日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Effects of CT-388, a once-weekly signaling-biased dual GLP-1/GIP receptor agonist, on weight loss and glycemic control in preclinical models and participants with obesity

CT-388 是一种每周一次给药的信号传导偏向型双重 GLP-1/GIP 受体激动剂，本研究探讨了其对临床前模型和肥胖患者体重减轻和血糖控制的影响。

期刊:Molecular Metabolism
影响因子:6.6
doi:10.1016/j.molmet.2025.102291
Chakravarthy, Manu V; Rodriguez, Ruben; Hergarden, Anne; Elliott, Michael A; Frias, Juan P; Argüelles-Tello, Federico A; Tenorio, Edgar; Rankin, Jonathan E; Wu, Jingtao; Krishnan, Shyam; Erlanson, Daniel A; Fucini, Raymond V; Bone, Derek; Iwig, Jeffrey S; Acosta, Luis; Untereiner, Ashley; Pant, Asmita; Patton, Avalon; Sanchez-Sanchez, Leyla L; Luo, Jian; Steinberg, Alexandra; Bialonczyk, Damian; Hansen, Stig K
GLP-1
信号转导
代谢
GIP
肥胖
发表日期：2026
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An open-label study on ulotaront's effects on insulin-glucose regulation in schizophrenia patients with metabolic syndrome and prediabetes: Part I

一项关于乌洛他隆对伴有代谢综合征和糖尿病前期精神分裂症患者胰岛素-葡萄糖调节影响的开放标签研究：第一部分

期刊:Diabetes Obesity & Metabolism
影响因子:5.7
doi:10.1111/dom.70136
Milanovic, Snezana; Lew, Robert; Xiong, Kuangnan; Casavant, Emily; Galluppi, Gerard; Chen, Yu-Luan; Lai, Yongquan; Chakravarthy, Manu; Dehn, Clay; Koblan, Kenneth; Hopkins, Seth C
精神分裂症
神经科学
代谢
代谢综合征
糖尿病
免疫/内分泌
发表日期：2026
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A double-blind study on ulotaront's impact on weight-related parameters in schizophrenia patients with metabolic syndrome and prediabetes: Part II

一项关于乌洛他隆对伴有代谢综合征和糖尿病前期精神分裂症患者体重相关参数影响的双盲研究：第二部分

期刊:Diabetes Obesity & Metabolism
影响因子:5.7
doi:10.1111/dom.70110
Milanovic, Snezana; Lew, Robert; Xiong, Kuangnan; Casavant, Emily; Galluppi, Gerard; Chen, Yu-Luan; Lai, Yongquan; Chakravarthy, Manu; Dehn, Clay; Jackson, Edward; Koblan, Kenneth; Hopkins, Seth C
精神分裂症
神经科学
代谢
代谢综合征
糖尿病
发表日期：2026
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Efficacy and safety of CT-868, a novel, fully biased, dual glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptor agonist, in type 2 diabetes: A double-blind, randomized placebo controlled phase 2 trial

CT-868（一种新型的、完全偏向性的双重胰高血糖素样肽-1/葡萄糖依赖性促胰岛素多肽受体激动剂）治疗2型糖尿病的疗效和安全性：一项双盲、随机、安慰剂对照的II期试验

期刊:Diabetes Obesity & Metabolism
影响因子:5.7
doi:10.1111/dom.70006
Chakravarthy, Manu V; Elliott, Michael A; Acosta, Luis; Sonnenberg, Gabriele E; Bialonczyk, Damian; Wu, Jingtao; Argüelles-Tello, Federico A; Garcia-Reza, Raymundo; González-González, José Gerardo; Hansen, Stig K; Frias, Juan P
代谢
糖尿病
信号转导
免疫/内分泌
发表日期：2026
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Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy.

GLP-1R 和 GIPR 的偏向性激动作用可增强降血糖和减肥效果，而 GLP-1R/GIPR 的双重偏向性激动作用可产生更大的疗效

期刊:Cell Reports Medicine
影响因子:10.6
doi:10.1016/j.xcrm.2025.102156
Rodriguez Ruben, Hergarden Anne, Krishnan Shyam, Morales Marikris, Lam Davina, Tracy Ted, Tang Teresa, Patton Avalon, Lee Craig, Pant Asmita, Erlanson Daniel A, Enquist Johan, Bone Derek, Fucini Ray, Bialonczyk Damian, Hansen Stig K, Luo Jian, Chakravarthy Manu V
其它
发表日期：2025
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Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease

AXA1125 和 AXA1957 在非酒精性脂肪肝患者中的安全性、耐受性和生物活性

期刊:American Journal of Gastroenterology
影响因子:7.6
doi:10.14309/ajg.0000000000001375
Harrison, Stephen A; Baum, Seth J; Gunn, Nadege T; Younes, Ziad H; Kohli, Anita; Patil, Rashmee; Koziel, Margaret J; Chera, Harinder; Zhao, Jeff; Chakravarthy, Manu V
脂肪肝
代谢
发表日期：2021
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Correlations Between MRI Biomarkers PDFF and cT1 With Histopathological Features of Non-Alcoholic Steatohepatitis

MRI生物标志物PDFF和cT1与非酒精性脂肪性肝炎组织病理学特征的相关性

期刊:Frontiers in Endocrinology
影响因子:4.6
doi:10.3389/fendo.2020.575843
Dennis, Andrea; Kelly, Matt D; Fernandes, Carolina; Mouchti, Sofia; Fallowfield, Jonathan A; Hirschfield, Gideon; Pavlides, Michael; Harrison, Stephen; Chakravarthy, Manu V; Banerjee, Rajarshi; Sanyal, Arun
肝炎
发表日期：2020
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The metabolic basis of nonalcoholic steatohepatitis

非酒精性脂肪性肝炎的代谢基础

期刊:Endocrinology, Diabetes and Metabolism
影响因子:2.6
doi:10.1002/edm2.112
Chakravarthy, Manu V; Neuschwander-Tetri, Brent A
肝炎
代谢
发表日期：2020
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Decreased complexity of glucose dynamics preceding the onset of diabetes in mice and rats

小鼠和大鼠糖尿病发作前葡萄糖动力学复杂性降低

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0182810
Zhang, Xiaohua Douglas; Pechter, David; Yang, Liming; Ping, Xiaoli; Yao, Zuliang; Zhang, Rumin; Shen, Xiaolan; Li, Nina Xiaoyan; Connick, Jonathan; Nawrocki, Andrea R; Chakravarthy, Manu; Li, Cai
糖尿病
Rat
代谢
发表日期：2017
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Metabolic improvements following Roux-en-Y surgery assessed by solid meal test in subjects with short duration type 2 diabetes

对短期2型糖尿病患者进行固体餐试验，评估Roux-en-Y手术后的代谢改善情况

期刊:BMC Obesity
影响因子:
doi:10.1186/s40608-017-0149-1
Shankar, Sudha S; Mixson, Lori A; Chakravarthy, Manu; Chisholm, Robin; Acton, Anthony J; Jones, RoseMarie; Mattar, Samer G; Miller, Deborah L; Petry, Lea; Beals, Chan R; Stoch, S Aubrey; Kelley, David E; Considine, Robert V
糖尿病
代谢
发表日期：2017
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