Chan Albert H相关文献与解析，生知库 | 链接生命科学的每一步

Dharmaiah, Srisathiyanarayanan; Bonsor, Daniel A; Mo, Stephanie P; Fernandez-Cabrera, Alvaro; Chan, Albert H; Messing, Simon; Drew, Matthew; Vega, Martha; Nissley, Dwight V; Esposito, Dominic; Castel, Pau; Simanshu, Dhirendra K

LZTR1

RAS

发表日期：2025

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Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.

发现 BBO-8520，一种首创的直接共价双重抑制剂，可抑制 GTP 结合 (ON) 和 GDP 结合 (OFF) 的 KRASG12C

期刊:Cancer Discovery

影响因子:33.3

doi:10.1158/2159-8290.CD-24-0840

Maciag Anna E, Stice James P, Wang Bin, Sharma Alok K, Chan Albert H, Lin Ken, Singh Devansh, Dyba Marcin, Yang Yue, Setoodeh Saman, Smith Brian P, Ju Jin Hyun, Jeknic Stevan, Rabara Dana, Zhang Zuhui, Larsen Erik K, Esposito Dominic, Denson John-Paul, Ranieri Michela, Meynardie Mary, Mehdizadeh Sadaf, Alexander Patrick A, Abreu Blanco Maria, Turner David M, Xu Rui, Lightstone Felice C, Wong Kwok-Kin, Stephen Andrew G, Wang Keshi, Simanshu Dhirendra K, Sinkevicius Kerstin W, Nissley Dwight V, Wallace Eli, McCormick Frank, Beltran Pedro J

其它

发表日期：2025

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Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

通过对 CaaX 盒半胱氨酸进行直接共价攻击，阻断 KRAS4b 的 C 端加工

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2410766122

Maciag Anna E, Yang Yue, Sharma Alok K, Turner David M, DeHart Caroline J, Abdelkarim Hazem, Fan Lixin, Smith Brian P, Kumari Vandana, Dyba Marcin, Rigby Megan, Castillo Badillo Jean A, Adams Lauren, Fornelli Luca, Fox Stephen, Brafman Alla, Turbyville Thomas, Gillette William, Messing Simon, Agamasu Constance, Wolfe Andrew L, Gysin Stephan, Chan Albert H, Simanshu Dhirendra K, Esposito Dominic, Chertov Oleg, Stephen Andrew G, Arkin Michelle, Renslo Adam, Kelleher Neil L, Gaponenko Vadim, Lightstone Felice C, Nissley Dwight V, McCormick Frank

其它

发表日期：2025

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Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints

对KRAS开关II口袋抑制剂的生物物理和结构分析揭示了等位基因特异性结合限制。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2025.110331

Alexander, Patrick; Chan, Albert H; Rabara, Dana; Swain, Monalisa; Larsen, Erik K; Dyba, Marcin; Chertov, Oleg; Ashraf, Mariam; Champagne, Allison; Lin, Ken; Maciag, Anna; Gillette, William K; Nissley, Dwight V; McCormick, Frank; Simanshu, Dhirendra K; Stephen, Andrew G

RAS

发表日期：2025

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Reduced dynamic complexity allows structure elucidation of an excited state of KRAS(G13D)

降低动态复杂性使得KRAS(G13D)激发态的结构解析成为可能

期刊:Communications Biology

影响因子:5.1

doi:10.1038/s42003-023-04960-6

Chao, Fa-An; Chan, Albert H; Dharmaiah, Srisathiyanarayanan; Schwieters, Charles D; Tran, Timothy H; Taylor, Troy; Ramakrishnan, Nitya; Esposito, Dominic; Nissley, Dwight V; McCormick, Frank; Simanshu, Dhirendra K; Cornilescu, Gabriel

Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase

新型计算机设计非核苷类抑制剂的结构研究及构效关系及其与HIV-1逆转录酶的相互作用

期刊:Frontiers in Molecular Biosciences

影响因子:4

doi:10.3389/fmolb.2022.805187

Frey, Kathleen M; Bertoletti, Nicole; Chan, Albert H; Ippolito, Joseph A; Bollini, Mariela; Spasov, Krasimir A; Jorgensen, William L; Anderson, Karen S

Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site

对与野生型和Y181C突变型逆转录酶结合的2-萘基苯醚抑制剂的结构研究突显了NNRTI结合位点的关键特征。

期刊:Protein Science

影响因子:5.2

doi:10.1002/pro.3910

Duong, Vincent N; Ippolito, Joseph A; Chan, Albert H; Lee, Won-Gil; Spasov, Krasimir A; Jorgensen, William L; Anderson, Karen S

发表日期：2020

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Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine

HIV-1逆转录酶识别核苷类逆转录酶抑制剂的结构解析：拉米夫定和恩曲他滨活性三磷酸形式的逆转录酶与逆转录酶的首个晶体结构

期刊:Protein Science

影响因子:5.2

doi:10.1002/pro.3681

Bertoletti, Nicole; Chan, Albert H; Schinazi, Raymond F; Yin, Y Whitney; Anderson, Karen S

NMR structure-based optimization of Staphylococcus aureus sortase A pyridazinone inhibitors.

基于核磁共振结构的金黄色葡萄球菌A型分选酶哒嗪酮抑制剂的优化

期刊:Chemical Biology & Drug Design

影响因子:3.3

doi:10.1111/cbdd.12962

Chan Albert H, Yi Sung Wook, Weiner Ethan M, Amer Brendan R, Sue Christopher K, Wereszczynski Jeff, Dillen Carly A, Senese Silvia, Torres Jorge Z, McCammon J Andrew, Miller Lloyd S, Jung Michael E, Clubb Robert T

微生物学

发表日期：2017

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The PRE-Derived NMR Model of the 38.8-kDa Tri-Domain IsdH Protein from Staphylococcus aureus Suggests That It Adaptively Recognizes Human Hemoglobin

来自金黄色葡萄球菌的38.8 kDa三结构域IsdH蛋白的PRE衍生NMR模型表明，它能够适应性地识别人类血红蛋白。

期刊:Journal of Molecular Biology

影响因子:4.5

doi:10.1016/j.jmb.2015.02.008

Sjodt, Megan; Macdonald, Ramsay; Spirig, Thomas; Chan, Albert H; Dickson, Claire F; Fabian, Marian; Olson, John S; Gell, David A; Clubb, Robert T

Human

发表日期：2016

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Structural basis for LZTR1 recognition of RAS GTPases for degradation

LZTR1识别RAS GTP酶并进行降解的结构基础

Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.

发现 BBO-8520，一种首创的直接共价双重抑制剂，可抑制 GTP 结合 (ON) 和 GDP 结合 (OFF) 的 KRASG12C

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

通过对 CaaX 盒半胱氨酸进行直接共价攻击，阻断 KRAS4b 的 C 端加工

Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints

对KRAS开关II口袋抑制剂的生物物理和结构分析揭示了等位基因特异性结合限制。

Reduced dynamic complexity allows structure elucidation of an excited state of KRAS(G13D)

降低动态复杂性使得KRAS(G13D)激发态的结构解析成为可能

Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase

新型计算机设计非核苷类抑制剂的结构研究及构效关系及其与HIV-1逆转录酶的相互作用

Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site

对与野生型和Y181C突变型逆转录酶结合的2-萘基苯醚抑制剂的结构研究突显了NNRTI结合位点的关键特征。

Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine

HIV-1逆转录酶识别核苷类逆转录酶抑制剂的结构解析：拉米夫定和恩曲他滨活性三磷酸形式的逆转录酶与逆转录酶的首个晶体结构

NMR structure-based optimization of Staphylococcus aureus sortase A pyridazinone inhibitors.

基于核磁共振结构的金黄色葡萄球菌A型分选酶哒嗪酮抑制剂的优化

The PRE-Derived NMR Model of the 38.8-kDa Tri-Domain IsdH Protein from Staphylococcus aureus Suggests That It Adaptively Recognizes Human Hemoglobin

来自金黄色葡萄球菌的38.8 kDa三结构域IsdH蛋白的PRE衍生NMR模型表明，它能够适应性地识别人类血红蛋白。