日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

一项针对122341名欧洲血统患者的主要焦虑症的全基因组关联研究,发现了58个基因位点,并强调了GABA能信号传导的作用。

Strom, Nora I; Verhulst, Brad; Bacanu, Silviu-Alin; Cheesman, Rosa; Purves, Kirstin L; Gedik, Hüseyin; Mitchell, Brittany L; Kwong, Alex S; Faucon, Annika B; Singh, Kritika; Medland, Sarah; Colodro-Conde, Lucia; Krebs, Kristi; Hoffmann, Per; Herms, Stefan; Gehlen, Jan; Ripke, Stephan; Awasthi, Swapnil; Palviainen, Teemu; Tasanko, Elisa M; Peterson, Roseann E; Adkins, Daniel E; Shabalin, Andrey A; Adams, Mark J; Iveson, Matthew H; Campbell, Archie; Thomas, Laurent F; Winsvold, Bendik S; Drange, Ole Kristian; Børte, Sigrid; Ter Kuile, Abigail R; Naamanka, Joonas; Nguyen, Tan-Hoang; Meier, Sandra M; Corfield, Elizabeth C; Hannigan, Laurie; Levey, Daniel F; Czamara, Darina; Weber, Heike; Choi, Karmel W; Pistis, Giorgio; Couvy-Duchesne, Baptiste; Van der Auwera, Sandra; Teumer, Alexander; Karlsson, Robert; Garcia-Argibay, Miguel; Lee, Donghyung; Wang, Rujia; Bjerkeset, Ottar; Stordal, Eystein; Bäckman, Julia; Salum, Giovanni A; Zai, Clement C; Kennedy, James L; Zai, Gwyneth; Tiwari, Arun K; Heilmann-Heimbach, Stefanie; Schmidt, Börge; Kaprio, Jaakko; Kennedy, Martin M; Boden, Joseph; Havdahl, Alexandra; Middeldorp, Christel M; Lopes, Fabiana L; Akula, Nirmala; McMahon, Francis J; Binder, Elisabeth B; Fehm, Lydia; Ströhle, Andreas; Castelao, Enrique; Tiemeier, Henning; Stein, Dan J; Whiteman, David; Olsen, Catherine; Fuller, Zachary; Wang, Xin; Wray, Naomi R; Byrne, Enda M; Lewis, Glyn; Timpson, Nicholas J; Davis, Lea K; Hickie, Ian B; Gillespie, Nathan A; Milani, Lili; Schumacher, Johannes; Woldbye, David P; Forstner, Andreas J; Nöthen, Markus M; Hovatta, Iiris; Horwood, John; Copeland, William E; Maes, Hermine H; McIntosh, Andrew M; Andreassen, Ole A; Zwart, John-Anker; Mors, Ole; Børglum, Anders D; Mortensen, Preben B; Ask, Helga; Reichborn-Kjennerud, Ted; Najman, Jackob M; Stein, Murray B; Gelernter, Joel; Milaneschi, Yuri; Penninx, Brenda W; Boomsma, Dorret I; Maron, Eduard; Erhardt-Lehmann, Angelika; Rück, Christian; Kircher, Tilo T; Melzig, Christiane A; Alpers, Georg W; Arolt, Volker; Domschke, Katharina; Smoller, Jordan W; Preisig, Martin; Martin, Nicholas G; Lupton, Michelle K; Luik, Annemarie I; Reif, Andreas; Grabe, Hans J; Larsson, Henrik; Magnusson, Patrik K; Oldehinkel, Albertine J; Hartman, Catharina A; Breen, Gerome; Docherty, Anna R; Coon, Hilary; Conrad, Rupert; Lehto, Kelli; Deckert, Jürgen; Eley, Thalia C; Mattheisen, Manuel; Hettema, John M

Large-scale meta-analysis and precision functional assays identify FANCM regions in which PTVs confer different risks for ER-negative and triple-negative breast cancer

