Targeting of phosphorylated tau at threonine 181 by a Qβ virus-like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaques.
通过 Qβ 病毒样颗粒疫苗靶向苏氨酸 181 处的磷酸化 tau 蛋白，是安全的，具有高度免疫原性，并能降低小鼠和恒河猴的疾病严重程度
期刊:Alzheimers & Dementia
影响因子:11.1
doi:10.1002/alz.70101
Maphis Nicole M, Hulse Jonathan, Peabody Julianne, Dadras Somayeh, Whelpley Madelin J, Kandath Manas, Wilson Colin, Hobson Sasha, Thompson Jeff, Poolsup Suttinee, Beckman Danielle, Ott Sean P, Watanabe Jennifer W, Usachenko Jodie L, Van Rompay Koen K, Morrison John, Selwyn Reed, Rosenberg Gary, Knoefel Janice, Chackerian Bryce, Bhaskar Kiran
