日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal-Like Epithelial State

老年小鼠体内适应不良的炎症信号通过促进持续的胎儿样上皮状态来损害结肠再生。

Korcari, Antonion; Tauc, Helen; Duggan, Jeff; Yun, Jina; Wehbe, Fabien; Darmanis, Spyros; Modrusan, Zora; Pappu, Rajita; Garfield, David; Jasper, Heinrich; Castillo-Azofeifa, David

Selective and Potent Peptide Binders of RNF43 for Wnt Signaling Inhibition.

选择性强、高效的RNF43肽结合剂,用于抑制Wnt信号通路。

Hwang Sunhee, Salcedo Paula Flórez, Korcari Antonion, Nicoludis John M, Valdivia Estefania Martinez, Peng Lingling, Balana Aaron T, Mak Justin, Crittenden Christopher M, Famili Amin, Liu Peter, Castillo-Azofeifa David, Hannoush Rami N, Miller Stephen E, Schroeder Christina I, Gao Xinxin

Engineered epithelial curvature controls Paneth cell localization in intestinal organoids.

工程化上皮曲率控制肠道类器官中潘氏细胞的定位。

Yavitt F Max, Khang Alex, Bera Kaustav, McNally Delaney L, Blatchley Michael R, Gallagher Aaron P, Klein Ophir D, Castillo-Azofeifa David, Dempsey Peter J, Anseth Kristi S

A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling

DLG1-ARHGAP31-CDC42轴对于肠道干细胞响应波动的微环境Wnt信号至关重要

David Castillo-Azofeifa ,Tomas Wald ,Efren A Reyes ,Aaron Gallagher ,Julia Schanin ,Stephanie Vlachos ,Nathalie Lamarche-Vane ,Carolyn Bomidi ,Sarah Blutt ,Mary K Estes ,Todd Nystul ,Ophir D Klein

Intracellular pH dynamics regulates intestinal stem cell lineage specification

细胞内pH动态变化调控肠道干细胞谱系分化。

Yi Liu ,Efren Reyes # ,David Castillo-Azofeifa # ,Ophir D Klein ,Todd Nystul ,Diane L Barber

Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis

上皮细胞TNF控制细胞分化和CFTR活性,以维持肠道黏蛋白稳态。

Efren A Reyes ,David Castillo-Azofeifa ,Jérémie Rispal ,Tomas Wald ,Rachel K Zwick ,Brisa Palikuqi ,Angela Mujukian ,Shervin Rabizadeh ,Alexander R Gupta ,James M Gardner ,Dario Boffelli ,Zev J Gartner ,Ophir D Klein

Cellular shape reinforces niche to stem cell signaling in the small intestine

细胞形状增强了小肠中干细胞信号传导的利基

Nalle Pentinmikko, Rodrigo Lozano, Sandra Scharaw, Simon Andersson, Johanna I Englund, David Castillo-Azofeifa, Aaron Gallagher, Martin Broberg, Ki-Young Song, Agustín Sola Carvajal, Alessondra T Speidel, Michael Sundstrom, Nancy Allbritton, Molly M Stevens, Ophir D Klein, Ana Teixeira, Pekka Kataji

Tools and Concepts for Interrogating and Defining Cellular Identity

用于探究和定义细胞身份的工具和概念

McKinley, Kara L; Castillo-Azofeifa, David; Klein, Ophir D

Lgr5+ telocytes are a signaling source at the intestinal villus tip

Lgr5+端粒细胞是肠绒毛顶端的信号来源

Keren Bahar Halpern ,Hassan Massalha ,Rachel K Zwick ,Andreas E Moor ,David Castillo-Azofeifa ,Milena Rozenberg ,Lydia Farack ,Adi Egozi ,Dan R Miller ,Inna Averbukh ,Yotam Harnik ,Noa Weinberg-Corem ,Frederic J de Sauvage ,Ido Amit ,Ophir D Klein ,Michal Shoshkes-Carmel ,Shalev Itzkovitz

A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage

大量活跃增殖的祖细胞协调外胚层附属物的自我更新和损伤修复。

Amnon Sharir ,Pauline Marangoni # ,Rapolas Zilionis # ,Mian Wan ,Tomas Wald ,Jimmy K Hu ,Kyogo Kawaguchi ,David Castillo-Azofeifa ,Leo Epstein ,Kyle Harrington ,Pierfrancesco Pagella ,Thimios Mitsiadis ,Christian W Siebel ,Allon M Klein ,Ophir D Klein