日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lipid-Modulated, Graduated Inhibition of N-Glycosylation Pathway Priming Suggests Wide Tolerance of ER Proteostasis to Stress

脂质调控的N-糖基化途径启动的渐进性抑制表明内质网蛋白质稳态对压力具有广泛的耐受性

Giltrap, Andrew M; Morris, Niamh; Dong, Yin Yao; Cochrane, Stephen A; Krulle, Thomas; Hoekman, Steven; Semmelroth, Martin; Wollnik, Carina; Palmai-Pallag, Timea; Carpenter, Elisabeth P; Hollick, Jonathan; Parkes, Alastair; Rudhard, York; Davis, Benjamin G

Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease.

TASK-1 和 TASK-3 K2P 通道的结构揭示了它们在疾病中的门控和功能障碍

Hall Peter Rory, Jouen-Tachoire Thibault, Schewe Marcus, Proks Peter, Baukrowitz Thomas, Carpenter Elisabeth P, Newstead Simon, Rödström Karin E J, Tucker Stephen J

Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation

利用纳米抗体对TREK-2活性进行细胞外调控,有助于深入了解K2P通道调控机制。

Rödström, Karin E J; Cloake, Alexander; Sörmann, Janina; Baronina, Agnese; Smith, Kathryn H M; Pike, Ashley C W; Ang, Jackie; Proks, Peter; Schewe, Marcus; Holland-Kaye, Ingelise; Bushell, Simon R; Elliott, Jenna; Pardon, Els; Baukrowitz, Thomas; Owens, Raymond J; Newstead, Simon; Steyaert, Jan; Carpenter, Elisabeth P; Tucker, Stephen J

Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2

SIT1脯氨酸转运蛋白与COVID-19受体ACE2复合物的结构和功能

Li, Huanyu Z; Pike, Ashley C W; Lotsaris, Irina; Chi, Gamma; Hansen, Jesper S; Lee, Sarah C; Rödström, Karin E J; Bushell, Simon R; Speedman, David; Evans, Adam; Wang, Dong; He, Didi; Shrestha, Leela; Nasrallah, Chady; Burgess-Brown, Nicola A; Vandenberg, Robert J; Dafforn, Timothy R; Carpenter, Elisabeth P; Sauer, David B

Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea

KCNK3基因的功能获得性突变会导致一种伴有睡眠呼吸暂停的发育障碍

Sörmann, Janina; Schewe, Marcus; Proks, Peter; Jouen-Tachoire, Thibault; Rao, Shanlin; Riel, Elena B; Agre, Katherine E; Begtrup, Amber; Dean, John; Descartes, Maria; Fischer, Jan; Gardham, Alice; Lahner, Carrie; Mark, Paul R; Muppidi, Srikanth; Pichurin, Pavel N; Porrmann, Joseph; Schallner, Jens; Smith, Kirstin; Straub, Volker; Vasudevan, Pradeep; Willaert, Rebecca; Carpenter, Elisabeth P; Rödström, Karin E J; Hahn, Michael G; Müller, Thomas; Baukrowitz, Thomas; Hurles, Matthew E; Wright, Caroline F; Tucker, Stephen J

Site specificity determinants for prelamin A cleavage by the zinc metalloprotease ZMPSTE24

锌金属蛋白酶 ZMPSTE24 对前层粘连蛋白 A 的切割位点特异性决定因素

Babatz, Timothy D; Spear, Eric D; Xu, Wenxin; Sun, Olivia L; Nie, Laiyin; Carpenter, Elisabeth P; Michaelis, Susan

Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate

去甲氟西汀通过多种机制抑制TREK-2 K2P通道,包括对选择性过滤器门的独立于状态的影响。

Proks, Peter; Schewe, Marcus; Conrad, Linus J; Rao, Shanlin; Rathje, Kristin; Rödström, Karin E J; Carpenter, Elisabeth P; Baukrowitz, Thomas; Tucker, Stephen J

MON-648 Chronic Unpredictable Environmental Stress May Induce Predisposition to Diabetes Mellitus

MON-648 慢性不可预测的环境压力可能诱发糖尿病易感性

Shum, Michael; Shintre, Chitra A; Althoff, Thorsten; Gutierrez, Vincent; Segawa, Mayuko; Saxberg, Alexandra D; Martinez, Melissa; Adamson, Roslin; Young, Margaret R; Faust, Belinda; Gharakhanian, Raffi; Su, Shi; Chella Krishnan, Karthickeyan; Mahdaviani, Kiana; Veliova, Michaela; Wolf, Dane M; Ngo, Jennifer; Nocito, Laura; Stiles, Linsey; Abramson, Jeff; Lusis, Aldons J; Hevener, Andrea L; Zoghbi, Maria E; Carpenter, Elisabeth P; Liesa, Marc; Raghav, Alok

Structural and functional diversity calls for a new classification of ABC transporters

结构和功能的多样性要求对ABC转运蛋白进行新的分类。

Thomas, Christoph; Aller, Stephen G; Beis, Konstantinos; Carpenter, Elisabeth P; Chang, Geoffrey; Chen, Lei; Dassa, Elie; Dean, Michael; Duong Van Hoa, Franck; Ekiert, Damian; Ford, Robert; Gaudet, Rachelle; Gong, Xin; Holland, I Barry; Huang, Yihua; Kahne, Daniel K; Kato, Hiroaki; Koronakis, Vassilis; Koth, Christopher M; Lee, Youngsook; Lewinson, Oded; Lill, Roland; Martinoia, Enrico; Murakami, Satoshi; Pinkett, Heather W; Poolman, Bert; Rosenbaum, Daniel; Sarkadi, Balazs; Schmitt, Lutz; Schneider, Erwin; Shi, Yigong; Shyng, Show-Ling; Slotboom, Dirk J; Tajkhorshid, Emad; Tieleman, D Peter; Ueda, Kazumitsu; Váradi, András; Wen, Po-Chao; Yan, Nieng; Zhang, Peng; Zheng, Hongjin; Zimmer, Jochen; Tampé, Robert

A pharmacological master key mechanism that unlocks the selectivity filter gate in K(+) channels

一种能够解锁K(+)通道选择性过滤器闸门的药理学关键机制

Schewe, Marcus; Sun, Han; Mert, Ümit; Mackenzie, Alexandra; Pike, Ashley C W; Schulz, Friederike; Constantin, Cristina; Vowinkel, Kirsty S; Conrad, Linus J; Kiper, Aytug K; Gonzalez, Wendy; Musinszki, Marianne; Tegtmeier, Marie; Pryde, David C; Belabed, Hassane; Nazare, Marc; de Groot, Bert L; Decher, Niels; Fakler, Bernd; Carpenter, Elisabeth P; Tucker, Stephen J; Baukrowitz, Thomas