日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Epigenome editing of human hematopoietic stem cells enables sustained and reversible thrombosis prevention

对人类造血干细胞进行表观基因组编辑可实现持续且可逆的血栓预防。

Ye, Tianyi; Xu, Wanying; Barrachina, Maria N; Lyu, Peng; Antoszewski, Mateusz; Volpe, Lucrezia Della; Guo, Chun-Jie; Lee, Andrew J; Theardy, Madelaine S; Shelton, Spencer D; Wahlster, Lara; Caulier, Alexis; Messa, Luana; Poeschla, Michael; Agarwal, Gaurav; Mitra, Ronodeep; Schmaier, Alec A; Weissman, Jonathan S; Machlus, Kellie R; Sankaran, Vijay G

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes

转录因子网络不成比例地富集了血细胞表型的遗传性

Martin-Rufino, Jorge Diego; Caulier, Alexis; Lee, Seayoung; Castano, Nicole; King, Emily; Joubran, Samantha; Jones, Marcus; Goldman, Seth R; Arora, Uma P; Wahlster, Lara; Lander, Eric S; Sankaran, Vijay G

Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS

CPX-351治疗高危急性髓系白血病(AML)患者的长期真实世界证据表明,该疗法可显著提高微小残留病灶(MRD)阴性率并延长总生存期(OS)。

Cluzeau, Thomas; Guolo, Fabio; Chiche, Edmond; Minetto, Paola; Rahme, Ramy; Bertoli, Sarah; Fianchi, Luana; Micol, Jean-Baptiste; Gottardi, Michele; Peterlin, Pierre; Galimberti, Sara; Thomas, Xavier; Rizzuto, Giuliana; Legrand, Olivier; Rondoni, Michela; Raffoux, Emmanuel; Bertani, Giambattista; Caulier, Alexis; D'Argenio, Michelina; Bonmati, Caroline; Billio, Atto; Lejeune, Caroline; Scappini, Barbara; Pigneux, Arnaud; Zappasodi, Patrizia; Recher, Christan; Grimaldi, Francesco; Ades, Lionel; Lemoli, Roberto M

NGS-based targeted sequencing guides risk-adapted and molecularly targeted therapy decisions in multiple myeloma

基于NGS的靶向测序指导多发性骨髓瘤的风险适应性和分子靶向治疗决策

Agarwal, Gaurav; Kazeroun, Mohammad; Salazar, Mirian; McBean, Khrystal; Kannan, Ananya; Larham, Jemma; Varghese, Sherin; Balik, Berrin; Browning, Joseph; Caulier, Alexis; Chan, Y L Tracey; Giles, Hannah; Jenner, Matthew; Kishore, Bhuvan; Pratt, Guy; Rabin, Neil; Robinson, Rebecca; Talbot, Alexis; van de Wyngaert, Zoé; Xu, Ke; Moore, Sally; Boyle, Eileen; Ansari-Pour, Naser; Ramasamy, Karthik; Hamblin, Angela; Thakurta, Anjan; Gooding, Sarah

Myeloid Neoplasms With Erythroid Predominance and Excess Blasts in Young Adults Exhibit Distinct Genetic Profiles

年轻成人中以红系细胞为主且原始细胞过多的髓系肿瘤表现出独特的遗传特征

Fenwarth, Laurène; Podvin, Benjamin; Vasseur, Loïc; Lebon, Delphine; Couillez, Guillaume; Berthon, Céline; Caulier, Alexis; Fournier, Elise; Bories, Claire; Carpentier, Benjamin; Tricot, Sabine; Wattebled, Kevin-James; Roche-Lestienne, Catherine; Lestringant, Valentin; Hauspie, Carine; Celli-Lebras, Karine; Heiblig, Maël; Dombret, Hervé; Itzykson, Raphael; Marolleau, Jean-Pierre; Garçon, Loïc; Preudhomme, Claude; Duployez, Nicolas; Boyer, Thomas

Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells.

基因变异揭示了一种同源异型长链非编码RNA,该RNA能够调节人类造血干细胞

Lyu Peng, Agarwal Gaurav, Guo Chun-Jie, Ye Tianyi, Weng Chen, Antoszewski Mateusz, Joubran Samantha, Caulier Alexis, Poeschla Michael, Sankaran Vijay G

PIEZO1 is essential for the survival and proliferation of acute myeloid leukemia cells

PIEZO1对于急性髓系白血病细胞的存活和增殖至关重要。

Lebon, Delphine; Collet, Louison; Djordjevic, Stefan; Gomila, Cathy; Ouled-Haddou, Hakim; Platon, Jessica; Demont, Yohann; Marolleau, Jean-Pierre; Caulier, Alexis; Garçon, Loïc

RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.

RNA聚合酶II的暂停在时间上协调细胞周期进程和红系分化

Martell Danya J, Merens Hope E, Caulier Alexis, Fiorini Claudia, Ulirsch Jacob C, Ietswaart Robert, Choquet Karine, Graziadei Giovanna, Brancaleoni Valentina, Cappellini Maria Domenica, Scott Caroline, Roberts Nigel, Proven Melanie, Roy Noémi B A, Babbs Christian, Higgs Douglas R, Sankaran Vijay G, Churchman L Stirling

Artificial intelligence to empower diagnosis of myelodysplastic syndromes by multiparametric flow cytometry

利用人工智能技术通过多参数流式细胞术辅助诊断骨髓增生异常综合征

Clichet, Valentin; Lebon, Delphine; Chapuis, Nicolas; Zhu, Jaja; Bardet, Valérie; Marolleau, Jean-Pierre; Garçon, Loïc; Caulier, Alexis; Boyer, Thomas

HDAC6 regulates human erythroid differentiation through modulation of JAK2 signalling

HDAC6通过调节JAK2信号通路调控人类红系细胞分化

Vong, Pascal; Messaoudi, Kahia; Jankovsky, Nicolas; Gomilla, Cathy; Demont, Yohann; Caulier, Alexis; Jedraszak, Guillaume; Demagny, Julien; Djordjevic, Stefan; Boyer, Thomas; Marolleau, Jean Pierre; Rochette, Jacques; Ouled-Haddou, Hakim; Garçon, Loïc