大规模荟萃分析和精准功能分析确定了FANCM区域中PTV赋予ER阴性和三阴性乳腺癌不同风险的基因表达谱。

Billaud, Amandine; Figlioli, Gisella; Mooser, Clémence; Casamassima, Irene; Azzoni, Violette; Srivatsa, Jahnavi; Colombo, Mara; Caleca, Laura; Ahearn, Thomas U; Andrulis, Irene L; Antoniou, Antonis C; Beckmann, Matthias W; Behrens, Sabine; Bermisheva, Marina; Bogdanova, Natalia V; Bolla, Manjeet K; Bonanni, Bernardo; Brüning, Thomas; Camp, Nicola J; Campbell, Archie; Castelao, Jose E; Cessna, Melissa H; Chang-Claude, Jenny; Czene, Kamila; Dennis, Joe; Devilee, Peter; Dörk, Thilo; Dunning, Alison M; Eriksson, Mikael; Evans, D Gareth; Fasching, Peter A; Figueroa, Jonine D; Gabrielson, Marike; Gago-Dominguez, Manuela; González-Neira, Anna; Guénel, Pascal; Hadjisavvas, Andreas; Hahnen, Eric; Hamann, Ute; Hillemanns, Peter; Hollestelle, Antoinette; Hooning, Maartje J; Hoppe, Reiner; Howell, Anthony; Jakubowska, Anna; Kristensen, Vessela N; Lubiński, Jan; Lush, Michael; Manoukian, Siranoush; Mavroudis, Dimitrios; Milne, Roger L; Mulligan, Anna Marie; Newman, William G; Obi, Nadia; Panayiotidis, Mihalis I; Pita, Guillermo; Rashid, Muhammad U; Rhenius, Valerie; Saloustros, Emmanouil; Sawyer, Elinor J; Schmutzler, Rita K; Shah, Mitul; Southey, Melissa C; Spurdle, Amanda B; Tomlinson, Ian; Truong, Thérèse; Wang, Qin; Wendt, Camilla; Auer, Paul L; Boddicker, Nicholas J; Bodelon, Clara; Burnside, Elizabeth S; Chen, Fei; Couch, Fergus J; Domchek, Susan M; Eliassen, Heather A; Haiman, Christopher; Hodge, James M; Hu, Chunling; Huang, Hongyan; Lindstrom, Sara; Martinez, Maria Elena; Nathanson, Katherine L; Neuhausen, Susan L; O'Brien, Katie M; Olson, Janet E; Palmer, Julie R; Patel, Alpa V; Ruddy, Kathryn J; Sandler, Dale P; Teras, Lauren R; Weinberg, Clarice R; Weitzel, Jeffrey N; Winham, Stacey J; Yadav, Siddhartha; Yao, Song; Zirpoli, Gary; Janatova, Marketa; Kleibl, Zdenek; Kleiblova, Petra; Soukupova, Jana; Zhao, Qihong; Devereux, Lisa; James, Paul A; Campbell, Ian G; Nguyen-Dumont, Tu; Dowty, James G; Andrieu, Nadine; Lesueur, Fabienne; Stoppa-Lyonnet, Dominique; Hoya, Miguel de la; Radice, Paolo; Sørensen, Claus Storgaard; Peterlongo, Paolo

Neuronal alkaline phosphatase promotes the spread of Tau-induced pathology, and its blockade prevents neurodegeneration and memory loss

神经元碱性磷酸酶促进Tau蛋白诱导的病理扩散,阻断该酶可预防神经退行性变和记忆丧失。

Soria-Tobar, Lucía; Ouro-Corredera, Daniel; Roman-Valero, Laura; Hernández, Félix; Millán, José Luis; Álvarez-Castelao, Beatriz; Sebastián-Serrano, Álvaro; Aivar, Paloma; Díaz-Hernández, Miguel

Systemic inflammatory profiles are associated with long-term kidney failure and patient mortality in chronic kidney disease

系统性炎症反应与慢性肾脏病患者的长期肾功能衰竭和死亡率相关。

Martínez-Castelao, Alberto; Hasegawa, Takehiro; Fernández-Fernández, Beatriz; Górriz, José Luis; Ortiz, Alberto; Quero, Maria; Fernández-Fresnedo, Gema; Zamora, Jorge-Iván; Soler, Maria Jose; Primo-Alvarez, José-Carlos; Robles, Nicolas Roberto; Venegas, Norma Inés; Ojeda, Felipe Ignacio; Gil-Paraíso, Antonio; Llorente-Cortijo, Irene Maria; Martínez-Villanueva, Caridad; Poch, Esteban; Sanchez-Rodriguez, Jinny; Li, Yun; Yuko, Saruta; Navarro-González, Juan F

