日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in dominant and recessive developmental and epileptic encephalopathies

对snRNA基因的系统分析揭示了显性和隐性发育性脑病和癫痫性脑病中常见的RNU2-2变异。

Leitão, Elsa; Santini, Amandine; Cogne, Benjamin; Essid, Miriam; Athanasiadou, Maria; LaFlamme, Christy W; Marijon, Pierre; Bernard, Virginie; Jousselin, Kevin; Chatron, Nicolas; Barcia, Giulia; Keren, Boris; Mignot, Cyril; Charles, Perrine; Besnard, Thomas; Paluch, Robin; de Sainte Agathe, Jean-Madeleine; Almanza Fuerte, Edith P; Sengupta, Soham; Milh, Mathieu; Ramond, Francis; Allan, Talia; An, Isabelle; Araujo, Camila; Arpin, Stéphanie; Austin-Tse, Christina; Auvin, Stéphane; Baer, Sarah; Bahi-Buisson, Nadia; Bak, Mads; Barth, Magalie; Baulac, Stéphanie; Bednarek-Weirauch, Nathalie; Begemann, Matthias; Bennett, Mark F; Bensabath, Uriel; Bézieau, Stéphane; Bhouri, Rakia; Biehler, Margaux; Hammer, Trine Bjørg; Bogoin, Julie; Bonanno, Emilie; Boussion, Simon; Bris, Céline; Brosseau-Beauvir, Adelaide; Bruel, Ange-Line; Briand-Suleau, Audrey; Buratti, Julien; Celse, Tristan; Chambon, Pascal; Chemaly, Nicole; Chesneau, Bertrand; Colin, Estelle; Colmard, Maxime; Colson, Cindy; Conrad, Solène; Courtin, Thomas; Creveaux, Isabelle; Cullier, Anne-Charlotte; Dang, Louis T; de Saint Martin, Anne; de Vanssay de Blavous Legendre, Caroline; Demeer, Bénédicte; Denommé-Pichon, Anne-Sophie; Diekhoff, Philine; DiTroia, Stephanie; Doco-Fenzy, Martine; Dubourg, Christèle; Dubucs, Charlotte; Ducreux, Stéphanie; Dufour, Louis; Duquet, Romain; Durand, Benjamin; El Chehadeh, Salima; Elbracht, Miriam; Faivre, Laurence; Faoucher, Marie; Faudet, Anne; Forlani, Sylvie; Fradin, Mélanie; Gaignard, Pauline; Ganne, Benjamin; Garde, Aurore; Géraud, Justine; Gill, Deepak; Goldenberg, Alice; Grabli, David; Grisel, Coraline; Gueden, Sophie; Gueguen, Paul; Guerrot, Anne-Marie; Guichet, Agnès; Haack, Tobias B; Härting, Nina; Häusler, Martin Georg; Heide, Solveig; Herget, Theresia; Héron, Bénédicte; Héron, Delphine; Herwig, Johanna; Heulin, Mathilde; Holling, Tess; Houdayer, Clara; Isidor, Bertrand; Jacquette, Aurélia; Januel, Louis; Jean-Marçais, Nolwenn; Kaiser, Frank J; Kaya, Sabine; King, Chontelle; Konyukh, Marina; Kraft, Florian; Krause, Jeremias; Kirstetter, Rémi; Kuechler, Alma; Kurth, Ingo; Kutsche, Kerstin; Labalme, Audrey; Laloy, Jean-Serene; Laugel, Vincent; Le Bricquir, Floriane; Lèbre, Anne-Sophie; Lebrun, Marine; Leguern, Eric; Levy, Jonathan; Lieffering, Nico; Lyonnet, Stanislas; Lüthy, Kevin; Macdonald, Sian M W; Mansour-Hendili, Lamisse; Maraval, Julien; Marquardt, Iris; Mattausch, Carolin; Mercier, Sandra; Messaoud, Olfa; Morel, Godelieve; Mortreux, Jérémie; Munnich, Arnold; Nabbout, Rima; Nambot, Sophie; Navarro, Vincent; Neale, Ashana; Nguyen, Laetitia; Nizon, Mathilde; Nowak, Frédérique; O'Leary, Melanie C; Odent, Sylvie; Ojeda, Naomi Meave; Olin, Valérie; Olivieri, Simone; Õunap, Katrin; Pais, Lynn S; Panagiotakaki, Eleni; Patat, Olivier; Perrin-Sabourin, Laurence; Petit, Florence; Philippe, Christophe; Piton, Amélie; Planes, Marc; Poirsier, Céline; Pouzet, Antoine; Prouteau, Clément; Quéméner-Redon, Sylvia; Renaud, Mathilde; Richard, Anne-Claire; Rio, Marlène; Rivier, Clotilde; Robin-Renaldo, Florence; Rollier, Paul; Rossi, Massimiliano; Roubertie, Agathe; Ruault, Valentin; Rupin-Mas, Maïlys; Saugier-Veber, Pascale; Saunier, Aline; Saneto, Russell; Sarrazin, Elisabeth; Sarret, Catherine; Schaefer, Elise; Schluth-Bolard, Caroline; Schneider, Amy; Schumann, Isabell; Seplyarskiy, Vladimir B; Spranger, Stephanie; Smol, Thomas; Sturm, Marc; Sunyaev, Shamil R; Sperelakis-Beedham, Brian; Stenton, Sarah L; Stock, Friedrich; Tharreau, Mylène; Torun, Deniz; Toulouse, Joseph; Thiyagarajah, Harshini; Valence, Stéphanie; Valleix, Sophie; Van-Gils, Julien; Villard, Laurent; Ville, Dorothée; Villeneuve, Nathalie; Vitobello, Antonio; Waernessyckle, Aurélie; Wagner, Jan; Weber, Yvonne; Wieczorek, Dagmar; Witkowski, Tom; Yadavilli, Manya; Yammine, Tony; Zaafrane-Khachnaoui, Khaoula; Zaki, Maha S; Ziegler, Alban; Bramswig, Nuria C; Lermine, Alban; Nicolas, Gael; Gleeson, Joseph G; Sadleir, Lynette G; Hildebrand, Michael S; Scheffer, Ingrid E; Whiffin, Nicola; O'Donnell-Luria, Anne; Mefford, Heather C; Blanc, Pierre; Thevenon, Julien; Charbonnier, Camille; Charenton, Clément; Depienne, Christel; Lesca, Gaetan; Nava, Caroline

Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models.

对全球小鼠甲基化组图谱的研究揭示了儿童癌症模型中亚型特异性拷贝数改变。

Schoof Melanie, Zheng Tuyu, Sill Martin, Imle Roland, Cais Alessia, Altendorf Lea, Fürst Alicia, Hofmann Nina, Ernst Kati, Vonficht Dominik, Chan Kenneth Chun-Ho, Holland-Letz Tim, Postlmayr Andreas, Shiraishi Ryo, Wang Wanchen, Morcavallo Alaide, Spohn Michael, Göbel Carolin, Niesen Judith, Peter Levke-Sophie, Bourdeaut Franck, Han Zhi-Yan, Pei Yanxin, Murad Najiba, Swartling Fredrik J, Taylor Jessica, Yadav Monika, Gibson Garrett R, Gilbertson Richard J, Dottermusch Matthias, Roy Rajanya, Kerl Kornelius, Glass Rainer, Cheng Jiying, Horstmann Martin A, Wolters-Eisfeld Gerrit, Zhao Haotian, Sturm Dominik, Yadav Viveka Nand, Chesler Louis, Haas Simon, Weiss William A, Northcott Paul A, Kutscher Lena M, Guerreiro Stucklin Ana, Ayrault Olivier, Neumann Julia E, Kawauchi Daisuke, Jones David T W, Pajtler Kristian, Banito Ana, Pfister Stefan M, Schüller Ulrich, Zuckermann Marc

CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency.

CAR 改造的 PIK3CD 碱基编辑增强了 T 细胞的抗肿瘤效力。

Bucher Philip, Brückner Nadine, Kortendieck Jule, Grimm Melanie, Schleicher Jan T, Bartels Karlotta, Hardy Steffen, Rausch Martina, Wurzer Hannah, Thiemann Meike, May Celina, Mitstorfer Mara, Letzgus Dennis, Quach Julia, Schneider Carolin, Ispan Denis A, Gonzalez-Menendez Irene, Jain Nayan, Ho Yu-Jui, Chen Jiangqing, Sánchez-Rivera Francisco J, Sun Jie, Quintanilla-Martinez Leticia, Trautwein Christoph, Weigelin Bettina, Claassen Manfred, Sadelain Michel, Feucht Judith, Leibold Josef

Evolution of the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones

结核菌素皮肤试验的演变揭示了可普遍存在的结核分枝杆菌反应性T细胞元克隆

Turner, Carolin T; Tiffeau-Mayer, Andreas; Rosenheim, Joshua; Chandran, Aneesh; Saxena, Rishika; Zhang, Ping; Jiang, Jana; Berkeley, Michelle; Pang, Flora; Uddin, Imran; Nageswaran, Gayathri; Byrne, Suzanne; Karthikeyan, Akshay; Smidt, Werner; Ogongo, Paul; Byng-Maddick, Rachel; Capocci, Santino; Lipman, Marc; Kunst, Heinke; Lozewicz, Stefan; Ramsuran, Veron; Pollara, Gabriele; Knight, Julian C; Leslie, Alasdair; Chain, Benjamin M; Noursadeghi, Mahdad

Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure.

