TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasis.
TGF-β1介导的胰腺导管腺癌中L1CAM的下调驱动胶原蛋白17A1和MMP2的上调，从而促进肿瘤的侵袭性和转移
期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-025-07859-8
Cave Donatella Delle, Di Domenico Annalisa, Fantuz Marco, Ciotola Marianna, Mangini Maria, Buonaiuto Silvia, Corrado Brunella, Corona Marco, Saracino Federica, Andolfi Gennaro, Di Biase Ilaria, Cucciardi Antonio, Carrer Alessandro, Sainz Bruno Jr, Pirozzi Teresa, Re Daniele Lo, Colonna Vincenza, Minchiotti Gabriella, De Luca Anna Chiara, Lonardo Enza
