日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small-molecule inhibition of the archetypal UbiB protein COQ8

小分子抑制原型UbiB蛋白COQ8

Nathan H Murray, Christopher R M Asquith, Zixiang Fang, Michael P East, Naomi Ptak, Robert W Smith, James D Vasta, Chad A Zimprich, Cesear R Corona, Matthew B Robers, Gary L Johnson, Craig A Bingman, David J Pagliarini

KRAS is vulnerable to reversible switch-II pocket engagement in cells

KRAS 在细胞中易受可逆的 switch-II 口袋接合的影响

James D Vasta #, D Matthew Peacock #, Qinheng Zheng #, Joel A Walker, Ziyang Zhang, Chad A Zimprich, Morgan R Thomas, Michael T Beck, Brock F Binkowski, Cesear R Corona, Matthew B Robers, Kevan M Shokat

Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites

跨越正构和变构位点的“二合一”突变选择性表皮生长因子受体抑制剂的设计

Florian Wittlinger, David E Heppner, Ciric To, Marcel Günther, Bo Hee Shin, Jaimin K Rana, Anna M Schmoker, Tyler S Beyett, Lena M Berger, Benedict-Tilman Berger, Nicolas Bauer, James D Vasta, Cesear R Corona, Matthew B Robers, Stefan Knapp, Pasi A Jänne, Michael J Eck, Stefan A Laufer

A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins

用于生成杆状病毒 IAP 重复蛋白化学探针的工具箱

Martin P Schwalm, Lena M Berger, Maximilian N Meuter, James D Vasta, Cesear R Corona, Sandra Röhm, Benedict-Tilman Berger, Frederic Farges, Sebastian M Beinert, Franziska Preuss, Viktoria Morasch, Vladimir V Rogov, Sebastian Mathea, Krishna Saxena, Matthew B Robers, Susanne Müller, Stefan Knapp

Quantifying CDK inhibitor selectivity in live cells

量化活细胞中的 CDK 抑制剂选择性

Carrow I Wells #, James D Vasta #, Cesear R Corona, Jennifer Wilkinson, Chad A Zimprich, Morgan R Ingold, Julie E Pickett, David H Drewry, Kathryn M Pugh, Marie K Schwinn, Byounghoon Brian Hwang, Hicham Zegzouti, Kilian V M Huber, Mei Cong, Poncho L Meisenheimer, Timothy M Willson, Matthew B Robers

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

活细胞中定量、广谱激酶分析用于评估细胞 ATP 对靶标参与的影响

James D Vasta, Cesear R Corona, Jennifer Wilkinson, Chad A Zimprich, James R Hartnett, Morgan R Ingold, Kristopher Zimmerman, Thomas Machleidt, Thomas A Kirkland, Kristin G Huwiler, Rachel Friedman Ohana, Michael Slater, Paul Otto, Mei Cong, Carrow I Wells, Benedict-Tilman Berger, Thomas Hanke, Cari

Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action

定量活细胞动力学降解和 PROTAC 作用方式的机制分析

Kristin M Riching, Sarah Mahan, Cesear R Corona, Mark McDougall, James D Vasta, Matthew B Robers, Marjeta Urh, Danette L Daniels