; O'Moore, Jill; Pitstick, Rose; Graffam, Samantha; Carlson, George A; Kavanaugh, Michael P; Kriz, Jasna; Kim, Jae Beom; Ma, Jiyan; Wille, Holger; Aiken, Judd; McKenzie, Deborah; Doh-Ura, Katsumi; Beck, Matthew; O'Keefe, Rhonda; Stathopoulos, Jacquelyn; Caron, Tyler; Schreiber, Stuart L; Carroll, Jeffrey B; Kordasiewicz, Holly B; Cabin, Deborah E; Vallabh, Sonia M

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo

在β-淀粉样蛋白存在的情况下,tau蛋白的减少可以预防体内tau蛋白病理和神经元死亡。

DeVos, Sarah L; Corjuc, Bianca T; Commins, Caitlin; Dujardin, Simon; Bannon, Riley N; Corjuc, Diana; Moore, Benjamin D; Bennett, Rachel E; Jorfi, Mehdi; Gonzales, Jose A; Dooley, Patrick M; Roe, Allyson D; Pitstick, Rose; Irimia, Daniel; Frosch, Matthew P; Carlson, George A; Hyman, Bradley T

Neurodegenerative Disease Transmission and Transgenesis in Mice

小鼠神经退行性疾病的遗传和转基因

Dugger, Brittany N; Perl, Daniel P; Carlson, George A

Improvement of ENU Mutagenesis Efficiency Using Serial Injection and Mismatch Repair Deficiency Mice

利用连续注射和错配修复缺陷小鼠提高ENU诱变效率

Gallego-Llamas, Jabier; Timms, Andrew E; Pitstick, Rose; Peters, Janet; Carlson, George A; Beier, David R

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

去除内源性tau蛋白并不能阻止tau蛋白的增殖,但可以降低其神经毒性。

Wegmann, Susanne; Maury, Eduardo A; Kirk, Molly J; Saqran, Lubna; Roe, Allyson; DeVos, Sarah L; Nicholls, Samantha; Fan, Zhanyun; Takeda, Shuko; Cagsal-Getkin, Ozge; William, Christopher M; Spires-Jones, Tara L; Pitstick, Rose; Carlson, George A; Pooler, Amy M; Hyman, Bradley T

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease

在早期阿尔茨海默病模型中,淀粉样蛋白加速了tau蛋白的增殖和毒性。

Pooler, Amy M; Polydoro, Manuela; Maury, Eduardo A; Nicholls, Samantha B; Reddy, Snigdha M; Wegmann, Susanne; William, Christopher; Saqran, Lubna; Cagsal-Getkin, Ozge; Pitstick, Rose; Beier, David R; Carlson, George A; Spires-Jones, Tara L; Hyman, Bradley T

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model

内嗅皮层中可溶性病理性tau蛋白会导致早期阿尔茨海默病模型中的突触前功能障碍

Polydoro, Manuela; Dzhala, Volodymyr I; Pooler, Amy M; Nicholls, Samantha B; McKinney, A Patrick; Sanchez, Laura; Pitstick, Rose; Carlson, George A; Staley, Kevin J; Spires-Jones, Tara L; Hyman, Bradley T

Development of a novel cellular model of Alzheimer's disease utilizing neurosphere cultures derived from B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J embryonic mouse brain

利用源自B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J胚胎小鼠脑的神经球培养物,构建阿尔茨海默病的新型细胞模型

Ghate, Pankaj S; Sidhar, Himakshi; Carlson, George A; Giri, Ranjit K

Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy

亚甲蓝不能逆转rTg4510小鼠tau蛋白病模型中已存在的神经原纤维缠结病理。

Spires-Jones, Tara L; Friedman, Taylor; Pitstick, Rose; Polydoro, Manuela; Roe, Allyson; Carlson, George A; Hyman, Bradley T