日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Crystal structure of fatty acid thioesterase A bound by 129 fragments provides diverse development opportunities

脂肪酸硫酯酶A与129个片段结合的晶体结构提供了多种开发机会

Kot, Ekaterina; Ferla, Matteo Paolo; Hollinshead, Patricia Helen; Tomlinson, Charles William Ernest; Fearon, Daren; Aschenbrenner, Jasmin Cara; Koekemoer, Lizbé; Winokan, Max; Fairhead, Michael; Ni, Xiaomin; Chalk, Rod; England, Katherine Sara; Varga, Laura Ortega; Montgomery, Mark Greer; Mulholland, Nicholas Phillip; von Delft, Frank

"Design principles of a membrane-spanning ubiquitin ligase"

“跨膜泛素连接酶的设计原则”

Williams, Carys; Nocka, Laura M; Hedger, George; Parashara, Pragya; Pardon, Els; Latorraca, Naomi R; Pusapati, Ganesh V; Lartey, Dorothy; Gao, Lei; Milenkovic, Ljiljana; Chalk, Rod; Steyaert, Jan; Marqusee, Susan; Carrique, Loïc; Bazan, J Fernando; Rouse, Sarah L; Kong, Jennifer H; Siebold, Christian; Rohatgi, Rajat

Covalent Inhibitors of KEAP1 with Exquisite Selectivity.

具有极高选择性的KEAP1共价抑制剂

Fejes Imre, Markacz Piroska, Tatai Janos, Rudas Monika, Dunkel Petra, Gyuris Mario, Nyerges Miklos, Provost Nicolas, Duvivier Valérie, Delerive Philippe, Martiny Virginie, Bristiel Alexandra, Vidal Brice, Richardson William, Rothweiler Elisabeth M, Tranberg-Jensen Jeppe, Manning Charlotte E, Sweeney Melissa N, Chalk Rod, Huber Kilian V M, Bullock Alex N, Herner Andras, Seedorf Klaus, Vinson Cedric, Weber Csaba, Kotschy Andras

Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.

SHIP1 和 SHIP2 的 C2 结构域对肌醇 5-磷酸酶活性的调节

Bradshaw William J, Kennedy Emma C, Moreira Tiago, Smith Luke A, Chalk Rod, Katis Vittorio L, Benesch Justin L P, Brennan Paul E, Murphy Emma J, Gileadi Opher

Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease

SARS-CoV-2 NSP15 核糖核酸内切酶的变构调节和晶体学片段筛选

Godoy, Andre Schutzer; Nakamura, Aline Minalli; Douangamath, Alice; Song, Yun; Noske, Gabriela Dias; Gawriljuk, Victor Oliveira; Fernandes, Rafaela Sachetto; Pereira, Humberto D Muniz; Oliveira, Ketllyn Irene Zagato; Fearon, Daren; Dias, Alexandre; Krojer, Tobias; Fairhead, Michael; Powell, Alisa; Dunnet, Louise; Brandao-Neto, Jose; Skyner, Rachael; Chalk, Rod; Bajusz, Dávid; Bege, Miklós; Borbás, Anikó; Keserű, György Miklós; von Delft, Frank; Oliva, Glaucius

Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells

三环细胞穿透肽可高效地将功能性抗体递送至癌细胞内

Tietz, Ole; Cortezon-Tamarit, Fernando; Chalk, Rod; Able, Sarah; Vallis, Katherine A

Reducing hyperglucagonaemia in type 2 diabetes using low-dose glibenclamide: Results of the LEGEND-A pilot study

使用低剂量格列本脲降低 2 型糖尿病患者的高血糖素血症:LEGEND-A 试点研究的结果

Spiliotis, Ioannis I; Chalk, Rod; Gough, Stephen; Rorsman, Patrik

Identification, mapping and relative quantitation of SARS-CoV-2 Spike glycopeptides by Mass-Retention Time Fingerprinting

利用质谱保留时间指纹图谱法鉴定、定位和相对定量SARS-CoV-2刺突糖肽

Chalk, Rod; Greenland, William E P; Moreira, Tiago; Coker, Jesse; Mukhopadhyay, Shubhashish M M; Williams, Eleanor; Manning, Charlotte; Bohstedt, Tina; McCrorie, Rama; Fernandez-Cid, Alejandra; Burgess-Brown, Nicola A

An (111)In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells

一种(111)In标记的双钌(II)二吡啶并吩嗪诊疗复合物:错配DNA结合及对MMR缺陷型癌细胞的选择性放射毒性

Gill, Martin R; Walker, Michael G; Able, Sarah; Tietz, Ole; Lakshminarayanan, Abirami; Anderson, Rachel; Chalk, Rod; El-Sagheer, Afaf H; Brown, Tom; Thomas, Jim A; Vallis, Katherine A

Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases

Cullin3依赖性E3泛素连接酶KCTD家族的结构复杂性

Pinkas, Daniel M; Sanvitale, Caroline E; Bufton, Joshua C; Sorrell, Fiona J; Solcan, Nicolae; Chalk, Rod; Doutch, James; Bullock, Alex N