日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hepatic GCGR is required for the superior weight loss and metabolic effects of a structurally related analogue of the dual GCGR/GLP-1R agonist survodutide in mice

在小鼠体内,肝脏GCGR是双重GCGR/GLP-1R激动剂survodutide的结构相关类似物发挥更优减重和代谢作用所必需的。

Long, Fen; Challa, Tenagne D; Efthymiou, Vissarion; Klug, Manuel; Klein, Thomas; Neubauer, Heike; Wolfrum, Christian; Horvath, Carla

Adipocyte-specific deletion of gp130 prevents ketogenic diet-induced hepatic steatosis.

脂肪细胞特异性敲除 gp130 可预防生酮饮食引起的肝脂肪变性

Senkalfa Berkay, Gloor Melanie, Podlaszewski Ronja, Dewal Revati S, Horvath Carla, Efthymiou Vissarion, Ghosh Adhideb, Wueest Stephan, Konrad Daniel, Wolfrum Christian, Challa Tenagne D

Response-to Letter-to-the-editor: "A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice"

回应读者来信:“低碳水化合物饮食会诱发小鼠肝脏胰岛素抵抗和代谢相关脂肪肝疾病”

Wolfrum, Christian; Challa, Tenagne D

A low-carbohydrate diet induces hepatic insulin resistance and metabolic associated fatty liver disease in mice

低碳水化合物饮食可诱导小鼠肝脏胰岛素抵抗和代谢相关性脂肪肝疾病。

Long, Fen; Bhatti, Memoona R; Kellenberger, Alexandra; Sun, Wenfei; Modica, Salvatore; Höring, Marcus; Liebisch, Gerhard; Krieger, Jean-Philippe; Wolfrum, Christian; Challa, Tenagne D

Metabolic reconstitution of germ-free mice by a gnotobiotic microbiota varies over the circadian cycle

无菌小鼠通过无菌微生物群的代谢重建,其过程随昼夜节律而变化。

Hoces, Daniel; Lan, Jiayi; Sun, Wenfei; Geiser, Tobias; Stäubli, Melanie L; Cappio Barazzone, Elisa; Arnoldini, Markus; Challa, Tenagne D; Klug, Manuel; Kellenberger, Alexandra; Nowok, Sven; Faccin, Erica; Macpherson, Andrew J; Stecher, Bärbel; Sunagawa, Shinichi; Zenobi, Renato; Hardt, Wolf-Dietrich; Wolfrum, Christian; Slack, Emma

A short bout of HFD promotes long-lasting hepatic lipid accumulation

短期高脂饮食会促进肝脏长期脂质蓄积。

Chiazza, Fausto; Challa, Tenagne D; Lucchini, Fabrizio C; Konrad, Daniel; Wueest, Stephan