NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLL
NOTCH1信号通路因del(11q)缺失导致去泛素化酶USP28丢失而失调，提示USP28抑制剂可能是慢性淋巴细胞白血病(CLL)的一种新型治疗靶点。
期刊:Leukemia
影响因子:13.4
doi:10.1038/s41375-025-02632-4
Ehrmann, Alena Sophie; Quijada-Álamo, Miguel; Close, Viola; Guo, Min; Carracoi, Valentina; Pérez-Carretero, Claudia; Corchete, Luis Antonio; Friedrich, Tobias; Giaimo, Benedetto Daniele; Yosifov, Deyan Yordanov; Bloehdorn, Johannes; Rodríguez-Sánchez, Alberto; Tausch, Eugen; Schneider, Christof; Döhner, Hartmut; Kietzmann, Thomas; Borggrefe, Tilman; Stilgenbauer, Stephan; Oswald, Franz; Hernández-Rivas, Jesús-María; Mertens, Daniel
表观遗传
OTC
NOTCH
信号转导
泛素化
白血病
细胞生物学
USP28
