日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform

利用新型药物发现平台鉴定 PPM1D 小分子抑制剂

Wei Jiang, Subrata Shaw, Jason Rush, Nancy Dumont, John Kim, Ritu Singh, Adam Skepner, Carol Khodier, Cerise Raffier, Ni Yan, Cameron Schluter, Xiao Yu, Mateusz Szuchnicki, Murugappan Sathappa, Josephine Kahn, Adam S Sperling, David C McKinney, Alexandra E Gould, Colin W Garvie, Peter G Miller

Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state

通过改变构象状态对 PPM1D 丝氨酸/苏氨酸磷酸酶进行变构抑制

Peter G Miller #, Murugappan Sathappa #, Jamie A Moroco #, Wei Jiang, Yue Qian, Sumaiya Iqbal, Qi Guo, Andrew O Giacomelli, Subrata Shaw, Camille Vernier, Besnik Bajrami, Xiaoping Yang, Cerise Raffier, Adam S Sperling, Christopher J Gibson, Josephine Kahn, Cyrus Jin, Matthew Ranaghan, Alisha Caliman