日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR-based functional genomics for dissecting therapeutic dependency in primary acute myeloid leukemia samples.

利用 CRISPR 技术进行功能基因组学分析,以揭示原发性急性髓系白血病样本的治疗依赖性。

Cao Zhendong, Yu Sixiang, Peng Jacqueline, Barrett Declan R, Liu Yuqiao, Sussman Jonathan H, Chen Changya, Thadi Anusha, Liu Li, Alikarami Fatemeh, Xu Jason, Carroll Martin P, Tan Kai, Bernt Kathrin M, Shi Junwei

CCAAT-enhancer binding protein delta functions as a tumor suppressor gene in acute myeloid leukemia

CCAAT增强子结合蛋白δ在急性髓系白血病中发挥抑癌基因的作用。

Prajapati, Subhash C; Meydan, Cem; Neelamraju, Yaseswini; Wang, Zhenjia; Atwood, Grant; Paudel, B Bishal; Fan, Hao; Dunham, Nicholas; Dillon, Richard; Gandara, Jorge A; Lee, Tak; Sheridan, Caroline; Wang, Shengyuan; Zumbo, Paul; Becker, Michael W; Bullinger, Lars; Carroll, Martin P; D'Andrea, Richard J; Levine, Ross L; Mason, Christopher E; Melnick, Ari M; Zang, Chongzhi; Bekiranov, Stefan; Garrett-Bakelman, Francine E

The LMO2-LDB1-TAL1 complex regulates transcription networks in acute myeloid leukemia

LMO2-LDB1-TAL1复合物调控急性髓系白血病中的转录网络

Dunham, Nicholas; Wang, Zhenjia; Neelamraju, Yaseswini; Guo, Yan; Paudel, B Bishal; Meydan, Cem; Gandara, Jorge A; Abdelmalak, Fady A; Fan, Hao; Hardwick, Joyce; Layer, Justin H; Lee, Tak; Maier, Bernhard; McDonald, W Hayes; Patnaik, Isaani; Prajapati, Subhash; Rapaport, Franck; Sheridan, Caroline; Sheynkman, Gloria; Zumbo, Paul; Becker, Michael W; Bullinger, Lars; Carroll, Martin P; D'Andrea, Richard J; Dillon, Richard; Levine, Ross L; Mason, Christopher E; Melnick, Ari M; Neuberg, Donna S; Bekiranov, Stefan; Zang, Chongzhi; Davé, Utpal P; Garrett-Bakelman, Francine E

Editor's Note: Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia

编者按:小分子抑制酰基赖氨酸阅读器ENL作为对抗急性髓系白血病的策略

Liu, Yiman; Li, Qinglan; Alikarami, Fatemeh; Barrett, Declan R; Mahdavi, Leila; Li, Hangpeng; Tang, Sylvia; Khan, Tanweer A; Michino, Mayako; Hill, Connor; Song, Lele; Yang, Lu; Li, Yuanyuan; Pokharel, Sheela Pangeni; Stamford, Andrew W; Liverton, Nigel; Renzetti, Louis M; Taylor, Simon; Watt, Gillian F; Ladduwahetty, Tammy; Kargman, Stacia; Meinke, Peter T; Foley, Michael A; Shi, Junwei; Li, Haitao; Carroll, Martin; Chen, Chun-Wei; Gardini, Alessandro; Maillard, Ivan; Huggins, David J; Bernt, Kathrin M; Wan, Liling

TP53 mutations and TET2 deficiency cooperate to drive leukemogenesis and establish an immunosuppressive environment

TP53突变和TET2缺陷协同作用,驱动白血病发生并建立免疫抑制环境。

Zhang, Pu; Whipp, Ethan C; Skuli, Sarah J; Gharghabi, Mehdi; Saygin, Caner; Sher, Steven A; Carroll, Martin; Pan, Xiangyu; Eisenmann, Eric D; Lai, Tzung-Huei; Harrington, Bonnie K; Chan, Wing Keung; Youssef, Youssef; Chen, Bingyi; Penson, Alex; Lewis, Alexander M; Castro, Cynthia R; Fox, Nina; Cihan, Ali; Le Luduec, Jean-Benoit; DeWolf, Susan; Kauffman, Tierney; Mims, Alice S; Canfield, Daniel; Phillips, Hannah; Williams, Katie E; Shaffer, Jami; Lozanski, Arletta; Doong, Tzyy-Jye; Lozanski, Gerard; Mao, Charlene; Walker, Christopher J; Blachly, James S; Daniyan, Anthony F; Alinari, Lapo; Baiocchi, Robert A; Yang, Yiping; Grieselhuber, Nicole R; Campbell, Moray J; Baker, Sharyn D; Blaser, Bradley W; Abdel-Wahab, Omar; Lapalombella, Rosa

