日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs

偏向性M1毒蕈碱受体突变小鼠为下一代药物的设计提供信息

Bradley, Sophie J; Molloy, Colin; Valuskova, Paulina; Dwomoh, Louis; Scarpa, Miriam; Rossi, Mario; Finlayson, Lisa; Svensson, Kjell A; Chernet, Eyassu; Barth, Vanessa N; Gherbi, Karolina; Sykes, David A; Wilson, Caroline A; Mistry, Rajendra; Sexton, Patrick M; Christopoulos, Arthur; Mogg, Adrian J; Rosethorne, Elizabeth M; Sakata, Shuzo; John Challiss, R A; Broad, Lisa M; Tobin, Andrew B

Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability

一氧化氮介导的翻译后修饰通过调节络合法呢基化并增强其夹紧能力来控制神经递质的释放

Susan W Robinson, Julie-Myrtille Bourgognon, Jereme G Spiers, Carlo Breda, Susanna Campesan, Adrian Butcher, Giovanna R Mallucci, David Dinsdale, Nobuhiro Morone, Raj Mistry, Tim M Smith, Maria Guerra-Martin, R A John Challiss, Flaviano Giorgini, Joern R Steinert

HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4

哮喘患者气道中的 HMGB1 上调,并通过 TLR4 增强气道平滑肌收缩

Leonarda Di Candia, Edith Gomez, Emilie Venereau, Latifa Chachi, Davinder Kaur, Marco E Bianchi, R A John Challiss, Christopher E Brightling, Ruth M Saunders

An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory

抗体生物传感器可确定学习和记忆过程中M1毒蕈碱乙酰胆碱受体的激活情况

Butcher, Adrian J; Bradley, Sophie J; Prihandoko, Rudi; Brooke, Simon M; Mogg, Adrian; Bourgognon, Julie-Myrtille; Macedo-Hatch, Timothy; Edwards, Jennifer M; Bottrill, Andrew R; Challiss, R A John; Broad, Lisa M; Felder, Christian C; Tobin, Andrew B

Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension

阐明血管收缩受体脱敏中阻遏蛋白2和阻遏蛋白3在高血压中的作用

Willets, Jonathon M; Nash, Craig A; Rainbow, Richard D; Nelson, Carl P; Challiss, R A John

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

环磷酸腺苷依赖性蛋白激酶和蛋白磷酸酶 2B 对大鼠动脉平滑肌电压门控 K+ 通道的稳态调节

Jennifer L Brignell, Matthew D Perry, Carl P Nelson, Jonathon M Willets, R A John Challiss, Noel W Davies

No evidence for altered intracellular calcium-handling in airway smooth muscle cells from human subjects with asthma

没有证据表明哮喘患者气道平滑肌细胞的细胞内钙处理发生改变

David Sweeney, Fay Hollins, Edith Gomez, Rajendra Mistry, Ruth Saunders, Robert Alfred John Challiss, Christopher Edward Brightling

[Ca2+]i oscillations in ASM: relationship with persistent airflow obstruction in asthma

气道平滑肌细胞内钙离子浓度 ([Ca2+]i) 振荡:与哮喘持续性气流阻塞的关系

Sweeney, David; Hollins, Fay; Gomez, Edith; Saunders, Ruth; Challiss, R A John; Brightling, Christopher E

Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels

需要长期通道阻滞来抑制人类 ether-à-go-go 相关基因 (hERG1) 钾通道的细胞转化

David M Pier, George S G Shehatou, Susan Giblett, Christine E Pullar, Derek J Trezise, Catrin A Pritchard, R A John Challiss, John S Mitcheson

Regulation of neuronal plasticity and fear by a dynamic change in PAR1-G protein coupling in the amygdala

杏仁核中PAR1-G蛋白偶联的动态变化调节神经元可塑性和恐惧

Bourgognon, J-M; Schiavon, E; Salah-Uddin, H; Skrzypiec, A E; Attwood, B K; Shah, R S; Patel, S G; Mucha, M; John Challiss, R A; Forsythe, I D; Pawlak, R