The PTP4A3 inhibitor KVX-053 reduces Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virulence, inflammation, and development of acute lung injury in K18-hACE2 mice
PTP4A3抑制剂KVX-053可降低K18-hACE2小鼠体内严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 的毒力、炎症反应和急性肺损伤的发生。
期刊:Respiratory Research
影响因子:5
doi:10.1186/s12931-025-03349-9
Colunga-Biancatelli, Ruben M L; Solopov, Pavel A; Woodson, Caitlin M; Allen, Irving Coy; Akhrymuk, Ivan; Akhrymuk, Maryna; Heath, Brittany N; Ivester, Hannah M; Day, Tierney; Austin, Dan E; Kehn-Hall, Kylene; Lazo, John S; Sharlow, Elizabeth R; Catravas, John D
SARS-CoV-2
炎症
炎症/感染
微生物学
ACE2