Spanish primary students' writing attitudes and perceived family support: a socioemotional perspective

西班牙小学生写作态度及感知到的家庭支持:社会情感视角

Robledo, Patricia; Real Castelao, Sara; Rodríguez, Celestino; Álvarez-Fernández, María Lourdes

Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

对超过40万名女性的分析为BRCA1和BRCA2变异分类提供了病例对照证据。

Zanti, Maria; O'Mahony, Denise G; Parsons, Michael T; Dorling, Leila; Dennis, Joe; Boddicker, Nicholas J; Chen, Wenan; Hu, Chunling; Naven, Marc; Yiangou, Kristia; Ahearn, Thomas U; Ambrosone, Christine B; Andrulis, Irene L; Antoniou, Antonis C; Auer, Paul L; Baynes, Caroline; Bodelon, Clara; Bogdanova, Natalia V; Bojesen, Stig E; Bolla, Manjeet K; Brantley, Kristen D; Camp, Nicola J; Campbell, Archie; Castelao, Jose E; Cessna, Melissa H; Chang-Claude, Jenny; Chen, Fei; Chenevix-Trench, Georgia; Conroy, Don M; Czene, Kamila; De Nicolo, Arcangela; Domchek, Susan M; Dörk, Thilo; Dunning, Alison M; Eliassen, A Heather; Evans, D Gareth; Fasching, Peter A; Figueroa, Jonine D; Flyger, Henrik; Gago-Dominguez, Manuela; García-Closas, Montserrat; Glendon, Gord; González-Neira, Anna; Grassmann, Felix; Hadjisavvas, Andreas; Haiman, Christopher A; Hamann, Ute; Hart, Steven N; Hartman, Mikael B A; Ho, Weang-Kee; Hodge, James M; Hoppe, Reiner; Howell, Sacha J; Jakubowska, Anna; Khusnutdinova, Elza K; Ko, Yon-Dschun; Kraft, Peter; Kristensen, Vessela N; Lacey, James V; Li, Jingmei; Lim, Geok Hoon; Lindström, Sara; Lophatananon, Artitaya; Luccarini, Craig; Mannermaa, Arto; Martinez, Maria Elena; Mavroudis, Dimitrios; Milne, Roger L; Muir, Kenneth; Nathanson, Katherine L; Nuñez-Torres, Rocio; Obi, Nadia; Olson, Janet E; Palmer, Julie R; Panayiotidis, Mihalis I; Patel, Alpa V; Pharoah, Paul D P; Polley, Eric C; Rashid, Muhammad U; Ruddy, Kathryn J; Saloustros, Emmanouil; Sawyer, Elinor J; Schmidt, Marjanka K; Southey, Melissa C; Tan, Veronique Kiak-Mien; Teo, Soo Hwang; Teras, Lauren R; Torres, Diana; Trentham-Dietz, Amy; Truong, Thérèse; Vachon, Celine M; Wang, Qin; Weitzel, Jeffrey N; Yadav, Siddhartha; Yao, Song; Zirpoli, Gary R; Cline, Melissa S; Devilee, Peter; Tavtigian, Sean V; Goldgar, David E; Couch, Fergus J; Easton, Douglas F; Spurdle, Amanda B; Michailidou, Kyriaki

The role of multi-organ cancer predisposition genes in the risk of inherited and histologically diverse gastric cancer

多器官癌症易感基因在遗传性和组织学异质性胃癌风险中的作用

Joana Guerra ,Ana P Estrada-Florez ,Paul C Lott ,Carla Pinto ,Manuela Pinheiro ,Katherine A Chiu ,Dennis J Montoya ,Hongyong Zhang ,Guadalupe M Polanco-Echeverry ,Pedro Pinto ,Ana Peixoto ,Catarina Santos ,Ana Barbosa ,João Silva ,John Suarez-Olaya ,Fabian Castro-Valencia ,Graciela Molina ,Alejandro H Corvalán ,Adriana Della Valle ,Jose E Castelao ,Nereida Fernandez-Fernandez ,Lucia Cid ,Nora Rios-Sarabia ,Rafael Medrano ,Alejandra Mantilla ,Maria M Echeverry de Polanco ,Ana L Rivera-Herrera ,Julián Riaño-Moreno ,Rafael Parra-Medina ,Luz M González-Castrillón ,Ricardo Dominguez ,Ana R Isidoro ,Fernanda Silva ,Douglas R Morgan ,Alicia M Cock-Rada ,Maria C Sanabria-Salas ,Mabel H Bohorquez ,Javier Torres ,Manuel R Teixeira ,Luis G Carvajal-Carmona

Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer

从一项研究芳香化酶抑制剂治疗乳腺癌疗效的候选基因研究中汲取的经验教训

Hoppe, Reiner; Winter, Stefan; Lo, Wing-Yee; Michailidou, Kyriaki; Bolla, Manjeet K; Keeman, Renske; Wang, Qin; Dennis, Joe; Lush, Michael; Kalari, Krishna R; Goetz, Matthew P; Wang, Liewei; Cairns, Junmei; Weinshilboum, Richard; Shepherd, Lois; Chen, Bingshu E; Häberle, Lothar; Ruebner, Matthias; Beckmann, Matthias W; He, Wei; Larson, Nicole L; Armasu, Sebastian M; Schroth, Werner; Chowbay, Balram; Khor, Chiea Chuen; Abubakar, Mustapha; Antoniou, Antonis C; Brüning, Thomas; Castelao, Jose E; Chang-Claude, Jenny; Nbcs Collaborators; Dörk, Thilo; Eccles, Diana M; Figueroa, Jonine D; Gago-Dominguez, Manuela; García-Sáenz, José A; Gündert, Melanie; Hack, Carolin C; Hamann, Ute; Han, Sileny; Hooning, Maartje J; Huebner, Hanna; Abctb Investigators; John, Esther M; Ko, Yon-Dschun; Kristensen, Vessela N; Linn, Sabine; Margolin, Sara; Mavroudis, Dimitrios; Nevanlinna, Heli; Neven, Patrick; Obi, Nadia; Park-Simon, Tjoung-Won; Pylkäs, Katri; Rashid, Muhammad U; Romero, Atocha; Saloustros, Emmanouil; Sawyer, Elinor J; Tapper, William J; Tomlinson, Ian; Wendt, Camilla; Winqvist, Robert; Dunning, Alison M; Simard, Jacques; Hall, Per; Pharoah, Paul D P; Schwab, Matthias; Couch, Fergus J; Czene, Kamila; Fasching, Peter A; Easton, Douglas F; Schmidt, Marjanka K; Ingle, James N; Brauch, Hiltrud

Familial and genetic relationships of major depressive disorders and adiposity markers in the community

社区中重度抑郁症与肥胖标志物的家族和遗传关系

Berney, Alexandre; Pistis, Giorgio; Strippoli, Marie-Pierre F; Castelao, Enrique; Ranjbar, Setareh; Vollenweider, Peter; Vaucher, Julien; Marques-Vidal, Pedro; Kutalik, Zoltán; Lasserre, Aurélie; Clair, Carole; von Gunten, Armin; Merikangas, Kathleen R; Glaus, Jennifer; Vandeleur, Caroline L; Preisig, Martin

Interactions Between Genetic and Epidemiological Factors Influencing Mammographic Density

影响乳腺X线摄影密度的遗传因素和流行病学因素之间的相互作用

Suger, Austin Hammermeister; Chen, Hongjie; Haas, Cameron B; Fan, Shaoqi; Scott, Christopher G; Bolla, Manjeet K; Dennis, Joe; Dunning, Alison M; Michailidou, Kyriaki; Wang, Qin; Fasching, Peter A; Haeberle, Lothar; Stone, Jennifer; Gago-Dominguez, Manuela; Castelao, Jose E; Murphy, Rachel A; Aronson, Kristan; Couch, Fergus J; Yadav, Siddhartha; Milne, Roger L; Hopper, John L; Norman, Aaron; Eliassen, A Heather; Tapper, William J; Eccles, Diana M; Evans, D Gareth; Astley, Susan; Hall, Per; Czene, Kamila; Pharoah, Paul D P; Antoniou, Antonis C; García-Closas, Montserrat; Berrington, Amy; Easton, Douglas F; Gierach, Gretchen L; Tamimi, Rulla M; Vachon, Celine M; Lindström, Sara; Harrison, Tabitha A