日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro.

p63 的 DBD 连接区中的选择性剪接可调节其在体外与 DNA 和 iASPP 的结合

Lotz Rebecca, Osterburg Christian, Chaikuad Apirat, Weber Sabrina, Akutsu Masato, Machel Anne Christin, Beyer Ulrike, Gebel Jakob, Löhr Frank, Knapp Stefan, Dobbelstein Matthias, Lu Xin, Dötsch Volker

Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design

TRIM家族PRYSPRY结构域的结构分析及其对E3配体设计的影响

Zhubi, Rezart; Chaikuad, Apirat; Muñoz Sosa, Christian J; Joerger, Andreas C; Knapp, Stefan

A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2

剧情出现转折:从JAK3中酪氨酸的共价靶向转变为MK2中赖氨酸的共价靶向。

Hillebrand, Laura; Wang, Guiqun; Rasch, Alexander; Masberg, Benedikt; Chaikuad, Apirat; Kronenberger, Thales; Günther, Ellen; Forster, Michael; Poso, Antti; Lämmerhofer, Michael; Laufer, Stefan A; Knapp, Stefan; Gehringer, Matthias

Synthesis and Characterization of ULK1/2 Kinase Inhibitors that Inhibit Autophagy and Upregulate Expression of Major Histocompatibility Complex I for the Treatment of Non-Small Cell Lung Cancer

合成和表征抑制自噬并上调主要组织相容性复合体I表达的ULK1/2激酶抑制剂,用于治疗非小细胞肺癌

Layng, Fabiana Izidro A L; Ren, Huiyu; Bakas, Nicole A; Panickar, Dhanya R; Lambert, Lester J; Celeridad, Maria; Wu, Jiaqian; De Backer, Laurent; Chandrachud, Preeti; Limpert, Allison S; Vamos, Mitchell; Chaikuad, Apirat; Verdugo, Betsaida B; Hagan, Patrick M; Brun, Sonja N; Tautz, Lutz; Knapp, Stefan; Shaw, Reuben J; Salvesen, Guy S; Sheffler, Douglas J; Cosford, Nicholas D P

DARPins as a novel tool to detect and degrade p73

DARPins 作为检测和降解 p73 的新工具

Philipp Münick #, Jasmin Zielinski #, Alexander Strubel #, Niklas Gutfreund, Birgit Dreier, Jonas V Schaefer, Birgit Schäfer, Jakob Gebel, Christian Osterburg, Apirat Chaikuad, Stefan Knapp, Andreas Plückthun, Volker Dötsch

Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation

靶向替代维生素E代谢物结合位点可实现非经典PPARγ调节

Arifi, Silvia; Marschner, Julian A; Pollinger, Julius; Isigkeit, Laura; Heitel, Pascal; Kaiser, Astrid; Obeser, Lennart; Höfner, Georg; Proschak, Ewgenij; Knapp, Stefan; Chaikuad, Apirat; Heering, Jan; Merk, Daniel

DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma

DARPins 检测上皮组织和鳞状细胞癌中 p63 和 p73 异四聚体的形成

Alexander Strubel #, Philipp Münick #, Oliver Hartmann, Apirat Chaikuad, Birgit Dreier, Jonas V Schaefer, Jakob Gebel, Christian Osterburg, Marcel Tuppi, Birgit Schäfer, Viktoria Buck, Mathias Rosenfeldt, Stefan Knapp, Andreas Plückthun, Markus E Diefenbacher, Volker Dötsch

Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ

基于结构的酪蛋白激酶 1ε 与酪蛋白激酶 1δ 异构体选择性抑制剂的开发

Jun Yong Choi, Yoshihiko Noguchi, James M Alburger, Simon Bayle, Eugene Chung, Wayne Grant, Apirat Chaikuad, Stefan Knapp, Derek R Duckett, William R Roush

Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis

tau 微管蛋白激酶 (TTBK1 和 TTBK2) 的调节影响纤毛发生

Frances M Bashore, Ariana B Marquez, Apirat Chaikuad, Stefanie Howell, Andrea S Dunn, Alvaro A Beltran, Jeffery L Smith, David H Drewry, Adriana S Beltran, Alison D Axtman

Structural insights into a regulatory mechanism of FIR RRM1-FUSE interaction

FIR RRM1-FUSE相互作用调控机制的结构解析

Ni, Xiaomin; Joerger, Andreas C; Chaikuad, Apirat; Knapp, Stefan