日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SGC-CAMKK2-1: A Chemical Probe for CAMKK2

SGC-CAMKK2-1:CAMKK2 的化学探针

Carrow Wells, Yi Liang, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O'Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael M Couñago, Brittany Stork, Christopher G Langendorf, Kevin Nay, Jonathan S Oakhi

Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series

RIOK2 化学探针:选择性 2-(酰氨基)吡啶系列的细胞效力改善

Christopher B Wang, Álvaro Lorente-Macías, Carrow Wells, Julie E Pickett, Alfredo Picado, William J Zuercher, Alison D Axtman

PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor

PKIS 深度研究为暗激酶和细胞活性 BRSK2 抑制剂提供了化学起点

Tigist Y Tamir, David H Drewry, Carrow Wells, M Ben Major, Alison D Axtman

A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways

一种新颖的筛选方法,通过比较三阴性乳腺癌中具有相似分子结构和不同生物学效应的小分子抑制剂的激酶活性来确定可靶向的信号通路

Margarite D Matossian, Hope E Burks, Steven Elliott, Van T Hoang, William J Zuercher, Carrow Wells, David H Drewry, Nirav Kapadia, Tiffany Chang, Thomas Yan, Gabrielle O Windsor, Khoa Nguyen, Fang Fang, Kenneth P Nephew, Aaron Buechlein, Douglas B Rusch, Rachel A Sabol, Deniz A Ucar, Jovanny Zabalet

New tools for carbohydrate sulfation analysis: heparan sulfate 2- O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

碳水化合物硫酸化分析的新工具:硫酸肝素2-O-磺基转移酶(HS2ST)是小分子蛋白激酶抑制剂的靶点

Dominic P Byrne, Yong Li, Krithika Ramakrishnan, Igor L Barsukov, Edwin A Yates, Claire E Eyers, Dulcé Papy-Garcia, Sandrine Chantepie, Vijayakanth Pagadala, Jian Liu, Carrow Wells, David H Drewry, William J Zuercher, Neil G Berry, David G Fernig, Patrick A Eyers

New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

评估蛋白酪氨酸硫酸化的新工具:酪氨酸蛋白磺基转移酶 (TPST) 是 RAF 蛋白激酶抑制剂的新靶点

Dominic P Byrne, Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E Eyers, Carrow Wells, David H Drewry, William J Zuercher, Neil G Berry, David G Fernig, Patrick A Eyers

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells

EGFR 家族蛋白激酶的共价抑制剂诱导癌细胞中人类 Tribbles 2 (TRIB2) 假激酶的降解

Daniel M Foulkes, Dominic P Byrne, Wayland Yeung, Safal Shrestha, Fiona P Bailey, Samantha Ferries, Claire E Eyers, Karen Keeshan, Carrow Wells, David H Drewry, William J Zuercher, Natarajan Kannan, Patrick A Eyers

Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes

已发表的激酶抑制剂组的新应用,用于识别三阴性乳腺癌亚型的治疗靶点和途径

Margarite D Matossian, Steven Elliott, Van T Hoang, Hope E Burks, Theresa B Phamduy, Douglas B Chrisey, William J Zuercher, David H Drewry, Carrow Wells, Bridgette Collins-Burow, Matthew E Burow