心肌细胞中 IRF3 的激活通过抑制 PGC-1α 损害线粒体氧化功能,从而导致心力衰竭。

Kumari Manju, Evangelakos Ioannis, Deshpande Anushka, De Jong Kirstie A, Schmiedel Nesrin, Palacio-Escat Nicolàs, Chaves-Filho Adriano de Britto, Frias-Soler Roberto Carlos, Klinke Glynis, Roh Hyun Cheol, Lange Luisa, Berlin Michael, Fuh Marceline M, Buss Jakob Johannes, Tian Tian, Lerchenmüller Carolin, Freichel Marc, Schulze Almut, Nikolaev Viacheslav O, Eschenhagen Thomas, Rosen Evan D, Scheja Ludger, Rangrez Ashraf Yusuf, Heeren Joerg, Frey Norbert

Combined targeted and epigenetic-based therapy enhances antitumor immunity by stabilizing GATA6-dependent MHCI expression in pancreatic ductal adenocarcinoma.

靶向治疗与表观遗传治疗相结合,通过稳定胰腺导管腺癌中 GATA6 依赖的 MHCI 表达来增强抗肿瘤免疫力。

Peng JuanFei, Yang JiaJin, Antonopoulou Georgia, Fang Rui, Adhikari Bikash, Vogt Markus, Wolf Elmar, Sun Chong, Du Shangce, Godfrey Laura, Gupta Aayush, Trajkovic-Arsic Marija, Teichmann Nicole, Grünwald Barbara T, Krebs Niklas, Steiger Katja, Mogler Carolin, Althoff Kristina, Wang Xin, Giglio Giovanni, Liffers Sven-Thorsten, Savvatakis Konstantinos, Braren Rickmer, Lawlor Rita T, Scarpa Aldo, Behrens Diana, Lang Karl S, Cheung Phyllis F, Siveke Jens T

Correction to "Noncovalent Interactions in Density Functional Theory: All the Charge Density We Do Not See"

对“密度泛函理论中的非共价相互作用:我们看不到的所有电荷密度”一文的更正

Khabibrakhmanov, Almaz; Gori, Matteo; Müller, Carolin; Tkatchenko, Alexandre

Carriage of rare APOB variants predisposes to severe steatotic liver disease and hepatocellular carcinoma

携带罕见APOB变异基因会增加罹患严重脂肪肝和肝细胞癌的风险。

Mureddu, Matteo; Pelusi, Serena; Jamialahmadi, Oveis; Vujkovic, Marijana; Miano, Lorenzo; Eidgah Torghabehei, Hadi; Ronzoni, Luisa; Malvestiti, Francesco; Saracino, Marco; Periti, Giulia; Moretti, Vittoria; Teerlink, Craig C; Lynch, Julie A; Tsao, Philip S; Johnson, Josephine P; La Mura, Vincenzo; Dilena, Robertino; Alqahtani, Saleh A; Cherubini, Alessandro; Russo, Francesco Paolo; D'Ambrosio, Roberta; Fraquelli, Mirella; Petta, Salvatore; Miele, Luca; Vespasiani-Gentilucci, Umberto; Bugianesi, Elisabetta; Mancina, Rosellina M; Parini, Paolo; Prati, Daniele; Chang, Kyong-Mi; Schneider, Carolin V; Romeo, Stefano; Valenti, Luca Vc

Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt.

戊型肝炎病毒在肠隐窝内的增殖细胞中维持复制。

Prallet Sarah, Maier Niclas, Li Albert, Afting Cassian, Huang Hao-En, Hu Jungen, Toprak Elif, Keya Deb Purna, Colasanti Ombretta, León-Janampa Nancy, Marlet Julien, Beisel Claudia, Mogler Carolin, Puchas Philip, Behrendt Patrick, Boettler Tobias, Steinmann Eike, Saha Senjuti, Laketa Vibor, Lohmann Volker, Wittbrodt Joachim, Hermann Carl, Dill Michael T, Dao Thi Viet Loan

First-in-class SAM-competitive G9a inhibitor FLAV-27 as a disease-modifying therapy for Alzheimer disease.

首个SAM竞争性G9a抑制剂FLAV-27作为阿尔茨海默病疾病修饰疗法。

Bellver-Sanchis Aina, Valle-Garcia David, Barbaraci Carla, Romero-Becerra Fernando, Singh Rohit Kumar, Jarne-Ferrer Júlia, Vasilopoulou Foteini, Irisarri Alba, Martínez-Fernández Carmen, Fafián-Labora Juan A, Arufe María C, Wüst Carolin, Castellanos Aida, Soto David, Casals Núria, Fadó Rut, Pocock Jennifer M, Navarro Gemma, Val Cristina, Brea José, Loza M Isabel, Lleó Albert, Fortea Juan, Alcolea Daniel, Perez-Bosque Anna, Miró Lluïsa, Pérez Belén, Rashid Sajid, Ali Muhammad, Saqib Manahil, Lí Carbó Marcel, Guerrero Ana, Vázquez Santiago, Choudhary Bhanwar Singh, Dai Shaodong, Escolano Carmen, Franco Rafael, Pallàs Mercè, Griñán-Ferré Christian