日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

First-in-human phase 1 dose-escalation study of W0180, an anti-VISTA monoclonal antibody, with and without pembrolizumab in patients with locally advanced or metastatic solid tumours

首次人体1期剂量递增研究,评估抗VISTA单克隆抗体W0180联合或不联合帕博利珠单抗治疗局部晚期或转移性实体瘤患者的疗效。

Gomez-Roca, Carlos; Champiat, Stéphane; Danlos, Francois-Xavier; Castañón Álvarez, Eduardo; Cassier, Philippe Alexandre; Dupuy, Elena; Jegou, David; Primard, Marie; Pétain, Aurélie; Saccareau, Mathilde; Gueguen-Dorbes, Geneviève; Fabre, Claire; Marabelle, Aurélien; Melero, Ignacio

Identification of microenvironment features associated with primary resistance to anti-PD-1/PD-L1 + antiangiogenesis in gastric cancer through spatial transcriptomics and plasma proteomics.

通过空间转录组学和血浆蛋白质组学鉴定与胃癌中抗PD-1/PD-L1+抗血管生成原发性耐药相关的微环境特征

Cousin Sophie, Guégan Jean-Philippe, Shitara Kohei, Palmieri Lola Jade, Metges Jean Philippe, Pernot Simon, Fukuoka Shota, Koyama Shohei, Nishikawa Hiroyoshi, Bellera Carine A, Adenis Antoine, Gomez-Roca Carlos A, Cassier Philippe Alexandre, Hollebecque Antoine, Cantarel Coralie, Kind Michèle, Soubeyran Isabelle, Vanhersecke Lucile, Bessede Alban, Italiano Antoine

A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours

一项 1 期剂量递增研究,旨在评估 AsiDNA(一种首创的 DNA 修复抑制剂)在晚期实体瘤患者中静脉注射给药的安全性、药代动力学和药效学。

Le Tourneau, Christophe; Delord, Jean-Pierre; Kotecki, Nuria; Borcoman, Edith; Gomez-Roca, Carlos; Hescot, Ségolène; Jungels, Christiane; Vincent-Salomon, Anne; Cockenpot, Vincent; Eberst, Lauriane; Molé, Audrey; Jdey, Wael; Bono, Françoise; Trochon-Joseph, Véronique; Toussaint, Hélène; Zandanel, Christelle; Adamiec, Olga; de Beaumont, Olivier; Cassier, Philippe Alexandre

Part I of GANNET53: A European Multicenter Phase I/II Trial of the Hsp90 Inhibitor Ganetespib Combined With Weekly Paclitaxel in Women With High-Grade, Platinum-Resistant Epithelial Ovarian Cancer-A Study of the GANNET53 Consortium

GANNET53 第一部分:一项欧洲多中心 I/II 期临床试验,评估 Hsp90 抑制剂 Ganetespib 联合每周一次紫杉醇治疗高级别铂类耐药性上皮性卵巢癌女性患者的疗效——GANNET53 联盟研究

Ray-Coquard, Isabelle; Braicu, Ioana; Berger, Regina; Mahner, Sven; Sehouli, Jalid; Pujade-Lauraine, Eric; Cassier, Philippe Alexandre; Moll, Ute Martha; Ulmer, Hanno; Leunen, Karin; Zeimet, Alain Gustave; Marth, Christian; Vergote, Ignace; Concin, Nicole

A first-in-human study investigating biodistribution, safety and recommended dose of a new radiolabeled MAb targeting FZD10 in metastatic synovial sarcoma patients

一项首次人体研究,旨在调查一种靶向 FZD10 的新型放射性标记单克隆抗体在转移性滑膜肉瘤患者中的生物分布、安全性和推荐剂量。

Giraudet, Anne-Laure; Cassier, Philippe Alexandre; Iwao-Fukukawa, Chicaco; Garin, Gwenaelle; Badel, Jean-Noël; Kryza, David; Chabaud, Sylvie; Gilles-Afchain, Laurence; Clapisson, Gilles; Desuzinges, Claude; Sarrut, David; Halty, Adrien; Italiano, Antoine; Mori, Masaharu; Tsunoda, Takuya; Katagiri, Toyomasa; Nakamura, Yusuke; Alberti, Laurent; Cropet, Claire; Baconnier, Simon; Berge-Montamat, Sandrine; Pérol, David; Blay, Jean-Yves

A Retrospective Multicentric Study of Ewing Sarcoma Family of Tumors in Patients Older Than 50: Management and Outcome

一项针对50岁以上患者尤文氏肉瘤家族肿瘤的回顾性多中心研究:治疗和预后

Rochefort, Pauline; Italiano, Antoine; Laurence, Valérie; Penel, Nicolas; Lardy-Cleaud, Audrey; Mir, Olivier; Chevreau, Christine; Bertucci, Francois; Bompas, Emmanuelle; Chaigneau, Loic; Levy, Dominique; Ryckewaert, Thomas; Dumont, Sarah; Meeus, Pierre; Ranchere, Dominique; Blay, Jean-Yves; Cassier, Philippe Alexandre