日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Advanced Paternal Age Impacts Common Loci in the Sperm and Placenta DNA Methylomes

父亲高龄会影响精子和胎盘DNA甲基化组中的常见位点

Barnwell, Julia; Rahimi, Sophia; Jones, Sherri Lee; Chan, Donovan; Martel, Josée; Abdessamie, Sara; Herba, Catherine M; Séguin, Jean R; Fraser, William D; Greenwood, Celia M T; Nguyen, Tuong-Vi; Montreuil, Tina C; Trasler, Jacquetta

Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation

5,10-亚甲基四氢叶酸还原酶677C>T变异小鼠模型中精子DNA甲基化缺陷及其通过中等剂量叶酸补充的纠正

Martínez Duncker Rebolledo, Edgar; Chan, Donovan; Christensen, Karen E; Reagan, Alaina M; Howell, Gareth R; Rozen, Rima; Trasler, Jacquetta

Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer

霍奇金淋巴瘤和睾丸癌患者在治疗前后均会出现精子DNA甲基化异常。

Chan, Donovan; Oros Klein, Kathleen; Riera-Escamilla, Antoni; Krausz, Csilla; O'Flaherty, Cristian; Chan, Peter; Robaire, Bernard; Trasler, Jacquetta M

Capturing sex-specific and hypofertility-linked effects of assisted reproductive technologies on the cord blood DNA methylome

捕捉辅助生殖技术对脐带血DNA甲基化组的性别特异性和低生育力相关影响

Rahimi, Sophia; Shao, Xiaojian; Chan, Donovan; Martel, Josée; Bérard, Anick; Fraser, William D; Simon, Marie-Michelle; Kwan, Tony; Bourque, Guillaume; Trasler, Jacquetta

Higher incidence of embryonic defects in mouse offspring conceived with assisted reproduction from fathers with sperm epimutations.

通过辅助生殖技术受孕的小鼠后代,其精子表观突变父亲所生的小鼠,胚胎缺陷发生率较高

Karahan Gurbet, Martel Josée, Rahimi Sophia, Farag Mena, Matias Fernando, MacFarlane Amanda J, Chan Donovan, Trasler Jacquetta

Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations

父系MTHFR缺陷会导致年轻逆转录转座子低甲基化,并导致连续两代生殖能力下降。

Karahan, Gurbet; Chan, Donovan; Shirane, Kenjiro; McClatchie, Taylor; Janssen, Sanne; Baltz, Jay M; Lorincz, Matthew; Trasler, Jacquetta

Early-Life Exposure to Environmental Contaminants Perturbs the Sperm Epigenome and Induces Negative Pregnancy Outcomes for Three Generations via the Paternal Lineage

早期接触环境污染物会扰乱精子表观基因组,并通过父系遗传导致三代不良妊娠结局。

Maurice, Clotilde; Dalvai, Mathieu; Lambrot, Romain; Deschênes, Astrid; Scott-Boyer, Marie-Pier; McGraw, Serge; Chan, Donovan; Côté, Nancy; Ziv-Gal, Ayelet; Flaws, Jodi A; Droit, Arnaud; Trasler, Jacquetta; Kimmins, Sarah; Bailey, Janice L

Single-cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID-19 patients

单细胞氧饱和度成像显示,新冠肺炎患者的红细胞气体交换功能并未受损。

Park, Kyung Chan; Donovan, Killian; McKechnie, Stuart; Ramamurthy, Narayan; Klenerman, Paul; Swietach, Pawel

Customized MethylC-Capture Sequencing to Evaluate Variation in the Human Sperm DNA Methylome Representative of Altered Folate Metabolism

定制化甲基C捕获测序用于评估代表叶酸代谢改变的人类精子DNA甲基化组的变异

Chan, Donovan; Shao, Xiaojian; Dumargne, Marie-Charlotte; Aarabi, Mahmoud; Simon, Marie-Michelle; Kwan, Tony; Bailey, Janice L; Robaire, Bernard; Kimmins, Sarah; San Gabriel, Maria C; Zini, Armand; Librach, Clifford; Moskovtsev, Sergey; Grundberg, Elin; Bourque, Guillaume; Pastinen, Tomi; Trasler, Jacquetta M

The DNMT1 intrinsically disordered domain regulates genomic methylation during development

DNMT1固有无序结构域在发育过程中调控基因组甲基化。

Shaffer, Ben; McGraw, Serge; Xiao, Siyu C; Chan, Donovan; Trasler, Jacquetta; Chaillet, J Richard