日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Advances and challenges in plant N-glycoengineering: when fucosylation matters

植物N-糖基化工程的进展与挑战:岩藻糖基化何时发挥作用

Gauba, Kavya; Kunnummel, Vinny; Castilho, Alexandra

An engineered PD1-Fc fusion produced in N. benthamiana plants efficiently blocks PD1/PDL1 interaction

在烟草(N. benthamiana)植物中产生的工程化PD1-Fc融合蛋白能有效阻断PD1/PDL1相互作用。

Izadi, Shiva; Abrantes, Rafaela; Gumpelmair, Simon; Kunnummel, Vinny; Duarte, Henrique O; Steinberger, Peter; Reis, Celso A; Castilho, Alexandra

An ACE2-Fc decoy produced in glycoengineered plants neutralizes ancestral and newly emerging SARS-CoV-2 variants and demonstrates therapeutic efficacy in hamsters.

在糖基工程植物中产生的 ACE2-Fc 诱饵可以中和祖先和新出现的 SARS-CoV-2 变种,并在仓鼠身上证明了治疗效果

Föderl-Höbenreich Esther, Izadi Shiva, Hofacker Lara, Kienzl Nikolaus F, Castilho Alexandra, Strasser Richard, Tarrés-Freixas Ferran, Cantero Guillermo, Roca Núria, Pérez Mònica, Lorca-Oró Cristina, Usai Carla, Segalés Joaquim, Vergara-Alert Júlia, Mach Lukas, Zatloukal Kurt

Green and Hawksbill Sea turtles of Eastern Atlantic: New insights into a globally important rookery in the Gulf of Guinea

东大西洋的绿海龟和玳瑁海龟:对几内亚湾全球重要海龟繁殖地的新认识

Betânia Ferreira-Airaud, Sara Vieira, Maria Branco, Antunes Pina, Venceslau Soares, Manjula Tiwari, Matthew Witt, Rita Castilho, Alexandra Teodósio, Lucy A Hawkes

Reteplase Fc-fusions produced in N. benthamiana are able to dissolve blood clots ex vivo

本氏烟草中产生的瑞替普酶Fc融合蛋白能够在体外溶解血栓

Izadi, Shiva; Jalali Javaran, Mokhtar; Rashidi Monfared, Sajad; Castilho, Alexandra

BGAL1 depletion boosts the level of β-galactosylation of N- and O-glycans in N. benthamiana

BGAL1 缺失会提高本氏烟草中 N- 和 O-聚糖的 β-半乳糖基化水平

Kriechbaum, Ricarda; Ziaee, Esmaiel; Grünwald-Gruber, Clemens; Buscaill, Pierre; van der Hoorn, Renier A L; Castilho, Alexandra

In Planta Glycan Engineering and Functional Activities of IgE Antibodies.

植物体内聚糖工程和IgE抗体的功能活性

Montero-Morales Laura, Maresch Daniel, Crescioli Silvia, Castilho Alexandra, Ilieva Kristina M, Mele Silvia, Karagiannis Sophia N, Altmann Friedrich, Steinkellner Herta

An oligosaccharyltransferase from Leishmania major increases the N-glycan occupancy on recombinant glycoproteins produced in Nicotiana benthamiana

来自利什曼原虫的寡糖基转移酶可增加本氏烟草中产生的重组糖蛋白的N-糖基化程度。

Castilho, Alexandra; Beihammer, Gernot; Pfeiffer, Christina; Göritzer, Kathrin; Montero-Morales, Laura; Vavra, Ulrike; Maresch, Daniel; Grünwald-Gruber, Clemens; Altmann, Friedrich; Steinkellner, Herta; Strasser, Richard

Reduced paucimannosidic N-glycan formation by suppression of a specific β-hexosaminidase from Nicotiana benthamiana

通过抑制本氏烟草中一种特定的β-己糖胺酶,减少了寡甘露糖型N-聚糖的形成。

Shin, Yun-Ji; Castilho, Alexandra; Dicker, Martina; Sádio, Flavio; Vavra, Ulrike; Grünwald-Gruber, Clemens; Kwon, Tae-Ho; Altmann, Friedrich; Steinkellner, Herta; Strasser, Richard

The N-glycan on Asn54 affects the atypical N-glycan composition of plant-produced interleukin-22, but does not influence its activity

Asn54上的N-糖链影响植物源白细胞介素-22的非典型N-糖链组成,但不影响其活性。

Wilbers, Ruud H P; Westerhof, Lotte B; Reuter, Lauri J; Castilho, Alexandra; van Raaij, Debbie R; Nguyen, Dieu-Linh; Lozano-Torres, Jose L; Smant, Geert; Hokke, Cornelis H; Bakker, Jaap; Schots, Arjen