RUNX2 inhibition disrupts a PAX3::FOXO1-RUNX2 feed-forward loop and dismantles oncogenic gene programs in fusion-positive rhabdomyosarcoma.
RUNX2 抑制会破坏 PAX3::FOXO1-RUNX2 前馈环路,并瓦解融合阳性横纹肌肉瘤中的致癌基因程序
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doi:10.1101/2025.07.21.665972
Mendes Elizabeth A, Munshi Aanandi, Singh Archana, Evans Maisie D, Chou Hsien-Chao, Kim Yong Yean, Song Young, Jo Ara, Lee Daniel, Ciampi Jaida, Chambers Audrey, Weitzel Samantha, Deel Michael, Bentley Rex C, Khan Javed, Green Darrell, Linardic Corinne M