日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small-molecule inhibition of the archetypal UbiB protein COQ8

小分子抑制原型UbiB蛋白COQ8

Nathan H Murray, Christopher R M Asquith, Zixiang Fang, Michael P East, Naomi Ptak, Robert W Smith, James D Vasta, Chad A Zimprich, Cesear R Corona, Matthew B Robers, Gary L Johnson, Craig A Bingman, David J Pagliarini

KRAS is vulnerable to reversible switch-II pocket engagement in cells

KRAS 在细胞中易受可逆的 switch-II 口袋接合的影响

James D Vasta #, D Matthew Peacock #, Qinheng Zheng #, Joel A Walker, Ziyang Zhang, Chad A Zimprich, Morgan R Thomas, Michael T Beck, Brock F Binkowski, Cesear R Corona, Matthew B Robers, Kevan M Shokat

Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

跨越正构和变构位点的“二合一”突变选择性表皮生长因子受体抑制剂的设计

Florian Wittlinger, David E Heppner, Ciric To, Marcel Günther, Bo Hee Shin, Jaimin K Rana, Anna M Schmoker, Tyler S Beyett, Lena M Berger, Benedict-Tilman Berger, Nicolas Bauer, James D Vasta, Cesear R Corona, Matthew B Robers, Stefan Knapp, Pasi A Jänne, Michael J Eck, Stefan A Laufer

A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins

用于生成杆状病毒 IAP 重复蛋白化学探针的工具箱

Martin P Schwalm, Lena M Berger, Maximilian N Meuter, James D Vasta, Cesear R Corona, Sandra Röhm, Benedict-Tilman Berger, Frederic Farges, Sebastian M Beinert, Franziska Preuss, Viktoria Morasch, Vladimir V Rogov, Sebastian Mathea, Krishna Saxena, Matthew B Robers, Susanne Müller, Stefan Knapp

Quantifying CDK inhibitor selectivity in live cells

量化活细胞中的 CDK 抑制剂选择性

Carrow I Wells #, James D Vasta #, Cesear R Corona, Jennifer Wilkinson, Chad A Zimprich, Morgan R Ingold, Julie E Pickett, David H Drewry, Kathryn M Pugh, Marie K Schwinn, Byounghoon Brian Hwang, Hicham Zegzouti, Kilian V M Huber, Mei Cong, Poncho L Meisenheimer, Timothy M Willson, Matthew B Robers

Discovery of a selective inhibitor of doublecortin like kinase 1

发现双皮质素样激酶 1 的选择性抑制剂

Fleur M Ferguson #, Behnam Nabet #, Srivatsan Raghavan, Yan Liu, Alan L Leggett, Miljan Kuljanin, Radha L Kalekar, Annan Yang, Shuning He, Jinhua Wang, Raymond W S Ng, Rita Sulahian, Lianbo Li, Emily J Poulin, Ling Huang, Jost Koren, Nora Dieguez-Martinez, Sergio Espinosa, Zhiyang Zeng, Cesear R Cor

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

活细胞中定量、广谱激酶分析用于评估细胞 ATP 对靶标参与的影响

James D Vasta, Cesear R Corona, Jennifer Wilkinson, Chad A Zimprich, James R Hartnett, Morgan R Ingold, Kristopher Zimmerman, Thomas Machleidt, Thomas A Kirkland, Kristin G Huwiler, Rachel Friedman Ohana, Michael Slater, Paul Otto, Mei Cong, Carrow I Wells, Benedict-Tilman Berger, Thomas Hanke, Cari

Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action

定量活细胞动力学降解和 PROTAC 作用方式的机制分析

Kristin M Riching, Sarah Mahan, Cesear R Corona, Mark McDougall, James D Vasta, Matthew B Robers, Marjeta Urh, Danette L Daniels

Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket

具有共价可逆结合模式的选择性JAK3抑制剂,靶向新的诱导契合结合口袋

Forster, Michael; Chaikuad, Apirat; Bauer, Silke M; Holstein, Julia; Robers, Matthew B; Corona, Cesear R; Gehringer, Matthias; Pfaffenrot, Ellen; Ghoreschi, Kamran; Knapp, Stefan; Laufer, Stefan A

Correction to Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis

对“具有新作用机制的有机金属铱(III)抗癌配合物:NCI-60筛选、线粒体靶向和细胞凋亡”一文的更正

George, Olivia; Bryant, Bj K; Chinnasamy, Ramesh; Corona, Cesear; Arterburn, Jeffrey B; Shuster, Charles B; Hearn, Jessica M; Romero-Canelon, Isolda; Qamar, Bushra; Liu, Zhe; Hands-Portman, Ian; Sadler, Peter J