日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of mCMV280: An Oral Ectoparasiticide in the Isoxazoline Class with Reduced Mammalian Brain Exposure

mCMV280 的发现:一种异噁唑啉类口服体外寄生虫杀灭剂,可降低哺乳动物大脑暴露量

McComic, Sarah E; Wilson, Katy B; Li, Zhilin; Chen, Jeffrey; Weiss, Frank; Song, Lirui; Mazumdar, Wrickban; Dvorak, Curt A; Brittain, Jason; Lee, Kyoung-Jin; Li, Shuangwei; Joseph, Sean B; McNamara, Case W; Vos, Martijn W; Sheshachalam, Avinash; Inácio, Alex; Dechering, Koen J; Chatterjee, Arnab K; Swale, Daniel R

Inhibition of de novo fatty acid synthesis in Mycobacterium tuberculosis

抑制结核分枝杆菌从头脂肪酸合成

Roszkowski, Emma K; Charap, Sarita; Montague, Christine R; Sukheja, Paridhi; McNamara, Case W; Soma, Paul S; Islam, M Nurul; Graham, Barbara; Grzegorzewicz, Anna E; Jackson, Mary; Yang, Baiyuan; Hay, Anthony G; Russell, David G; Belisle, John T; VanderVen, Brian C

SuFEx-based antitubercular compound irreversibly inhibits Pks13

基于 SuFEx 的抗结核化合物不可逆地抑制 Pks13

Krieger, Inna V; Sukheja, Paridhi; Yang, Baiyuan; Tang, Su; Selle, Daniel; Woods, Ashley; Engelhart, Curtis; Kumar, Pradeep; Harbut, Michael B; Liu, Dongdong; Tsuda, Brendan; Qin, Bo; Bare, Grant A L; Li, Gencheng; Chi, Victor; Gambacurta, Julian; Hvizdos, Janine; Reagan, Matthew; Jones, Isabelle L; Massoudi, Lisa M; Woolhiser, Lisa K; Cascioferro, Alessandro; Kundrick, Erica; Singh, Parul; Reiley, William; Ioerger, Thomas R; Kandula, Dilipkumar Reddy; McCabe, Jacob W; Guo, Taijie; Alland, David; Boshoff, Helena I; Schnappinger, Dirk; Robertson, Gregory T; Mdluli, Khisi; Lee, Kyoung-Jin; Dong, Jiajia; Li, Shuangwei; Schultz, Peter G; Joseph, Sean B; Love, Melissa S; Sharpless, K Barry; Petrassi, H Michael; Chatterjee, Arnab K; Sacchettini, James C; McNamara, Case W

Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design

共价探针揭示结构化RNA中的小分子结合口袋,并实现生物活性化合物的设计

Kovachka, Sandra; Wang, Jielei; Taghavi, Amirhossein; Jia, Yilin; Asaba, Taro; Wolff, Karen C; Martin, Mason; Yang, Xueyi; Meyer, Samantha M; Ottilie, Sabine; Heacock, Mina; Cheng, Zhong; McNamara, Case W; Dubey, Gurudutt; Chatterjee, Arnab K; Chanda, Sumit; Gallego, José; Childs-Disney, Jessica L; Disney, Matthew D

A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites.

药物再利用方法揭示了间日疟原虫休眠子中可靶向的表观遗传通路

Maher Steven P, Bakowski Malina A, Vantaux Amélie, Flannery Erika L, Andolina Chiara, Gupta Mohit, Antonova-Koch Yevgeniya, Argomaniz Magdalena, Cabrera-Mora Monica, Campo Brice, Chao Alexander T, Chatterjee Arnab K, Cheng Wayne T, Chuenchob Vorada, Cooper Caitlin A, Cottier Karissa, Galinski Mary R, Harupa-Chung Anke, Ji Hana, Joseph Sean B, Lenz Todd, Lonardi Stefano, Matheson Jessica, Mikolajczak Sebastian A, Moeller Timothy, Orban Agnes, Padín-Irizarry Vivian, Pan Kastin, Péneau Julie, Prudhomme Jacques, Roesch Camille, Ruberto Anthony, Sabnis Saniya S, Saney Celia L, Sattabongkot Jetsumon, Sereshki Saleh, Suriyakan Sangrawee, Ubalee Ratawan, Wang Yinsheng, Wasisakun Praphan, Yin Jiekai, Popovici Jean, McNamara Case W, Joyner Chester, Nosten François H, Witkowski Benoît, Le Roch Karine G, Kyle Dennis E

