日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Trifunctional flavoenzyme-catalyzed asymmetric 4-alkyl-butenolide assembly in avenolide biosynthesis

三功能黄素酶催化的不对称4-烷基丁烯内酯组装在燕麦内酯生物合成中的作用

Li, Wenrui; Zhao, Jinlian; Zeng, Weibo; Zhang, Ruifei; Yan, Lei; Fan, Yuting; Liu, Jiaxin; Wang, Wenzhao; Challis, Gregory L; Zhou, Shanshan

PARAS: High-Accuracy Machine Learning of Substrate Specificities in Nonribosomal Peptide Synthetases

PARAS:非核糖体肽合成酶底物特异性的高精度机器学习

Terlouw, Barbara R; Huang, Chuan; Meijer, David; Cediel-Becerra, José D D; He, Ruolin; Rothe, Marlene L; Jenner, Matthew; Zhou, Shanshan; Zhang, Yu; Fage, Christopher D; Tsunematsu, Yuta; van Wezel, Gilles P; Robinson, Serina L; Alberti, Fabrizio; Alkhalaf, Lona M; Chevrette, Marc G; Challis, Gregory L; Medema, Marnix H

Biosynthesis of Biphenomycin-like Macrocyclic Peptides by Formation and Cross-Linking of Ortho-Tyrosines

通过邻位酪氨酸的形成和交联合成双苯霉素样大环肽

Padhi, Chandrashekhar; Zhu, Lingyang; Chen, Jeff Y; Huang, Chuan; Moreira, Ryan; Challis, Gregory L; Cryle, Max J; van der Donk, Wilfred A

Discovery of Late Intermediates in Methylenomycin Biosynthesis Active against Drug-Resistant Gram-Positive Bacterial Pathogens

发现亚甲基霉素生物合成后期中间体对耐药革兰氏阳性细菌病原体具有活性

Corre, Christophe; Idowu, Gideon A; Song, Lijiang; Whitehead, Melanie E; Alkhalaf, Lona M; Challis, Gregory L

Molecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in trans-Acyltransferase Polyketide Synthases

反式酰基转移酶聚酮合酶中酰基水解酶水解短链硫酯的分子基础

Fage, Christopher D; Passmore, Munro; Tatman, Ben P; Smith, Helen G; Jian, Xinyun; Dissanayake, Upeksha C; Foran, Mia E; Cisneros, G Andrés; Challis, Gregory L; Lewandowski, Józef R; Jenner, Matthew

Genome mining based on transcriptional regulatory networks uncovers a novel locus involved in desferrioxamine biosynthesis

基于转录调控网络的基因组挖掘揭示了参与去铁胺生物合成的新基因位点

Augustijn, Hannah E; Reitz, Zachary L; Zhang, Le; Boot, Jeanine A; Elsayed, Somayah S; Challis, Gregory L; Medema, Marnix H; van Wezel, Gilles P

Mode of Action and Mechanisms of Resistance to the Unusual Polyglycosylated Thiopeptide Antibiotic Persiathiacin A

不寻常的多糖基化硫肽类抗生素Persiathiacin A的作用方式和耐药机制

Woodgate, Jason; Sumang, Felaine A; Salliss, Mary E; Belousoff, Matthew; Ward, Alan C; Challis, Gregory L; Zenkin, Nikolay; Errington, Jeff; Dashti, Yousef

Teicoplanin Nonribosomal Peptide Synthetase Is Unable to Incorporate Alpha-Ketoacid Building Blocks

替考拉宁非核糖体肽合成酶无法掺入α-酮酸结构单元

Ratnayake, Minuri S; Jian, Xinyun; Tailhades, Julien; Challis, Gregory L; Hansen, Mathias H; Lewandowski, Józef R; Cryle, Max J

Antibiotic Skeletal Diversification via Differential Enoylreductase Recruitment and Module Iteration in trans-Acyltransferase Polyketide Synthases

通过差异性烯酰还原酶募集和转酰基转移酶聚酮合酶中的模块迭代实现抗生素骨架多样化

Jian, Xinyun; Pang, Fang; Hobson, Christian; Jenner, Matthew; Alkhalaf, Lona M; Challis, Gregory L

Gladiolin produced by pathogenic Burkholderia synergizes with amphotericin B through membrane lipid rearrangements.

致病性伯克霍尔德氏菌产生的唐菖蒲素通过膜脂重排与两性霉素B产生协同作用

Simm Claudia, Lee Tzong-Hsien, Weerasinghe Harshini, Walsh Dean, Nakou Ioanna T, Shankar Madhu, Tse Wai Chung, Zhang Yu, Inman Rebecca, Mulder Roger J, Harrison Freya, Aguilar Marie-Isabel, Challis Gregory L, Traven Ana