mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.
mTOR 依赖的核糖体基因转录调控需要 S6K1,并且是由核仁转录因子 UBF 的羧基末端激活结构域的磷酸化介导的
期刊:Molecular and Cellular Biology
影响因子:2.7
doi:10.1128/MCB.23.23.8862-8877.2003
Hannan Katherine M, Brandenburger Yves, Jenkins Anna, Sharkey Kerith, Cavanaugh Alice, Rothblum Lawrence, Moss Tom, Poortinga Gretchen, McArthur Grant A, Pearson Richard B, Hannan Ross D