Optimization of a micro-scale air-liquid-interface model of human proximal airway epithelium for moderate throughput drug screening for SARS-CoV-2

优化用于中等通量SARS-CoV-2药物筛选的人类近端气道上皮微尺度气液界面模型

Sen, Chandani; Rickabaugh, Tammy M; Jeyachandran, Arjit Vijey; Yuen, Constance; Ghannam, Maisam; Durra, Abdo; Aziz, Adam; Castillo, Kristen; Garcia, Gustavo Jr; Purkayastha, Arunima; Han, Brandon; Boulton, Felix W; Chekler, Eugene; Garces, Robert; Wolff, Karen C; Riva, Laura; Kirkpatrick, Melanie G; Gebara-Lamb, Amal; McNamara, Case W; Betz, Ulrich A K; Arumugaswami, Vaithilingaraja; Damoiseaux, Robert; Gomperts, Brigitte N

High-Throughput Repurposing Screen Reveals Compounds with Activity against Toxoplasma gondii Bradyzoites.

高通量药物重定位筛选揭示了对弓形虫缓殖子具有活性的化合物

Uddin Taher, Xia Jing, Fu Yong, McNamara Case W, Chatterjee Arnab K, Sibley L David

Open Source Repurposing Reveals Broad-Spectrum Antiviral Activity of Diphenylureas.

开源药物再利用揭示了二苯脲的广谱抗病毒活性

Betz Ulrich A K, Garces Robert, Beier Norbert, Lindemann Sven, Wolff Karen C, Riva Laura, Kirkpatrick Melanie G, Gebara-Lamb Amal, McNamara Case W, Damoiseaux Robert, Gomperts Brigitte N, Arumugaswami Vaithilingaraja, Strand MÃ¥rten, Gwon Yongdae, Elofsson Mikael, Evander Magnus

Synthesis and Structure-Activity Relationship of Covalent Inhibitors of SARS-CoV-2 Papain-Like Protease with Antiviral Potency

SARS-CoV-2木瓜蛋白酶样蛋白酶共价抑制剂的合成及构效关系及其抗病毒活性

Rouch, Catherine C; Chatterjee, Arnab K; McCarty, Connor; Song, Lirui; Chu, Alan; Johnson, Kristen; Heacock, Mina; Riva, Laura; McNamara, Case W; Wolff, Karen C; Greene-Cramer, Rebecca; Falco, Anna De; Montelione, Gaetano T; Grabovyi, Gennadii A

Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.

恶性疟原虫体外系统进化揭示了耐药性的关键决定因素

Luth Madeline R, Godinez-Macias Karla P, Chen Daisy, Okombo John, Thathy Vandana, Cheng Xiu, Daggupati Sindhu, Davies Heledd, Dhingra Satish K, Economy Jan M, Edgar Rebecca C S, Gomez-Lorenzo Maria G, Istvan Eva S, Jado Juan Carlos, LaMonte Gregory M, Melillo Bruno, Mok Sachel, Narwal Sunil K, Ndiaye Tolla, Ottilie Sabine, Palomo Diaz Sara, Park Heekuk, Peña Stella, Rocamora Frances, Sakata-Kato Tomoyo, Small-Saunders Jennifer L, Summers Robert L, Tumwebaze Patrick K, Vanaerschot Manu, Xia Guoqin, Yeo Tomas, You Ashley, Gamo Francisco-Javier, Goldberg Daniel E, Lee Marcus C S, McNamara Case W, Ndiaye Daouda, Rosenthal Philip J, Schreiber Stuart L, Serra Gloria, De Siqueira-Neto Jair Lage, Skinner-Adams Tina S, Uhlemann Anne-Catrin, Kato Nobutaka, Lukens Amanda K, Wirth Dyann F, Fidock David A, Winzeler Elizabeth A