DYRK1A inhibition results in MYC and ERK activation rendering KMT2A-R acute lymphoblastic leukemia cells sensitive to BCL2 inhibition

DYRK1A抑制导致MYC和ERK激活,使KMT2A-R急性淋巴细胞白血病细胞对BCL2抑制敏感。

Ayyadevara, V S S Abhinav; Wertheim, Gerald; Gaur, Shikha; Chukinas, John A; Loftus, Joseph P; Lee, Sung June; Kumar, Anil; Swaminathan, Srividya; Bhansali, Rahul S; Childers, Wayne; Geng, Huimin; Milne, Thomas A; Hua, Xianxin; Bernt, Kathrin M; Besson, Thierry; Shi, Junwei; Crispino, John D; Carroll, Martin; Tasian, Sarah K; Hurtz, Christian

Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response

TP53突变型急性髓系白血病的化疗耐药性需要甲羟戊酸的副产物——香叶基香叶基焦磷酸——来诱导适应性应激反应。

Skuli, Sarah J; Bakayoko, A'ishah; Kruidenier, Marisa; Manning, Bryan; Pammer, Paige; Salimov, Akmal; Riley, Owen; Brake-Sillá, Gisela; Dopkin, Derrick; Bowman, Michael; Martinez-Gutierrez, Leslie N; Anderson, Colin C; Reisz, Julie A; Buono, Roberta; Paul, Madhuri; Saland, Estelle; Liccardo, Francesca; DeVine, Ann; Wong, Sarah; Xu, Jimmy P; Nee, Eva; Hausler, Ryan; Boettcher, Steffen; Sebti, Said M; Lai, Catherine; Maxwell, Kara N; Sarry, Jean-Emmanuel; Fruman, David A; D'Alessandro, Angelo; Mesaros, Clementina; Keith, Brian; Simon, M Celeste; Sung, Pamela J; Wertheim, Gerald; Skuli, Nicolas; Bowman, Robert L; Matthews, Andrew; Carroll, Martin

Acquired BCL2 variants associated with venetoclax resistance in acute myeloid leukemia

获得性 BCL2 变异与急性髓系白血病中维奈托克耐药性相关

Brown, Fiona C; Wang, Xin; Birkinshaw, Richard; Chua, Chong Chyn; Morley, Thomas; Kasapgil, Sila; Pomilio, Giovanna; Blombery, Piers; Huang, David C S; Czabotar, Peter; Priore, Salvatore F; Yang, Guang; Carroll, Martin; Wei, Andrew H; Perl, Alexander E

Persistent postremission clonal hematopoiesis shapes the relapse trajectories of acute myeloid leukemia

持续性缓解后克隆性造血影响急性髓系白血病的复发轨迹

Chow, Ryan D; Velu, Priya; Deihimi, Safoora; Belman, Jonathan; Youn, Angela; Shah, Nisargbhai; Luger, Selina M; Carroll, Martin P; Morrissette, Jennifer; Bowman, Robert L

Tumor Lysis Syndrome in Acute Myeloid Leukemia Patients Treated With a Venetoclax Based Regimen

接受维奈托克方案治疗的急性髓系白血病患者发生肿瘤溶解综合征

Rowe, Margaret; Babushok, Daria; Carroll, Martin; Carulli, Alison; Frey, Noelle; Gill, Saar; Hexner, Elizabeth; Hirsh, Rebecca; Hossain, Nasheed; Lai, Catherine; Loren, Alison; Luger, Selina; Maillard, Ivan; McCurdy, Shannon; Matthews, Andrew; Martin, Mary Ellen; Paralkar, Vikram R; Perl, Alexander; Porter, David; Pratz, Keith; Stadtmauer, Edward; Bruno, Ximena Jordan