日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Atrophin-1 antisense oligonucleotide provides robust protection from pathology in a fully humanized DRPLA model.

Atrophin-1 反义寡核苷酸在完全人源化的 DRPLA 模型中提供了强大的病理保护作用。

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.1
doi:10.1016/j.omtn.2025.102815
Smith Velvet L, Gidi Bereket Z, Bragg Robert M, Cantle Jeffrey P, Ben-Varon Aliza, Noble Briana, Prades Silvia, Compton Andrea, Greenfield Julie, Korecka Joanna A, Gemos Anya, Yu Timothy, Khurana Vikram, Kordasiewicz Holly B, Zhao Hien T, Barker-Haliski Melissa, Child Daniel D, Carroll Jeffrey B
Human
ATR
发表日期：2026
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Huntingtin knockdown dysregulates autophagic degradation of Apolipoprotein E.

亨廷顿蛋白敲低会扰乱载脂蛋白 E 的自噬降解。

期刊:Journal of Huntingtons Disease
影响因子:3.1
doi:10.1177/18796397251391110
Fote Gianna M, McClure Nicolette R, Bragg Robert M, McKnight Jharrayne, Thompson Leslie M, Carroll Jeffrey B, Steffan Joan S
表观遗传
自噬
发表日期：2026
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Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.

通过转录抑制和直接 CAG 重复序列结合抑制亨廷顿病体细胞不稳定性。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-64936-4
Mathews Ella W, Coffey Sydney R, Gärtner Annette, Belgrad Jillian, Bragg Robert M, O'Reilly Daniel, Cantle Jeffrey P, McHugh Cassandra, Summers Ashley, Fentz Joachim, Schwagarus Tom, Cornelius Antje, Lingos Ioannis, Burch Zoe, Kovalenko Marina, Andrew Marissa A, Bennett C Frank, Kordasiewicz Holly B, Marchionini Deanna M, Wilkinson Hilary, Vogt Thomas F, Beuzer Paolo, Pinto Ricardo M, Khvorova Anastasia, Howland David, Wheeler Vanessa C, Carroll Jeffrey B
细胞生物学
发表日期：2025
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Altered huntingtin-chromatin interactions predict transcriptional and epigenetic changes in Huntington's disease.

亨廷顿蛋白-染色质相互作用的改变可预测亨廷顿病中的转录和表观遗传变化

期刊:Disease Models & Mechanisms
影响因子:3.3
doi:10.1242/dmm.052282
Pearl Jocelynn R, Shetty Amol C, Cantle Jeffrey P, Bergey Dani E, Bragg Robert M, Coffey Sydney R, Kordasiewicz Holly B, Hood Leroy E, Price Nathan D, Ament Seth A, Carroll Jeffrey B
表观遗传
发表日期：2025
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Establishing resources and increasing awareness to advance research on Dentatorubral-pallidoluysian atrophy toward a treatment: a patient organization perspective

从患者组织的角度出发，建立资源并提高公众意识，以推进齿状核红核苍白球路易体萎缩症的研究，最终找到治疗方法：

期刊:Therapeutic Advances in Rare Disease
影响因子:
doi:10.1177/26330040241249189
Prades, Silvia; Compton, Andrea; Carroll, Jeffrey B
发表日期：2024
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Understanding dentatorubral-pallidoluysian atrophy (DRPLA) symptoms and impacts on daily life: a qualitative interview study with patients and caregivers

了解齿状核红核苍白球路易体萎缩症（DRPLA）的症状及其对日常生活的影响：一项针对患者和护理人员的定性访谈研究

期刊:Therapeutic Advances in Rare Disease
影响因子:
doi:10.1177/26330040241252447
Contesse, Marielle G; Woods, Rebecca J; Leffler, Mindy; Prades, Silvia; Greenfield, Julie; Compton, Andrea; Carroll, Jeffrey B
发表日期：2024
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Stool is a sensitive and noninvasive source of DNA for monitoring expansion in repeat expansion disease mouse models

粪便是一种灵敏且无创的DNA来源，可用于监测重复序列扩增疾病小鼠模型中的扩增情况。

期刊:Disease Models & Mechanisms
影响因子:3.3
doi:10.1242/dmm.049453
Zhao, Xiaonan; McHugh, Cassandra; Coffey, Sydney R; Jimenez, Diego Antonio; Adams, Elizabeth; Carroll, Jeffrey B; Usdin, Karen
发表日期：2022
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Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations

单核RNA测序揭示亨廷顿病突变导致纹状体细胞身份失调

期刊:Journal of Neuroscience
影响因子:4
doi:10.1523/JNEUROSCI.2074-20.2021
Malaiya, Sonia; Cortes-Gutierrez, Marcia; Herb, Brian R; Coffey, Sydney R; Legg, Samuel R W; Cantle, Jeffrey P; Colantuoni, Carlo; Carroll, Jeffrey B; Ament, Seth A
细胞生物学
发表日期：2021
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Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints

降低朊病毒蛋白水平是一种能够改善朊病毒疾病各个阶段、毒株和终点的疾病治疗手段。

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaa616
Minikel, Eric Vallabh; Zhao, Hien T; Le, Jason; O'Moore, Jill; Pitstick, Rose; Graffam, Samantha; Carlson, George A; Kavanaugh, Michael P; Kriz, Jasna; Kim, Jae Beom; Ma, Jiyan; Wille, Holger; Aiken, Judd; McKenzie, Deborah; Doh-Ura, Katsumi; Beck, Matthew; O'Keefe, Rhonda; Stathopoulos, Jacquelyn; Caron, Tyler; Schreiber, Stuart L; Carroll, Jeffrey B; Kordasiewicz, Holly B; Cabin, Deborah E; Vallabh, Sonia M
微生物学
发表日期：2020
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Corrigendum: Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt(Q111/+) model of Huntington's disease

更正：在亨廷顿病B6.Htt(Q111/+)模型中，动机、蛋白质稳态和转录缺陷先于突触丢失、胶质增生和神经退行性变发生。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/srep44960
Bragg, Robert M; Coffey, Sydney R; Weston, Rory M; Ament, Seth A; Cantle, Jeffrey P; Minnig, Shawn; Funk, Cory C; Shuttleworth, Dominic D; Woods, Emily L; Sullivan, Bonnie R; Jones, Lindsey; Glickenhaus, Anne; Anderson, John S; Anderson, Michael D; Dunnett, Stephen B; Wheeler, Vanessa C; MacDonald, Marcy E; Brooks, Simon P; Price, Nathan D; Carroll, Jeffrey B
蛋白质稳态
神经科学
发表日期：2017
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